The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Nucleolar Localization of Parathyroid Hormone-Related Peptide Enhances Survival of Chondrocytes under Conditions That Promote Apoptotic Cell Death
Open accessAbstract
Parathyroid hormone-related peptide (PTHrP) is a mediator of cellular growth and differentiation as well as a cause of malignancy-induced hypercalcemia. Most of the actions of PTHrP have been attributed to its interaction with a specific cell surface receptor that binds the N-terminal domain of the protein. Here we present evidence that PTHrP promotes some of its cellular effects by translocating to the nucleolus. Localization of transiently expressed PTHrP to the nucleolus was dependent on the presence of a highly basic region at the carboxyl terminus of the molecule that bears homology to nucleolar targeting sequences identified within human retroviral (human immunodeficiency virus type 1 and human T-cell leukemia virus type 1) regulatory proteins. Endogenous PTHrP also localized to the nucleolus in osseous cells in vitro and in vivo. Moreover, expression of PTHrP in chondrocytic cells (CFK2) delayed apoptosis induced by serum deprivation, and this effect depended on the presence of an intact nucleolar targeting signal. The present findings demonstrate a unique intracellular mode of PTHrP action and a novel mechanism by which this peptide growth factor may modulate programmed cell death.
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Parathyroid hormone and parathyroid hormone-related peptide, and their receptors
Gensure, R. C., Gardella, T. J., & Jüppner, H. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.11.069 · Cited by 301
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Metadata
- Authors
- Henderson, J. E., Amizuka, N., Warshawsky, H., Biasotto, D., Lanske, B. M. K., Goltzman, D., & Karaplis, A. C.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1995-08-01
- Volume
- 15
- Issue
- 8
- Pages
- 4064-4075
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2160753380
- Cited by
- 334
- References
- 50
- FWCI
- 17.61
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Nucleolar Localization of Parathyroid Hormone-Related Peptide Enhances Survival of Chondrocytes under Conditions That Promote Apoptotic Cell Death. https://app.cochat.ai/papers/10.1128/mcb.15.8.4064
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- Henderson, J. E., Amizuka, N., Warshawsky, H., Biasotto, D., Lanske, B. M. K., Goltzman, D., & Karaplis, A. C. (1995). Nucleolar Localization of Parathyroid Hormone-Related Peptide Enhances Survival of Chondrocytes under Conditions That Promote Apoptotic Cell Death. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.15.8.4064
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
