The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.
The amphiregulin gene encodes a novel epidermal growth factor-related protein with tumor-inhibitory activity.
Open accessAbstract
We have isolated the gene for a novel growth regulator, amphiregulin (AR), that is evolutionarily related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). AR is a bifunctional growth modulator: it interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells and inhibits the growth of certain aggressive carcinoma cell lines. The 84-amino-acid mature protein is embedded within a 252-amino-acid transmembrane precursor, an organization similar to that of the TGF-alpha precursor. Human placenta and ovaries were found to express significant amounts of the 1.4-kilobase AR transcript, implicating AR in the regulation of normal cell growth. In addition, the AR gene was localized to chromosomal region 4q13-4q21, a common breakpoint for acute lymphoblastic leukemia.
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Self-citationRutledge, B. J., Zhang, K., Bier, E., Jan, Y. N., & Perrimon, N. (1992) · Genes & Development · doi:10.1101/gad.6.8.1503 · Cited by 274
Role of resistant starch in improving gut health, adiposity, and insulin resistance
Keenan, M. J., Zhou, J., Hegsted, M., Pelkman, C., Durham, H. A., Coulon, D. B., & Martin, R. J. (2015) · Advances in Nutrition · doi:10.3945/an.114.007419 · Cited by 243
Metadata
- Authors
- Plowman, G. D., Green, J. M., McDonald, V. L., Neubauer, M. G., Disteche, C. M., Todaro, G. J., & Shoyab, M.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1990-05
- Volume
- 10
- Issue
- 5
- Pages
- 1969-1981
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W1924000143
- Cited by
- 377
- References
- 66
- FWCI
- 10.93
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: The amphiregulin gene encodes a novel epidermal growth factor-related protein with tumor-inhibitory activity. https://app.cochat.ai/papers/10.1128/mcb.10.5.1969
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- Plowman, G. D., Green, J. M., McDonald, V. L., Neubauer, M. G., Disteche, C. M., Todaro, G. J., & Shoyab, M. (1990). The amphiregulin gene encodes a novel epidermal growth factor-related protein with tumor-inhibitory activity. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.10.5.1969
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
