Cited by 1,874Cancer-related molecular mechanisms researchChromosomal and Genetic VariationsRNA Research and Splicing

Long noncoding RNAs: past, present, and future

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Kung, Johnny T Y, Colognori, David, Lee, Jeannie T·2013·Genetics

Abstract

Long noncoding RNAs (lncRNAs) have gained widespread attention in recent years as a potentially new and crucial layer of biological regulation. lncRNAs of all kinds have been implicated in a range of developmental processes and diseases, but knowledge of the mechanisms by which they act is still surprisingly limited, and claims that almost the entirety of the mammalian genome is transcribed into functional noncoding transcripts remain controversial. At the same time, a small number of well-studied lncRNAs have given us important clues about the biology of these molecules, and a few key functional and mechanistic themes have begun to emerge, although the robustness of these models and classification schemes remains to be seen. Here, we review the current state of knowledge of the lncRNA field, discussing what is known about the genomic contexts, biological functions, and mechanisms of action of lncRNAs. We also reflect on how the recent interest in lncRNAs is deeply rooted in biology's longstanding concern with the evolution and function of genomes.

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  • Altered lncRNA transcriptional levels are associated with a variety of genetic disorders ranging from monogenic to complex disorders.

    “Numerous studies in the past several years showed that altered lncRNA transcriptional levels were associated with a variety of genetic disorders ranging from monogenic to complex disorders.[245]”

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Authors
Kung, J. T. Y., Colognori, D., & Lee, J. T.
Affiliations
Howard Hughes Medical Institute (US)
Corresponding author
Lee, Jeannie T
Venue
Genetics
Published
2013-03-01
Volume
193
Issue
3
Pages
651-669
ISSN
  • 0016-6731 (ISSN-L)
  • 1943-2631
OpenAlex
W2129375421
Cited by
1,874
References
269
Citations by year
2026: 36 · 2025: 63 · 2024: 102 · 2023: 121 · 2022: 188 · 2021: 251 · 2020: 220 · 2019: 208 · 2018: 205 · 2017: 165 · 2016: 127 · 2015: 95 · 2014: 64 · 2013: 27
FWCI
8.50
Type
journal article
Language
en
Open access
Locations
  • Genetics (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Howard Hughes Medical Institute
  • National Institute of General Medical Sciences (R01GM090278, R37GM058839, R01GM058839)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Keywords
long non-coding RNA, lncRNA classification, developmental regulation, disease regulation
MeSH terms
Animals, Humans, RNA Processing, Post-Transcriptional, Transcription, Genetic, Evolution, Molecular, Epigenesis, Genetic, RNA, Long Noncoding

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