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Pax-8, a Paired Domain-Containing Protein, Binds to a Sequence Overlapping the Recognition Site of a Homeodomain and Activates Transcription from Two Thyroid-Specific Promoters
Open accessAbstract
The Pax-8 gene, a member of the murine family of paired box-containing genes (Pax genes), is expressed in adult thyroid and in cultured thyroid cell lines. The Pax-8 protein binds, through its paired domain, to the promoters of thyroglobulin and thyroperoxidase, genes that are exclusively expressed in the thyroid. In both promoters, the binding site of Pax-8 overlaps with that of TTF-1, a homeodomain-containing protein involved in the activation of thyroid-specific transcription. Pax-8 activates transcription from cotransfected thyroperoxidase and thyroglobulin promoters, indicating that it may be involved in the establishment, control, or maintenance of the thyroid-differentiated phenotype. Thus, the promoters of thyroglobulin and thyroperoxidase represent the first identified natural targets for transcriptional activation by a paired domain-containing protein.
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“TTF1 and PAX8 can activate the transcription of TPO by binding to specific DNA binding sites that overlap each other in the promoter region ( Figure 3C ) (169).”
From Intrathyroidal feedforward and feedback network regulating thyroid hormone synthesis and secretion (2022) · cites this paper as [169]
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Cited by
Sorted by citations
Thyroid transcription factors in development, differentiation and disease
Fernández, L. P., López-Márquez, A., & Santisteban, P. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.186 · Cited by 258
Role of Pax Genes in Eye Evolution
Kozmik, Z., Daube, M., Frei, E., Norman, B., Kos, L., Dishaw, L. J., Noll, M., & Piatigorsky, J. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00325-3 · Cited by 179
Intrathyroidal feedforward and feedback network regulating thyroid hormone synthesis and secretion
Jing, L., & Zhang, Q. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.992883 · Cited by 61
Metadata
- Authors
- Zannini, M., Francis-Lang, H., Plachov, D., & Lauro, R. D.
- Affiliations
- European Molecular Biology Laboratory (DE)
- Institute for Molecular Biology, Salzburg, Austria
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1992-09-01
- Volume
- 12
- Issue
- 9
- Pages
- 4230-4241
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- PMC
- PMC360331
- OpenAlex
- W2100992077
- Cited by
- 300
- References
- 0
- Citations by year
- 2025: 2 · 2024: 5 · 2023: 3 · 2022: 5 · 2021: 1 · 2020: 5 · 2019: 8 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 6 · 2014: 7 · 2013: 5 · 2012: 7
- FWCI
- 14.96
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Molecular and Cellular Biology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- PAX8, paired box genes, paired domain, transcriptional activation, thyroglobulin promoter, TTF-1, homeodomain, thyroid differentiation, thyroid cell lines
- MeSH terms
- Animals, Base Sequence, Binding Sites, DNA, HeLa Cells, Humans, Molecular Sequence Data, Peroxidases, Promoter Regions, Genetic, Thyroglobulin, Thyroid Gland, Transcription Factors, Transcription, Genetic, Blotting, Northern, Rats
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