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An Interaction between the DNA Repair Factor XPA and Replication Protein A Appears Essential for Nucleotide Excision Repair
Open accessAbstract
Replication protein A (RPA) is required for simian virus 40-directed DNA replication in vitro and for nucleotide excision repair (NER). Here we report that RPA and the human repair protein XPA specifically interact both in vitro and in vivo. Mapping of the RPA-interactive domains in XPA revealed that both of the largest subunits of RPA, RPA-70 and RPA-34, interact with XPA at distinct sites. A domain involved in mediating the interaction with RPA-70 was located between XPA residues 153 and 176. Deletion of highly conserved motifs within this region identified two mutants that were deficient in binding RPA in vitro and highly defective in NER both in vitro and in vivo. A second domain mediating the interaction with RPA-34 was identified within the first 58 residues in XPA. Deletion of this region, however, only moderately affects the complementing activity of XPA in vivo. Finally, the XPA-RPA complex is shown to have a greater affinity for damaged DNA than XPA alone. Taken together, these results indicate that the interaction between XPA and RPA is required for NER but that only the interaction with RPA-70 is essential.
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Cites
The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA
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Reconstitution of Human DNA Repair Excision Nuclease in a Highly Defined System
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RPA involvement in the damage-recognition and incision steps of nucleotide excision repair
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Preferential binding of the xeroderma pigmentosum group A complementing protein to damaged DNA
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Cited by
Wold, M. S. (1997) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.66.1.61 · Cited by 1,444
Flexible nets: The roles of intrinsic disorder in protein interaction networks
Dunker, A. K., Cortese, M. S., Romero, P., Iakoucheva, L. M., & Uversky, V. N. (2005) · The FEBS Journal · doi:10.1111/j.1742-4658.2005.04948.x · Cited by 1,122
Molecular mechanism of nucleotide excision repair
de Laat, W. L., Jaspers, N. G. J., & Hoeijmakers, J. H. J. (1999) · Genes & Development · doi:10.1101/gad.13.7.768 · Cited by 1,122
Nucleotide Excision Repair in Eukaryotes
Scharer, O. D. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a012609 · Cited by 801
Molecular Mechanisms of Mammalian Global Genome Nucleotide Excision Repair
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Metadata
- Authors
- Li, L., Lu, X., Peterson, C. A., & Legerski, R. J.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1995-10-01
- Volume
- 15
- Issue
- 10
- Pages
- 5396-5402
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2142355539
- Cited by
- 254
- References
- 5
- FWCI
- 7.46
- Type
- journal article
- Language
- en
- Open access
- green
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- Li, L., Lu, X., Peterson, C. A., & Legerski, R. J. (1995). An Interaction between the DNA Repair Factor XPA and Replication Protein A Appears Essential for Nucleotide Excision Repair. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.15.10.5396
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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