Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

Ray, Paul D.; Huang, Bo-Wen; Tsuji, Yoshiaki

doi:10.1016/j.cellsig.2012.01.008

Cited by 4,373Redox biology and oxidative stressAntioxidant Activity and Oxidative StressGenomics, phytochemicals, and oxidative stress

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

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Ray, Paul D., Huang, Bo-Wen, Tsuji, Yoshiaki·2012·Cellular Signalling

DOI 10.1016/j.cellsig.2012.01.008PMC PMC3454471

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Abstract

Reactive oxygen species (ROS) are generated during mitochondrial oxidative metabolism as well as in cellular response to xenobiotics, cytokines, and bacterial invasion. Oxidative stress refers to the imbalance due to excess ROS or oxidants over the capability of the cell to mount an effective antioxidant response. Oxidative stress results in macromolecular damage and is implicated in various disease states such as atherosclerosis, diabetes, cancer, neurodegeneration, and aging. Paradoxically, accumulating evidence indicates that ROS also serve as critical signaling molecules in cell proliferation and survival. While there is a large body of research demonstrating the general effect of oxidative stress on signaling pathways, less is known about the initial and direct regulation of signaling molecules by ROS, or what we term the "oxidative interface." Cellular ROS sensing and metabolism are tightly regulated by a variety of proteins involved in the redox (reduction/oxidation) mechanism. This review focuses on the molecular mechanisms through which ROS directly interact with critical signaling molecules to initiate signaling in a broad variety of cellular processes, such as proliferation and survival (MAP kinases, PI3 kinase, PTEN, and protein tyrosine phosphatases), ROS homeostasis and antioxidant gene regulation (thioredoxin, peroxiredoxin, Ref-1, and Nrf-2), mitochondrial oxidative stress, apoptosis, and aging (p66Shc), iron homeostasis through iron-sulfur cluster proteins (IRE-IRP), and ATM-regulated DNA damage response.

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ROS interacting with proteins impact several signaling pathways involved in the control of cell proliferation and apoptosis.
“By interacting with proteins, ROS have an impact on several signaling pathways involved in the control of cell proliferation and apoptosis.”
From ROS in cancer therapy: the bright side of the moon (2020) · cites this paper as [8]
ROS induces cell death, cell senescence, repair failure, inhibition of cell proliferation, and cell cycle arrest.
“Furthermore, ROS induces cell death11, cell senescence, repair failure12, inhibition of cell proliferation, and cell cycle arrest13.”
From Key points for the development of antioxidant cocktails to prevent cellular stress and damage caused by reactive oxygen species (ROS) during manned space missions (2021) · cites this paper as [11]
Citation 12 is attached to the claim about cell senescence and repair failure. Section 5 discusses ROS and aging, while section 7 discusses oxidative stress and DNA-repair signaling; neither states that ROS induces cellular senescence or repair failure. Searches for those terms found no passage establishing either outcome. (LLM, conf=0.72)
Experimental — accuracy not yet measured
In response to increased levels of ROS, PKC is activated, which in turn can activate NOXs.
“In response to the increased levels of ROS, the PKC is activated, which in turn, can activate NOXs (319, 776).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [776]
Redox dysregulation can affect cell proliferation and differentiation, energy metabolism, and neurotransmission through altered redox-sensitive protein function, redox-dependent gene expression, and epigenetic mechanisms.
“A redox dysregulation can affect cell proliferation/differentiation, energy metabolism, and neurotransmission via an alteration of redox-sensitive protein function, redox-dependent gene expression, and epigenetic mechanisms (Cyr and Domann, 2011; Ray et al., 2012; Valko et al., 2007).”
From Redox dysregulation, neuroinflammation, and NMDA receptor hypofunction: A “central hub” in schizophrenia pathophysiology? (2016) · cites this paper as Ray et al., 2012

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[86]Hsieh TC Lu X Wang Z Wu JM Med Chem 2 2006 275 285 16948474
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“Concurrently, it is well appreciated that ROS are at the interface of several cell signaling pathways that regulate cell proliferation, differentiation, and death (D’Autréaux and Toledano, 2007; Finkel, 2011; Ray et al., 2012).”
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Authors: Ray, P. D., Huang, B.-W., & Tsuji, Y.
Affiliations: North Carolina State University (US)
Corresponding author: Tsuji, Yoshiaki
ORCID: Tsuji, Yoshiaki
Venue: Cellular Signalling
Publisher: Elsevier BV
Published: 2012-05
Volume: 24
Issue: 5
Pages: 981-990
ISSN: 0898-6568 (ISSN-L)
DOI: 10.1016/j.cellsig.2012.01.008
PMC: PMC3454471
OpenAlex: W2084299658
Cited by: 4,373
References: 145
Citations by year: 2026: 163 · 2025: 269 · 2024: 358 · 2023: 372 · 2022: 428 · 2021: 440 · 2020: 411 · 2019: 375 · 2018: 322 · 2017: 296 · 2016: 257 · 2015: 245 · 2014: 199 · 2013: 171 · 2012: 62
FWCI: 19.78
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cellular Signalling (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of General Medical Sciences (R01 GM-088392, R01 GM-095550)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
Keywords: reactive oxygen species, redox signaling, oxidative stress, ROS homeostasis, antioxidant response, MAPK signaling, PI3-kinase, PTEN, protein tyrosine phosphatase, thioredoxin, peroxiredoxin, Nrf2, Ref-1, mitochondrial oxidative stress, apoptosis, aging, p66Shc, iron-sulfur proteins, ATM, DNA damage response, cell proliferation, cell survival
MeSH terms: Amino Acid Sequence, Animals, Gene Expression Regulation, Homeostasis, Humans, Molecular Sequence Data, Oxidation-Reduction, Signal Transduction, Reactive Oxygen Species, Oxidative Stress, Intracellular Signaling Peptides and Proteins

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Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

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