The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The GLI gene encodes a nuclear protein which binds specific sequences in the human genome.
Open accessAbstract
The GLI gene is amplified in a subset of human tumors and encodes a protein product with five zinc finger DNA-binding motifs. In this study, we show that the GLI gene product has a predominantly nuclear localization and binds DNA in a sequence-specific fashion. Three GLI binding sites were identified by using a novel procedure in which total human DNA was bound to a GLI recombinant fusion protein, and the polymerase chain reaction was used to amplify and recover the bound sequences. The GLI protein protected a 23- to 24-base region within all three binding sites, and the protected region in each case included the 9-base-pair sequence 5'-GACCACCCA-3'. One of the binding sites was contained within a 63-base-pair repeat of the variable number of tandem repeat type, whereas the other two sites were represented once in the genome. The approach used here to identify GLI binding sites should be applicable to the characterization of other zinc finger proteins.
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Cites
Dystrophin: the protein product of the Duchenne muscular dystrophy locus
Hoffman, E. P., Brown, R. H., & Kunkel, L. M. (1987) · Cell · doi:10.1016/0092-8674(87)90579-4 · Cited by 4,693
Cited by
Definition of a consensus binding site for p53
El-Deiry, W. S., Kern, S. E., Pietenpol, J. A., Kinzler, K. W., & Vogelstein, B. (1992) · Nature Genetics · doi:10.1038/ng0492-45 · Cited by 1,985
Self-citationAmplification of a gene encoding a p53-associated protein in human sarcomas
Oliner, J. D., Kinzler, K. W., Meltzer, P. S., George, D. L., & Vogelstein, B. (1992) · Nature · doi:10.1038/358080a0 · Cited by 1,949
Self-citationHedgehog: functions and mechanisms
Varjosalo, M., & Taipale, J. (2008) · Genes & Development · doi:10.1101/gad.1693608 · Cited by 1,217
Crystal Structure of a Five-Finger GLI-DNA Complex: New Perspectives on Zinc Fingers
Pavletich, N. P., & Pabo, C. O. (1993) · Science · doi:10.1126/science.8378770 · Cited by 669
Sonic Hedgehog-induced Activation of the Gli1Promoter Is Mediated by GLI3
Dai, P., Akimaru, H., Tanaka, Y., Maekawa, T., Nakafuku, M., & Ishii, S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.12.8143 · Cited by 466
Metadata
- Authors
- Kinzler, K. W., & Vogelstein, B.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1990-02
- Volume
- 10
- Issue
- 2
- Pages
- 634-642
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W1785629757
- Cited by
- 475
- References
- 1
- FWCI
- 6.62
- Type
- journal article
- Language
- en
- Open access
- green
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- Kinzler, K. W., & Vogelstein, B. (1990). The GLI gene encodes a nuclear protein which binds specific sequences in the human genome. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.10.2.634
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