Role of Pax Genes in Eye Evolution

Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells

Schreiber, E. H., Matthias, P., Müller, M. M., & Schaffner, W. (1989) · Nucleic Acids Research · doi:10.1093/nar/17.15.6419 · Cited by 4,179 · see citing works

Induction of Ectopic Eyes by Targeted Expression of the <i>eyeless</i> Gene in <i>Drosophila</i>

Halder, G., Callaerts, P., & Gehring, W. J. (1995) · Science · doi:10.1126/science.7892602 · Cited by 1,573 · see citing works

Commitment to the B-lymphoid lineage depends on the transcription factor Pax5

Nutt, S. L., Heavey, B., Rolink, A. G., & Busslinger, M. (1999) · Nature · doi:10.1038/44076 · Cited by 1,179 · see citing works

Homology of the <i>eyeless</i> Gene of <i>Drosophila</i> to the <i>Small eye</i> Gene in Mice and <i>Aniridia</i> in Humans

Quiring, R., Walldorf, U., Kloter, U., & Gehring, W. J. (1994) · Science · doi:10.1126/science.7914031 · Cited by 1,100 · see citing works

Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP

Urbánek, P. (1994) · Cell · doi:10.1016/0092-8674(94)90079-5 · Cited by 795 · see citing works

[22] Detection of messenger RNA by in Situ hybridization to tissue sections and whole mounts

Wilkinson, D. G., & Nieto, M. A. (1993) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(93)25025-w · Cited by 794 · see citing works

LENS CRYSTALLINS: THE EVOLUTION AND EXPRESSION OF PROTEINS FOR A HIGHLY SPECIALIZED TISSUE

Wistow, G. J., & Piatigorsky, J. (1988) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.57.070188.002403 · Cited by 775 · see citing works

Pax 6: mastering eye morphogenesis and eye evolution

Gehring, W. J., & Ikeo, K. (1999) · Trends in Genetics · doi:10.1016/s0168-9525(99)01776-x · Cited by 758 · see citing works

Follicular cells of the thyroid gland require Pax8 gene function

Mansouri, A., Chowdhury, K., & Gruß, P. (1998) · Nature Genetics · doi:10.1038/ng0598-87 · Cited by 620 · see citing works

Pax2 contributes to inner ear patterning and optic nerve trajectory

Torres, M., Gómez‐Pardo, E., & Gruß, P. (1996) · Development · doi:10.1242/dev.122.11.3381 · Cited by 603 · see citing works

The Eye-Specification Proteins So and Eya Form a Complex and Regulate Multiple Steps in Drosophila Eye Development

Pignoni, F., Hu, B., Zavitz, K. H., Xiao, J. Y., Garrity, P., & Zipursky, S. L. (1997) · Cell · doi:10.1016/s0092-8674(00)80480-8 · Cited by 591 · see citing works

Nephric lineage specification by Pax2 and Pax8Preprint

Bouchard, M., Souabni, A., Mandler, M., Neubüser, A., & Busslinger, M. (2002) · Genes & Development · doi:10.1101/gad.240102 · Cited by 550 · see citing works

Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis.Preprint

Adams, B., Dörfler, P., Aguzzi, A., Kozmík, Z., Urbánek, P., Maurer-Fogy, I., & Busslinger, M. (1992) · Genes & Development · doi:10.1101/gad.6.9.1589 · Cited by 525 · see citing works

Conservation of a large protein domain in the segmentation gene paired and in functionally related genes of Drosophila

Bopp, D., Burri, M., Baumgartner, S., Frigerio, G., & Noll, M. (1986) · Cell · doi:10.1016/0092-8674(86)90818-4 · Cited by 486 · see citing works

Getting your Pax straight: Pax proteins in development and disease

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A pessimistic estimate of the time required for an eye to evolve

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Pax6 and SOX2 form a co-DNA-binding partner complex that regulates initiation of lens developmentPreprint

Kamachi, Y., Uchikawa, M., Tanouchi, A., Sekido, R., & Kondoh, H. (2001) · Genes & Development · doi:10.1101/gad.887101 · Cited by 394 · see citing works

DNA sequence recognition by Pax proteins: bipartite structure of the paired domain and its binding site.Preprint

