The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
The jun and fos protein families are both required for cell cycle progression in fibroblasts.
Open accessAbstract
The expression of different members of the Jun and Fos families of transcription factors is rapidly induced following serum stimulation of quiescent fibroblasts. To determine whether these proteins are required for cell cycle progression, we microinjected affinity-purified antibodies directed against c-Fos, FosB, Fra-1, c-Jun, JunB, and JunD, and antibodies that recognize either the Fos or the Jun family of proteins, into Swiss 3T3 cells and determined their effects in cell cycle progression by monitoring DNA synthesis. We found that microinjection of anti-Fos and anti-Jun family antibodies efficiently blocked the entrance to the S phase of serum-stimulated or asynchronously growing cells. However, the antibodies against single members of the Fos family only partially inhibited DNA synthesis. In contrast, all three Jun antibodies prevented DNA synthesis more effectively than did any of the anti-Fos antibodies.
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Cites
Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene
Greenberg, M. E., & Ziff, E. B. (1984) · Nature · doi:10.1038/311433a0 · Cited by 3,064
Induction of c-fos gene and protein by growth factors precedes activation of c-myc
Müller, R., Bravo, R., Burckhardt, J., & Curran, T. (1984) · Nature · doi:10.1038/312716a0 · Cited by 1,369
Self-citationMajor nucleolar proteins shuttle between nucleus and cytoplasm
Borer, R. A., Lehner, C. F., Eppenberger, H. M., & Nigg, E. A. (1989) · Cell · doi:10.1016/0092-8674(89)90241-9 · Cited by 1,114
PRIMARY RESPONSE GENES INDUCED BY GROWTH FACTORS AND TUMOR PROMOTERS
Herschman, H. R. (1991) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.60.070191.001433 · Cited by 1,079
c-Jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities
Halazonetis, T. D., Georgopoulos, K., Greenberg, M. E., & Leder, P. (1988) · Cell · doi:10.1016/0092-8674(88)90147-x · Cited by 1,035
Platelet-derived growth factor induces rapid but transient expression of the c-fos gene and protein
Kruijer, W., Cooper, J. A., Hunter, T., & Verma, I. M. (1984) · Nature · doi:10.1038/312711a0 · Cited by 916
DNA binding activities of three murine Jun proteins: Stimulation by Fos
Nakabeppu, Y., Ryder, K., & Nathans, D. (1988) · Cell · doi:10.1016/0092-8674(88)90146-8 · Cited by 781
A gene activated by growth factors is related to the oncogene v-jun.
Ryder, K., Lau, L. F., & Nathans, D. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.5.1487 · Cited by 735
Jun-B differs in its biological properties from, and is a negative regulator of, c-Jun
Chiu, R., Angel, P., & Karin, M. (1989) · Cell · doi:10.1016/0092-8674(89)90754-x · Cited by 688
Induction of proto-oncogene JUN/AP-1 by serum and TPA
Lamph, W. W., Wamsley, P., Sassone-Corsi, P., & Verma, I. M. (1988) · Nature · doi:10.1038/334629a0 · Cited by 658
Cited by
AP-1 as a regulator of cell life and death
Shaulian, E., & Karin, M. (2002) · Nature Cell Biology · doi:10.1038/ncb0502-e131 · Cited by 2,961
AP-1 in cell proliferation and survival
Shaulian, E., & Karin, M. (2001) · Oncogene · doi:10.1038/sj.onc.1204383 · Cited by 1,736
Herdegen, T., & Leah, J. D. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(98)00018-6 · Cited by 1,350
Transforming p21 Mutants and c-Ets-2 Activate the Cyclin D1 Promoter through Distinguishable Regions
Albanese, C., Johnson, J., Watanabe, G., Eklund, N., Vu, D., Arnold, A., & Pestell, R. G. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.40.23589 · Cited by 803
Spatial multi-omic map of human myocardial infarction
Kuppe, C., Ramirez Flores, R. O., Li, Z., Hayat, S., Levinson, R. T., Liao, X., Hannani, M. T., Tanevski, J., Wünnemann, F., Nagai, J. S., et al. (2022) · Nature · doi:10.1038/s41586-022-05060-x · Cited by 772
Metadata
- Authors
- Kovary, K., & Bravo, R.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1991-09
- Volume
- 11
- Issue
- 9
- Pages
- 4466-4472
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W1811606715
- Cited by
- 449
- References
- 35
- FWCI
- 14.08
- Type
- journal article
- Language
- en
- Open access
- green
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- Kovary, K., & Bravo, R. (1991). The jun and fos protein families are both required for cell cycle progression in fibroblasts. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.11.9.4466
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
