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The transport of proteins into the nucleus requires the 70-kilodalton heat shock protein or its cytosolic cognate.
Open accessAbstract
The 70-kDa heat shock protein hsp70 and its constitutively expressed cognate, hsc70, are abundant proteins implicated in a number of cellular processes. When a permeabilized cell system for examining the transport of proteins into the nucleus is depleted of hsc70 and hsp70, either by affinity chromatography on ATP-agarose or with antibodies against these proteins, nuclear transport activity is lost. Full activity is restored by the addition of HeLa proteins that bind to ATP-agarose. hsc70 and hsp70 are the active factors, since activity is also fully restored by the addition of either recombinant hsc70 or hsp70 which has been bacterially expressed and highly purified. The restoration of activity is saturable. The transport system requires other cytosolic factors as well, including at least one protein that is sensitive to inactivation by N-ethylmaleimide, but neither hsc70 nor hsp70 is the sensitive protein.
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Citations
Cited by
Steroid Receptor Interactions with Heat Shock Protein and Immunophilin Chaperones*
Pratt, W. B., & Toft, D. O. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.3.0303 · Cited by 1,791
Nucleocytoplasmic transport: the soluble phase
Mattaj, I. W., & Englmeier, L. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.265 · Cited by 1,175
The GTP-binding protein Ran/TC4 is required for protein import into the nucleus
Moore, M. S., & Blobel, G. (1993) · Nature · doi:10.1038/365661a0 · Cited by 759
The antiestrogen ICI 182780 disrupts estrogen receptor nucleocytoplasmic shuttling
Dauvois, S., White, R., & Parker, M. G. (1993) · Journal of Cell Science · doi:10.1242/jcs.106.4.1377 · Cited by 522
Molecular characteristics of immunogenic cancer cell death
Tesniere, A., Panaretakis, T., Kepp, O., Apetoh, L., Ghiringhelli, F., Zitvogel, L., & Kroemer, G. (2008) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4402269 · Cited by 494
Metadata
- Authors
- Shi, Y., & Thomas, J. O.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1992-05
- Volume
- 12
- Issue
- 5
- Pages
- 2186-2192
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2125778361
- Cited by
- 343
- References
- 0
- FWCI
- 13.23
- Type
- journal article
- Language
- en
- Open access
- green
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- Shi, Y., & Thomas, J. O. (1992). The transport of proteins into the nucleus requires the 70-kilodalton heat shock protein or its cytosolic cognate. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.12.5.2186
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