Czerny, T., Schaffner, G., & Busslinger, M. (1993) · Genes & Development · doi:10.1101/gad.7.10.2048 · Cited by 392 · see citing works

Dachshund and Eyes Absent Proteins Form a Complex and Function Synergistically to Induce Ectopic Eye Development in Drosophila

Chen, R., Amoui, M., Zhang, Z., & Mardon, G. (1997) · Cell · doi:10.1016/s0092-8674(00)80481-x · Cited by 389 · see citing works

Long-term in vivo reconstitution of T-cell development by Pax5-deficient B-cell progenitors

Rolink, A. G., Nutt, S. L., Melchers, F., & Busslinger, M. (1999) · Nature · doi:10.1038/44164 · Cited by 386 · see citing works

twin of eyeless, a Second Pax-6 Gene of Drosophila, Acts Upstream of eyeless in the Control of Eye Development

Czerny, T., Halder, G. A., Kloter, U., Souabni, A., Gehring, W. J., & Busslinger, M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80457-8 · Cited by 381 · see citing works

Phylogeny of Medusozoa and the evolution of cnidarian life cycles

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The paired box encodes a second DNA-binding domain in the paired homeo domain protein.Preprint

Treisman, J. E., Harris, E., & Desplan, C. (1991) · Genes & Development · doi:10.1101/gad.5.4.594 · Cited by 347 · see citing works

Characterization of three novel members of the zebrafish Pax2/5/8 family: dependency of Pax5 and Pax8 expression on the Pax2.1 (noi) function

Pfeffer, P. L., Gerster, T., Lun, K., Brand, M., & Busslinger, M. (1998) · Development · doi:10.1242/dev.125.16.3063 · Cited by 338 · see citing works

Evolution and role of Pax genes

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The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP.

Kozmík, Z., Wang, S., Dörfler, P., et al. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.6.2662 · Cited by 329 · see citing works

Crystal structure of a paired domain-DNA complex at 2.5 å resolution reveals structural basis for pax developmental mutations

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Crystal structure of the human Pax6 paired domain-DNA complex reveals specific roles for the linker region and carboxy-terminal subdomain in DNA bindingPreprint

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Human homologs of a Drosophila Enhancer of Split gene product define a novel family of nuclear proteins

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Pax-8, a Paired Domain-Containing Protein, Binds to a Sequence Overlapping the Recognition Site of a Homeodomain and Activates Transcription from Two Thyroid-Specific Promoters

Zannini, M., Francis-Lang, H., Plachov, D., & Lauro, R. D. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.9.4230 · Cited by 300 · see citing works

DNA-Binding and Transactivation Properties of Pax-6: Three Amino Acids in the Paired Domain Are Responsible for the Different Sequence Recognition of Pax-6 and BSAP (Pax-5)

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Lens development and crystallin gene expression: many roles for Pax‐6

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Combinatorial Signaling in the Specification of Unique Cell Fates

Flores, G. V., Duan, H., Yan, H., Nagaraj, R., Fu, W., Zou, Y. S., Noll, M., & Banerjee, U. K. (2000) · Cell · doi:10.1016/s0092-8674(00)00106-9 · Cited by 261 · see citing works

Transcriptional repression by Pax5 (BSAP) through interaction with corepressors of the Groucho family

Eberhard, D., Jiménez, G., Heavey, B., & Busslinger, M. (2000) · The EMBO Journal · doi:10.1093/emboj/19.10.2292 · Cited by 256 · see citing works

Role of Olf-1 and Pax-6 Transcription Factors in Neurodevelopment

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Evolution of eye lens crystallins: the stress connection

JONG, W. W. D., Hendriks, W. J. A. J., Mulders, J. W. M., & BLOEMENDAL, H. (1989) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(89)90009-1 · Cited by 204 · see citing works

Direct regulation of rhodopsin 1 by Pax-6/eyeless in Drosophila: evidence for a conserved function in photoreceptors.

Sheng, G., Thouvenot, E., Schmucker, D., Wilson, D. S., & Desplan, C. (1997) · Genes &amp; Development · doi:10.1101/gad.11.9.1122 · Cited by 201 · see citing works

Pax6: more than meets the eye

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Development of pigment-cup eyes in the polychaete<i>Platynereis dumerilii</i>and evolutionary conservation of larval eyes in Bilateria

Arendt, D., Tessmar, K., de Campos-Baptista, M.-I. M., Dorresteijn, A., & Wittbrodt, J. (2002) · Development · doi:10.1242/dev.129.5.1143 · Cited by 192 · see citing works

The genetic control of eye development and its implications for the evolution of the various eye-types.

