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Oxidant stress leads to transcriptional activation of the human heme oxygenase gene in cultured skin fibroblasts.
Open accessAbstract
Treatment of cultured human skin fibroblasts with near-UV radiation, hydrogen peroxide, and sodium arsenite induces accumulation of heme oxygenase mRNA and protein. In this study, these treatments led to a dramatic increase in the rate of RNA transcription from the heme oxygenase gene but had no effect on mRNA stability. Transcriptional activation, therefore, appears to be the major mechanism of stimulation of expression of this gene by either oxidative stress or sulfydryl reagents.
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Cited by
Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling
Ray, P. D., Huang, B.-W., & Tsuji, Y. (2012) · Cellular Signalling · doi:10.1016/j.cellsig.2012.01.008 · Cited by 4,373
Heme Oxygenase-1/Carbon Monoxide: From Basic Science to Therapeutic Applications
Ryter, S. W., Alam, J., & Choi, A. M. K. (2006) · Physiological Reviews · doi:10.1152/physrev.00011.2005 · Cited by 2,307
Choi, A. M., & Alam, J. (1996) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.15.1.8679227 · Cited by 1,126
REGULATION OF GENE EXPRESSION BY REACTIVE OXYGEN
Dalton, T. P., Shertzer, H. G., & Puga, A. (1999) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.39.1.67 · Cited by 1,118
Regulation of metallothionein gene expression by oxidative stress and metal ions
Andrews, G. K. (2000) · Biochemical Pharmacology · doi:10.1016/s0006-2952(99)00301-9 · Cited by 834
Metadata
- Authors
- Keyse, S. M., Applegate, L. A., Tromvoukis, Y., & Tyrrell, R. M.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1990-09
- Volume
- 10
- Issue
- 9
- Pages
- 4967-4969
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2130066440
- Cited by
- 226
- References
- 0
- FWCI
- 2.57
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Oxidant stress leads to transcriptional activation of the human heme oxygenase gene in cultured skin fibroblasts. https://app.cochat.ai/papers/10.1128/mcb.10.9.4967
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- Keyse, S. M., Applegate, L. A., Tromvoukis, Y., & Tyrrell, R. M. (1990). Oxidant stress leads to transcriptional activation of the human heme oxygenase gene in cultured skin fibroblasts. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.10.9.4967
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
