The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.
Conservation of the Notch signalling pathway in mammalian neurogenesis
Abstract
The Notch pathway functions in multiple cell fate determination processes in invertebrate embryos, including the decision between the neuroblast and epidermoblast lineages in Drosophila. In the mouse, targeted mutation of the Notch pathway genes Notch1 and RBP-Jk has demonstrated a role for these genes in somite segmentation, but a function in neurogenesis and in cell fate decisions has not been shown. Here we show that these mutations lead to altered expression of the Notch signalling pathway homologues Hes-5, Mash-1 and Dll1, resulting in enhanced neurogenesis. Precocious neuronal differentiation is indicated by the expanded expression domains of Math4A, neuroD and NSCL-1. The RBP-Jk mutation has stronger effects on expression of these genes than does the Notch1 mutation, consistent with functional redundancy of Notch genes in neurogenesis. Our results demonstrate conservation of the Notch pathway and its regulatory mechanisms from fly to mouse, and support a role for the murine Notch signalling pathway in the regulation of neural stem cell differentiation.
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Cites
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Conversion of Xenopus Ectoderm into Neurons by NeuroD, a Basic Helix-Loop-Helix Protein
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Cited by
Senescence is a developmental mechanism that contributes to embryonic growth and patterning
Storer, M., Mas, A., Robert-Moreno, A., Pecoraro, M., Ortells, M. C., Di Giacomo, V., Yosef, R., Pilpel, N., Krizhanovsky, V., Sharpe, J., et al. (2013) · Cell · doi:10.1016/j.cell.2013.10.041 · Cited by 1,186
Hypoxia requires Notch signaling to maintain the undifferentiated cell state
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Hes1 and Hes5 as Notch effectors in mammalian neuronal differentiation
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Metadata
- Authors
- Luis de la Pompa, J., Wakeham, A., Correia, K. M., Samper, E., Brown, S., Aguilera, R. J., Nakano, T., Honjo, T., Mak, T. W., Rossant, J., & Conlon, R. A.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1997-03-15
- Volume
- 124
- Issue
- 6
- Pages
- 1139-1148
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2118589362
- Cited by
- 624
- References
- 67
- FWCI
- 11.59
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Conservation of the Notch signalling pathway in mammalian neurogenesis. https://app.cochat.ai/papers/10.1242/dev.124.6.1139
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- Luis de la Pompa, J., Wakeham, A., Correia, K. M., Samper, E., Brown, S., Aguilera, R. J., Nakano, T., Honjo, T., Mak, T. W., Rossant, J., & Conlon, R. A. (1997). Conservation of the Notch signalling pathway in mammalian neurogenesis. Development. https://doi.org/10.1242/dev.124.6.1139
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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