The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Evidence for Two Catalytically Active Kinase Domains in pp90 rsk
Open accessAbstract
Mitogen-activated protein kinase and one of its targets, pp90rsk (ribosomal S6 kinase [RSK]), represent two serine/threonine kinases in the Ras-activated signalling cascade that are capable of directly regulating gene expression. pp90rsk has been shown to have two highly conserved and distinct catalytic domains. However, whether both domains are active and which domain is responsible for its various identified phosphotransferase activities have not been determined. Here we demonstrate that the N-terminal domain is responsible for its phosphotransferase activity towards a variety of substrates which contain an RXXS motif at the site of in vitro phosphorylation, including serum response factor, c-Fos, Nur77, and the 40S ribosomal protein S6. We also provide evidence that the C-terminal domain is catalytically active and can be further activated by mitogen-activated protein kinase phosphorylation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Sutherland, C., Leighton, I. A., & Cohen, P. (1993) · Biochemical Journal · doi:10.1042/bj2960015 · Cited by 903
Cited by
Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases
Cargnello, M., & Roux, P. P. (2011) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00031-10 · Cited by 3,274
Signal Transduction through MAP Kinase Cascades
(1998) · Advances in Cancer Research · doi:10.1016/s0065-230x(08)60765-4 · Cited by 1,759
The RSK family of kinases: emerging roles in cellular signalling
Anjum, R., & Blenis, J. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2509 · Cited by 777
Self-citationTwo PTP receptors mediate CSPG inhibition by convergent and divergent signaling pathways in neurons
Ohtake, Y., Wong, D., Abdul-Muneer, P. M., Selzer, M. E., & Li, S. (2016) · Scientific Reports · doi:10.1038/srep37152 · Cited by 59
Structural basis for activation of the autoinhibitory C-terminal kinase domain of p90 RSK2
Malakhova, M., Tereshko, V., Lee, S.-Y., Yao, K., Cho, Y.-Y., Bode, A., & Dong, Z. (2008) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1347 · Cited by 48
Metadata
- Authors
- Fisher, T. L., & Blenis, J.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1996-03
- Volume
- 16
- Issue
- 3
- Pages
- 1212-1219
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W1860814838
- Cited by
- 195
- References
- 1
- FWCI
- 3.71
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Evidence for Two Catalytically Active Kinase Domains in pp90 rsk. https://app.cochat.ai/papers/10.1128/mcb.16.3.1212
- The paper
- Fisher, T. L., & Blenis, J. (1996). Evidence for Two Catalytically Active Kinase Domains in pp90 rsk. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.16.3.1212
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
