The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Isolation of an AP-1 Repressor by a Novel Method for Detecting Protein-Protein Interactions
Open accessAbstract
Transcription factor AP-1 transduces environmental signals to the transcriptional machinery. To ensure a quick response yet maintain tight control over AP-1 target genes, AP-1 activity is likely to be negatively regulated in nonstimulated cells. To identify proteins that interact with the Jun subunits of AP-1 and repress its activity, we developed a novel screen for detecting protein-protein interactions that is not based on a transcriptional readout. In this system, the mammalian guanyl nucleotide exchange factor (GEF) Sos is recruited to the Saccharomyces cerevisiae plasma membrane harboring a temperature-sensitive Ras GEF, Cdc25-2, allowing growth at the nonpermissive temperature. Using the Sos recruitment system, we identified new c-Jun-interacting proteins. One of these, JDP2, heterodimerizes with c-Jun in nonstimulated cells and represses AP-1-mediated activation.
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Cites
A novel genetic system to detect protein–protein interactions
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Cited by
Yu, X., Wu, L. C., Bowcock, A. M., Aronheim, A., & Baer, R. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.39.25388 · Cited by 389
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Rabring7, a Novel Rab7 Target Protein with a RING Finger Motif
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Metadata
- Authors
- Aronheim, A., Zandi, E., Hennemann, H., Elledge, S. J., & Karin, M.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1997-06-01
- Volume
- 17
- Issue
- 6
- Pages
- 3094-3102
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W1884315263
- Cited by
- 462
- References
- 45
- FWCI
- 6.41
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Aronheim, A., Zandi, E., Hennemann, H., Elledge, S. J., & Karin, M. (1997). Isolation of an AP-1 Repressor by a Novel Method for Detecting Protein-Protein Interactions. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.17.6.3094
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
