The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Truncated Mammalian Notch1 Activates CBF1/RBPJk-Repressed Genes by a Mechanism Resembling That of Epstein-Barr Virus EBNA2
Open accessAbstract
The Notch/Lin-12/Glp-1 receptor family participates in cell-cell signaling events that influence cell fate decisions. Although several Notch homologs and receptor ligands have been identified, the nuclear events involved in this pathway remain incompletely understood. A truncated form of Notch, consisting only of the intracellular domain (NotchIC), localizes to the nucleus and functions as an activated receptor. Using both an in vitro binding assay and a cotransfection assay based on the two-hybrid principle, we show that mammalian NotchIC interacts with the transcriptional repressor CBF1, which is the human homolog of Drosophila Suppressor of Hairless. Cotransfection assays using segments of mouse NotchIC and CBF1 demonstrated that the N-terminal 114-amino-acid region of mouse NotchIC contains the CBF1 interactive domain and that the cdc10/ankyrin repeats are not essential for this interaction. This result was confirmed in immunoprecipation assays in which the N-terminal 114-amino-acid segment of NotchIC, but not the ankyrin repeat region, coprecipitated with CBF1. Mouse NotchIC itself is targeted to the transcriptional repression domain (aa179 to 361) of CBF1. Furthermore, transfection assays in which mouse NotchIC was targeted through Gal4-CBF1 or through endogenous cellular CBF1 indicated that NotchIC transactivates gene expression via CBF1 tethering to DNA. Transactivation by NotchIC occurs partially through abolition of CBF1-mediated repession. This same mechanism is used by Epstein-Barr virus EBNA2. Thus, mimicry of Notch signal transduction is involved in Epstein-Barr virus-driven immortalization.
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Cited by
Notch signaling: control of cell communication and cell fate
Lai, E. C. (2004) · Development · doi:10.1242/dev.01074 · Cited by 1,050
Fringe is a glycosyltransferase that modifies Notch
Moloney, D. J., Panin, V. M., Johnston, S. H., Chen, J., Shao, L., Wilson, R., Wang, Y., Stanley, P., Irvine, K. D., Haltiwanger, R. S., et al. (2000) · Nature · doi:10.1038/35019000 · Cited by 852
Conservation of the Notch signalling pathway in mammalian neurogenesis
Luis de la Pompa, J., Wakeham, A., Correia, K. M., Samper, E., Brown, S., Aguilera, R. J., Nakano, T., Honjo, T., Mak, T. W., Rossant, J., et al. (1997) · Development · doi:10.1242/dev.124.6.1139 · Cited by 624
Tonon, G., Modi, S., Wu, L., Kubo, A., Coxon, A. B., Komiya, T., O'Neil, K., Stover, K., El-Naggar, A., Griffin, J. D., et al. (2003) · Nature Genetics · doi:10.1038/ng1083 · Cited by 567
Crystal Structure of the CSL-Notch-Mastermind Ternary Complex Bound to DNA
Wilson, J. J., & Kovall, R. A. (2006) · Cell · doi:10.1016/j.cell.2006.01.035 · Cited by 371
Metadata
- Authors
- Hsieh, J. J.-D., Henkel, T., Salmon, P., Robey, E., Peterson, M. G., & Hayward, S. D.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1996-03
- Volume
- 16
- Issue
- 3
- Pages
- 952-959
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W1911156364
- Cited by
- 451
- References
- 51
- FWCI
- 8.53
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Truncated Mammalian Notch1 Activates CBF1/RBPJk-Repressed Genes by a Mechanism Resembling That of Epstein-Barr Virus EBNA2. https://app.cochat.ai/papers/10.1128/mcb.16.3.952
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- Hsieh, J. J.-D., Henkel, T., Salmon, P., Robey, E., Peterson, M. G., & Hayward, S. D. (1996). Truncated Mammalian Notch1 Activates CBF1/RBPJk-Repressed Genes by a Mechanism Resembling That of Epstein-Barr Virus EBNA2. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.16.3.952
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