The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
A Mutant p53 That Discriminates between p53-Responsive Genes Cannot Induce Apoptosis
Open accessAbstract
Human wild-type (wt) p53 can induce apoptosis in transiently transfected H1299 cells maintained at 37 degrees C, whereas tumor-derived mutant forms of p53 (with the mutation Ala-143, His-175, or Trp-248) fail to do so. At 37 degrees C, p53 with a mutation to Ala at amino acid 143 (p53Ala143) was transcriptionally inactive. However, at 32 degrees C, p53Ala143 strongly activated transcription from several physiologically relevant p53-responsive promoters, to extents similar or greater than that of wt p53. Unexpectedly, p53Ala143 was defective in inducing apoptosis in H1299 cells at 32 degrees C. Concomitantly with the loss of apoptotic activity, p53Ala143 was found to be deficient in its ability to activate transcription from the p53-responsive portions of the Bax and insulin-like growth factor-binding protein 3 gene promoters. It is proposed that there may exist distinct classes of p53-responsive promoters, whose ability to be activated by p53 can be regulated differentially. Such differential regulation may have functional consequences for the effects of p53 on cell fate.
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Citations
Cites
p53 Mutations in Human Cancers
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Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death
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Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
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p53 is required for radiation-induced apoptosis in mouse thymocytes
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Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
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Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
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Definition of a consensus binding site for p53
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“Of central importance for growth arrest by p53 is transactivation of the waf1/p21 gene (7, 16).”
Backgroundp53-Dependent apoptosis suppresses tumor growth and progression in vivo
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Cited by
p53, the cellular gatekeeper for growth and division
Levine, A. J. (1997) · Cell · doi:10.1016/s0092-8674(00)81871-1 · Cited by 7,693
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Self-citationRajah, R., Valentinis, B., & Cohen, P. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.18.12181 · Cited by 722
ASPP Proteins Specifically Stimulate the Apoptotic Function of p53
Samuels-Lev, Y., O'Connor, D. J., Bergamaschi, D., Trigiante, G., Hsieh, J.-K., Zhong, S., Campargue, I., Naumovski, L., Crook, T., & Lu, X. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00367-7 · Cited by 664
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Metadata
- Authors
- Friedlander, P., Haupt, Y., Prives, C., & Oren, M.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1996-09-01
- Volume
- 16
- Issue
- 9
- Pages
- 4961-4971
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2151085515
- Cited by
- 278
- References
- 11
- FWCI
- 13.16
- Type
- journal article
- Language
- en
- Open access
- green
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- Friedlander, P., Haupt, Y., Prives, C., & Oren, M. (1996). A Mutant p53 That Discriminates between p53-Responsive Genes Cannot Induce Apoptosis. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.16.9.4961
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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