The DOI matches its Crossref record; 117 of the 117 references it cites were found in a registry or an index.
A novel inhibitor of cyclin-Cdk activity detected in transforming growth factor beta-arrested epithelial cells.
Open accessAbstract
Transforming growth factor beta (TGF-beta) is a potent inhibitor of epithelial cell growth. Cyclins E and A in association with Cdk2 have been shown to play a role in the G1-to-S phase transition in mammalian cells. We have studied the effects of TGF-beta-mediated growth arrest on G1/S cyclins E and A. Inhibition of cyclin A-associated kinase by TGF-beta is primarily due to a decrease in cyclin A mRNA and protein. By contrast, while TGF-beta inhibits accumulation of cyclin E mRNA, the reduction in cyclin E protein is minimal. Instead, we find that the activation of cyclin E-associated kinase that normally accompanies the G1-to-S phase transition is inhibited. A novel inhibitor of cyclin-Cdk complexes was detected in TGF-beta-treated cell lysates. Inhibition is mediated by a heat-stable protein that targets both Cdk2 and Cdc2 kinases. In G0-arrested cells, a similar inhibitor of Cdk2 kinase was detected. These data suggest the existence of an inhibitor of cyclin-dependent kinases induced under different conditions to mediate antiproliferative responses.
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Cites
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The retinoblastoma protein and cell cycle control
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Self-citation
Metadata
- Authors
- Slingerland, J. M., Hengst, L., Pan, C. H., Alexander, D., Stampfer, M. R., & Reed, S. I.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1994-06
- Volume
- 14
- Issue
- 6
- Pages
- 3683-3694
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W1834547194
- Cited by
- 324
- References
- 117
- FWCI
- 14.62
- Type
- journal article
- Language
- en
- Open access
- green
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- Slingerland, J. M., Hengst, L., Pan, C. H., Alexander, D., Stampfer, M. R., & Reed, S. I. (1994). A novel inhibitor of cyclin-Cdk activity detected in transforming growth factor beta-arrested epithelial cells. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.14.6.3683
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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