Gehring, W. J. (2002) · International Journal of Developmental Biology · doi:10.1387/ijdb.11902689 · Cited by 184 · see citing works

Zebrafish contains two Pax6 genes involved in eye development1The sequence reported in this paper has been deposited in the GenBank data base (accession no. AF061252).1

Nornes, S., Clarkson, M. J., Mikkola, I., Pedersen, M., Bardsley, A., Martı́nez-Barberá, J. P., Krauss, S. J. K., & Johansen, T. (1998) · Mechanisms of Development · doi:10.1016/s0925-4773(98)00156-7 · Cited by 171 · see citing works

Cooperation of Pax2 and Pax5 in midbrain and cerebellum development

Urbánek, P., Fetka, I., Meisler, M. H., & Busslinger, M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.11.5703 · Cited by 162 · see citing works

The Pax2 homolog sparkling is required for development of cone and pigment cells in theDrosophila eyePreprint

Fu, W., & Noll, M. (1997) · Genes & Development · doi:10.1101/gad.11.16.2066 · Cited by 157 · see citing works

Retinoic acid X receptor in the diploblast, Tripedalia cystophora

Kostrouch, Z., Kostrouchová, M., Love, W. K., Jannini, E. A., Piatigorsky, J., & Rall, J. E. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.23.13442 · Cited by 153 · see citing works

The genetic control of eye development and its implications for the evolution of the various eye-types

Gehring, W. J. (2001) · Zoology · doi:10.1078/0944-2006-00022 · Cited by 151 · see citing works

Lens Crystallins of Invertebrates: Diversity and Recruitment from Detoxification Enzymes and Novel Proteins

Tomarev, S. I., & Piatigorsky, J. (1996) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1996.00449.x · Cited by 146 · see citing works

C‐terminal activating and inhibitory domains determine the transactivation potential of BSAP (Pax‐5), Pax‐2 and Pax‐8.

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Cnidarians as a model system for understanding evolution and regeneration

Galliot, B., & Schmid, V. J. (2002) · The International Journal of Developmental Biology · doi:10.1387/ijdb.11902686 · Cited by 143 · see citing works

Conserved biological function between Pax- 2 and Pax- 5 in midbrain and cerebellum development: Evidence from targeted mutations

Schwarz, M. K., Álvarez-Bolado, G., Urbánek, P., Busslinger, M., & Gruß, P. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.26.14518 · Cited by 142 · see citing works

Essential Requirement for Pax6 in Control of Enteroendocrine Proglucagon Gene Transcription

Hill, M. E., Asa, S. L., & Drucker, D. J. (1999) · Molecular Endocrinology · doi:10.1210/mend.13.9.0340 · Cited by 134 · see citing works

Pax gene diversity in the basal cnidarian Acropora millepora (Cnidaria, Anthozoa): Implications for the evolution of the Pax gene family

Miller, D. J., Hayward, D. C., Reece-Hoyes, J. S., Scholten, I., Catmull, J., Gehring, W. J., Callaerts, P., Larsen, J. E., & Ball, E. E. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.9.4475 · Cited by 119 · see citing works

Evolutionary Significance of Photoreceptors: In Retrospect

Eakin, R. M. (1979) · American Zoologist · doi:10.1093/icb/19.2.647 · Cited by 106 · see citing works

Sponge Pax cDNA Related to Pax-2/5/8 and Ancient Gene Duplications in the Pax Family

Hoshiyama, D., Suga, H., Iwabe, N., Koyanagi, M., Nikoh, N., Kuma, K., Matsuda, F., Honjo, T., & Miyata, T. (1998) · Journal of Molecular Evolution · doi:10.1007/pl00006421 · Cited by 99 · see citing works

The genetic network of prototypic planarian eye regeneration is Pax6 independent

Pineda, D., Rossi, L., Batistoni, R., Salvetti, A., Marsal, M., Gremigni, V., Falleni, A., González-Linares, J., Deri, P., & Saló, E. (2002) · Development · doi:10.1242/dev.129.6.1423 · Cited by 99 · see citing works

