The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Bcl-2 Lies Downstream of Parathyroid Hormone–related Peptide in a Signaling Pathway That Regulates Chondrocyte Maturation during Skeletal Development
Open accessAbstract
Parathyroid hormone–related peptide (PTHrP) appears to play a major role in skeletal development. Targeted disruption of the PTHrP gene in mice causes skeletal dysplasia with accelerated chondrocyte maturation (Amizuka, N., H. Warshawsky, J.E. Henderson, D. Goltzman, and A.C. Karaplis. 1994. J. Cell Biol. 126:1611–1623; Karaplis, A.C., A. Luz, J. Glowacki, R.T. Bronson, V.L.J. Tybulewicz, H.M. Kronenberg, and R.C. Mulligan. 1994. Genes Dev. 8: 277–289). A constitutively active mutant PTH/PTHrP receptor has been found in Jansen-type human metaphyseal chondrodysplasia, a disease characterized by delayed skeletal maturation (Schipani, E., K. Kruse, and H. Jüppner. 1995. Science (Wash. DC). 268:98– 100). The molecular mechanisms by which PTHrP affects this developmental program remain, however, poorly understood. We report here that PTHrP increases the expression of Bcl-2, a protein that controls programmed cell death in several cell types, in growth plate chondrocytes both in vitro and in vivo, leading to delays in their maturation towards hypertrophy and apoptotic cell death. Consequently, overexpression of PTHrP under the control of the collagen II promoter in transgenic mice resulted in marked delays in skeletal development. As anticipated from these results, deletion of the gene encoding Bcl-2 leads to accelerated maturation of chondrocytes and shortening of long bones. Thus, Bcl-2 lies downstream of PTHrP in a pathway that controls chondrocyte maturation and skeletal development.
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Cites
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Bcl-2 functions in an antioxidant pathway to prevent apoptosis
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bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death
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Cited by
Sahni, M., Ambrosetti, D.-C., Mansukhani, A., Gertner, R., Levy, D., & Basilico, C. (1999) · Genes & Development · doi:10.1101/gad.13.11.1361 · Cited by 375
Brew, C. J., Clegg, P. D., Boot-Handford, R. P., Andrew, J. G., & Hardingham, T. (2010) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2008.097139 · Cited by 134
Leptin reverses the inhibitory effect of caloric restriction on longitudinal growth
Gat-Yablonski, G., Ben-Ari, T., Shtaif, B., Potievsky, O., Moran, O., Eshet, R., Maor, G., Segev, Y., & Phillip, M. (2004) · Endocrinology · doi:10.1210/en.2003-0910 · Cited by 106
Metadata
- Authors
- Amling, M., Neff, L., Tanaka, S., Inoue, D., Kuida, K., Weir, E., Philbrick, W. M., Broadus, A. E., & Baron, R.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 1997-01-13
- Volume
- 136
- Issue
- 1
- Pages
- 205-213
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2170335058
- Cited by
- 304
- References
- 42
- FWCI
- 9.56
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Bcl-2 Lies Downstream of Parathyroid Hormone–related Peptide in a Signaling Pathway That Regulates Chondrocyte Maturation during Skeletal Development. https://app.cochat.ai/papers/10.1083/jcb.136.1.205
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- Amling, M., Neff, L., Tanaka, S., Inoue, D., Kuida, K., Weir, E., Philbrick, W. M., Broadus, A. E., & Baron, R. (1997). Bcl-2 Lies Downstream of Parathyroid Hormone–related Peptide in a Signaling Pathway That Regulates Chondrocyte Maturation during Skeletal Development. The Journal of Cell Biology. https://doi.org/10.1083/jcb.136.1.205
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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