The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
The C-terminal (BRCT) Domains of BRCA1 Interact in Vivo with CtIP, a Protein Implicated in the CtBP Pathway of Transcriptional Repression
Open accessAbstract
The BRCA1 tumor suppressor encodes a polypeptide with two recognizable protein motifs: a RING domain near the N terminus and two tandem BRCT domains at the C terminus. Studies of tumor-associated mutations indicate that the RING and BRCT sequences are required for BRCA1-mediated tumor suppression. In addition, recent work has shown that BRCA1 is a potent regulator of RNA transcription and that the BRCT domains are also essential for this activity. Therefore, we used the Sos recruitment system to screen for proteins that bind this critical region of BRCA1. Our results show that the BRCT domains interact in vivo with CtIP, a protein originally identified on the basis of its association with the CtBP transcriptional co-repressor. This finding suggests that BRCA1 regulates gene expression, at least in part, by modulating CtBP-mediated transcriptional repression. Moreover, the in vivo interaction between BRCA1 and CtIP is completely ablated by each of three independent tumor-associated mutations affecting the BRCT motifs of BRCA1. These results indicate that the BRCA1-CtIP interaction may be required for tumor suppression by BRCA1.
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Cites
A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1
Miki, Y., Swensen, J., Shattuck-Eidens, D., Futreal, P. A., Harshman, K., Tavtigian, S., Liu, Q., Cochran, C., Bennett, L. M., Ding, W., et al. (1994) · Science · doi:10.1126/science.7545954 · Cited by 6,071
Association of BRCA1 with Rad51 in Mitotic and Meiotic Cells
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Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage
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Identification of a RING protein that can interact in vivo with the BRCA1 gene product
Wu, L. C., Wang, Z. W., Tsan, J. T., Spillman, M. A., Phung, A., Xu, X. L., Yang, M.-C. W., Hwang, L.-Y., Bowcock, A. M., & Baer, R. (1996) · Nature Genetics · doi:10.1038/ng1296-430 · Cited by 746
Self-citationFrom BRCA1 to RAP1: a widespread BRCT module closely associated with DNA repair
Callebaut, I., & Mornon, J.-P. (1997) · FEBS Letters · doi:10.1016/s0014-5793(96)01312-9 · Cited by 524
Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p21WAF1/CiPl
Somasundaram, K., Zhang, H., Zeng, Y.-X., Houvras, Y., Peng, Y., Zhang, H., Wu, G. S., Licht, J. D., Weber, B. L., & El-Deiry, W. S. (1997) · Nature · doi:10.1038/38291 · Cited by 509
BRCA1 physically associates with p53 and stimulates its transcriptional activity
Zhang, H., Somasundaram, K., Peng, Y., Tian, H., Zhang, H., Bi, D., Weber, B. L., & El-Deiry, W. S. (1998) · Oncogene · doi:10.1038/sj.onc.1201932 · Cited by 492
Isolation of an AP-1 Repressor by a Novel Method for Detecting Protein-Protein Interactions
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Cited by
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Bunting, S. F., Callén, E., Wong, N., Chen, H.-T., Polato, F., Gunn, A., Bothmer, A., Feldhahn, N., Fernandez-Capetillo, O., Cao, L., et al. (2010) · Cell · doi:10.1016/j.cell.2010.03.012 · Cited by 1,671
Human CtIP promotes DNA end resection
Sartori, A. A., Lukas, C., Coates, J., Mistrik, M., Fu, S., Bartek, J., Baer, R., Lukas, J., & Jackson, S. P. (2007) · Nature · doi:10.1038/nature06337 · Cited by 1,362
Self-citationHomologous Recombination and Human Health: The Roles of BRCA1, BRCA2, and Associated Proteins
Prakash, R., Zhang, Y., Feng, W., & Jasin, M. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016600 · Cited by 869
The control of DNA repair by the cell cycle
Hustedt, N., & Durocher, D. (2017) · Nature Cell Biology · doi:10.1038/ncb3452 · Cited by 738
Cantor, S. B., Bell, D. W., Ganesan, S., Kass, E. M., Drapkin, R., Grossman, S., Wahrer, D. C. R., Sgroi, D. C., Lane, W. S., Haber, D. A., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00304-x · Cited by 674
Metadata
- Authors
- Yu, X., Wu, L. C., Bowcock, A. M., Aronheim, A., & Baer, R.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1998-09
- Volume
- 273
- Issue
- 39
- Pages
- 25388-25392
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2164916497
- Cited by
- 389
- References
- 35
- FWCI
- 15.93
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Yu, X., Wu, L. C., Bowcock, A. M., Aronheim, A., & Baer, R. (1998). The C-terminal (BRCT) Domains of BRCA1 Interact in Vivo with CtIP, a Protein Implicated in the CtBP Pathway of Transcriptional Repression. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.273.39.25388
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