Evolution of functional diversification of the paired box (Pax) DNA- binding domains

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Dissection of the Transactivation Function of the Transcription Factor Encoded by the Eye Developmental Gene PAX6

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Evolution of paired domains: Isolation and sequencing of jellyfish and hydra Pax genes related to Pax-5 and Pax-6

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The cellular eye lens and crystallins of cubomedusan jellyfish

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An essential role for the Drosophila Pax2 homolog in the differentiation of adult sensory organs

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shaven and sparkling are mutations in separate enhancers of the Drosophila Pax2 homolog

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Mapping of Pax-2 Transcription Activation Domains

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The characterization of novel Pax genes of the sea urchin and Drosophila reveal an ancient evolutionary origin of the Pax2/5/8 subfamily

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The eyeless homeodomain is dispensable for eye development in DrosophilaPreprint

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J1-crystallins of the cubomedusan jellyfish lens constitute a novel family encoded in at least three intronless genes

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A conserved regulatory element present in all Drosophila rhodopsin genes mediates Pax6 functions and participates in the fine-tuning of cell-specific expression

Papatsenko, D., Nazina, A. G., & Desplan, C. (2001) · Mechanisms of Development · doi:10.1016/s0925-4773(00)00581-5 · Cited by 57 · see citing works

Structure and Expression of the Scallop Ω-Crystallin Gene

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Characterization and expression analysis of an ancestor-type Pax gene in the hydrozoan jellyfish Podocoryne carnea

Gröger, H., Callaerts, P., Gehring, W. J., & Schmid, V. J. (2000) · Mechanisms of Development · doi:10.1016/s0925-4773(00)00286-0 · Cited by 53 · see citing works

J3-crystallin of the jellyfish lens: Similarity to saposins

Piatigorsky, J., Norman, B., Dishaw, L. J., Kos, L., Horwitz, J., Steinbach, P. J., & Kozmík, Z. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.231310698 · Cited by 51 · see citing works

Developmental and tissue-specific regulation of a novel transcription factor of the sea urchin.Preprint

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Isolation of Cladonema Pax-B Genes and Studies of the DNA-Binding Properties of Cnidarian Pax Paired Domains

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Functional equivalency of amphioxus and vertebrate Pax258 transcription factors suggests that the activation of mid-hindbrain specific genes in vertebrates occurs via the recruitment of Pax regulatory elements

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Lens Crystallins

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Evolutionary crossroads in developmental biology: Cnidaria

Technau, U., & Steele, R. E. (2011) · Development · doi:10.1242/dev.048959 · Cited by 274 · see citing works

Origins of neurogenesis, a cnidarian view

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Assembly of the cnidarian camera-type eye from vertebrate-like components

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A simple plan-Cnidarians and the origins of developmental mechanisms

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Evolution of eumetazoan nervous systems: insights from cnidarians

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MOLECULAR PALAEOBIOLOGY

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The evolution of eyes: major steps. The Keeler lecture 2017: centenary of Keeler Ltd

Schwab, I. R. (2018) · Eye · doi:10.1038/eye.2017.226 · Cited by 44 · see citing works

A Short History of Nearly Every Sense—The Evolutionary History of Vertebrate Sensory Cell Types

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Punctuated Emergences of Genetic and Phenotypic Innovations in Eumetazoan, Bilaterian, Euteleostome, and Hominidae Ancestors

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The Rx homeobox gene is essential for vertebrate eye development

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Specification of the vertebrate eye by a network of eye field transcription factors

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The compound lens eye of Strepsiptera: morphological development of larvae and pupae

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Early Eye Development: Specification and Determination

Mishra, A. K., & Sprecher, S. G. (2020) · Springer eBooks · doi:10.1007/978-3-030-42246-2_1 · Cited by 5 · see citing works

The Eye-Specification Proteins So and Eya Form a Complex and Regulate Multiple Steps in Drosophila Eye Development

Pignoni, F., Hu, B., Zavitz, K. H., Xiao, J. Y., Garrity, P., & Zipursky, S. L. (1997) · Cell · doi:10.1016/s0092-8674(00)80480-8 · Cited by 591 · see citing works