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The Product of the H19 Gene May Function as an RNA
Abstract
The mouse H19 gene was identified as an abundant hepatic fetal-specific mRNA under the transcriptional control of a trans-acting locus termed raf. The protein this gene encoded was not apparent from an analysis of its nucleotide sequence, since the mRNA contained multiple translation termination signals in all three reading frames. As a means of assessing which of the 35 small open reading frames might be important to the function of the gene, the human H19 gene was cloned and sequenced. Comparison of the two homologs revealed no conserved open reading frame. Cellular fractionation showed that H19 RNA is cytoplasmic but not associated with the translational machinery. Instead, it is located in a particle with a sedimentation coefficient of approximately 28S. Despite the fact that it is transcribed by RNA polymerase II and is spliced and polyadenylated, we suggest that the H19 RNA is not a classical mRNA. Instead, the product of this unusual gene may be an RNA molecule.
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Cites
Hann, S. R., King, M. W., Bentley, D. L., Anderson, C. W., & Eisenman, R. N. (1988) · Cell · doi:10.1016/0092-8674(88)90507-7 · Cited by 474
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Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals
Guttman, M., Amit, I., Garber, M., French, C., Lin, M. F., Feldser, D., Huarte, M., Zuk, O., Carey, B. W., Cassady, J. P., et al. (2009) · Nature · doi:10.1038/nature07672 · Cited by 4,098
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Kung, J. T. Y., Colognori, D., & Lee, J. T. (2013) · Genetics · doi:10.1534/genetics.112.146704 · Cited by 1,874
The functional role of long non-coding RNA in human carcinomas
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Metadata
- Authors
- Brannan, C. I., Dees, E. C., Ingram, R. S., & Tilghman, S. M.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1990-01
- Volume
- 10
- Issue
- 1
- Pages
- 28-36
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W4230224089
- Cited by
- 400
- References
- 1
- FWCI
- 0.54
- Type
- journal article
- Language
- en
- Open access
- closed
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- Brannan, C. I., Dees, E. C., Ingram, R. S., & Tilghman, S. M. (1990). The Product of the H19 Gene May Function as an RNA. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.10.1.28-36.1990
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
