The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Identification of a minimal transforming domain of p53: negative dominance through abrogation of sequence-specific DNA binding.
Open accessAbstract
Mutations in the p53 gene are most frequent in cancer. Many p53 mutants possess transforming activity in vitro. In cells transformed by such mutants, the mutant protein is oligomerized with endogenous cell p53. To determine the relevance of oligomerization for transformation, miniproteins containing C-terminal portions of p53 were generated. These miniproteins, although carrying no point mutation, transformed at least as efficiently as full-length mutant p53. Transforming activity was coupled with the ability to oligomerize with wild-type p53, as well as with the ability to abrogate sequence-specific DNA binding by coexpressed wild-type p53. These findings suggest that p53-mediated transformation may operate through a dominant negative mechanism, involving the generation of DNA binding-incompetent oligomers.
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Cites
p53 Mutations in Human Cancers
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The p53 proto-oncogene can act as a suppressor of transformation
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Wild-type p53 activates transcription in vitro
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Cited by
The p53 pathway: positive and negative feedback loops
Harris, S. L., & Levine, A. J. (2005) · Oncogene · doi:10.1038/sj.onc.1208615 · Cited by 1,967
Linking the p53 tumour suppressor pathway to somatic cell reprogramming
Kawamura, T., Suzuki, J., Wang, Y. V., Menendez, S., Morera, L. B., Raya, A., Wahl, G. M., & Belmonte, J. C. I. (2009) · Nature · doi:10.1038/nature08311 · Cited by 1,115
Rapid Destruction of Human Cdc25A in Response to DNA Damage
Mailand, N., Falck, J., Lukas, C., Syljuåsen, R. G., Welcker, M., Bartek, J., & Lukas, J. (2000) · Science · doi:10.1126/science.288.5470.1425 · Cited by 787
Role for the p53 homologue p73 in E2F-1-induced apoptosis
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Central role of p53 in the suntan response and pathologic hyperpigmentation
Cui, R., Widlund, H. R., Feige, E., Lin, J. Y., Wilensky, D. L., Igras, V. E., D'Orazio, J., Fung, C. Y., Schanbacher, C. F., Granter, S. R., et al. (2007) · Cell · doi:10.1016/j.cell.2006.12.045 · Cited by 657
Metadata
- Authors
- Shaulian, E., Zauberman, A., Ginsberg, D., & Oren, M.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1992-12
- Volume
- 12
- Issue
- 12
- Pages
- 5581-5592
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2124380422
- Cited by
- 342
- References
- 5
- FWCI
- 7.34
- Type
- journal article
- Language
- en
- Open access
- green
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- Shaulian, E., Zauberman, A., Ginsberg, D., & Oren, M. (1992). Identification of a minimal transforming domain of p53: negative dominance through abrogation of sequence-specific DNA binding. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.12.12.5581
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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