The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
Targeted Inactivation of Mouse RAD52 Reduces Homologous Recombination but Not Resistance to Ionizing Radiation
Open accessAbstract
The RAD52 epistasis group is required for recombinational repair of double-strand breaks (DSBs) and shows strong evolutionary conservation. In Saccharomyces cerevisiae, RAD52 is one of the key members in this pathway. Strains with mutations in this gene show strong hypersensitivity to DNA-damaging agents and defects in recombination. Inactivation of the mouse homologue of RAD52 in embryonic stem (ES) cells resulted in a reduced frequency of homologous recombination. Unlike the yeast Scrad52 mutant, MmRAD52(-/-) ES cells were not hypersensitive to agents that induce DSBs. MmRAD52 null mutant mice showed no abnormalities in viability, fertility, and the immune system. These results show that, as in S. cerevisiae, MmRAD52 is involved in recombination, although the repair of DNA damage is not affected upon inactivation, indicating that MmRAD52 may be involved in certain types of DSB repair processes and not in others. The effect of inactivating MmRAD52 suggests the presence of genes functionally related to MmRAD52, which can partly compensate for the absence of MmRad52 protein.
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Cites
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Targeted disruption of the Rad51 gene leads to lethality in embryonic mice.
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Rad51-deficient vertebrate cells accumulate chromosomal breaks prior to cell death
Sonoda, E. (1998) · The EMBO Journal · doi:10.1093/emboj/17.2.598 · Cited by 791
Lim, D.-S., & Hasty, P. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.12.7133 · Cited by 696
Human Rad51 Protein Promotes ATP-Dependent Homologous Pairing and Strand Transfer Reactions In Vitro
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Moore, J. K., & Haber, J. E. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.5.2164 · Cited by 623
Rad52 protein stimulates DNA strand exchange by Rad51 and replication protein A
New, J. H., Sugiyama, T., Zaitseva, E., & Kowalczykowski, S. C. (1998) · Nature · doi:10.1038/34950 · Cited by 588
Gene targeting: a practical approach.
Joyner, A. L. (1993) · Cited by 575
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Cited by
DNA double-strand breaks: signaling, repair and the cancer connection
Khanna, K. K., & Jackson, S. P. (2001) · Nature Genetics · doi:10.1038/85798 · Cited by 2,455
Multiple Pathways of Recombination Induced by Double-Strand Breaks in Saccharomyces cerevisiae
Pâques, F., & Haber, J. E. (1999) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.63.2.349-404.1999 · Cited by 2,120
XRCC3 promotes homology-directed repair of DNA damage in mammalian cells
Pierce, A. J., Johnson, R. D., Thompson, L. H., & Jasin, M. (1999) · Genes & Development · doi:10.1101/gad.13.20.2633 · Cited by 1,379
Takata, M., Sasaki, M. S., Sonoda, E., Morrison, C., Hashimoto, M., Utsumi, H., Yamaguchi‐Iwai, Y., Shinohara, A., & Takeda, S. (1998) · The EMBO Journal · doi:10.1093/emboj/17.18.5497 · Cited by 1,229
Chromosomal stability and the DNA double-stranded break connection
van Gent, D. C., Hoeijmakers, J. H. J., & Kanaar, R. (2001) · Nature Reviews Genetics · doi:10.1038/35056049 · Cited by 1,219
Metadata
- Authors
- Rijkers, T., Van Den Ouweland, J., Morolli, B., Rolink, A. G., Baarends, W. M., Van Sloun, P. P. H., Lohman, P. H. M., & Pastink, A.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1998-11-01
- Volume
- 18
- Issue
- 11
- Pages
- 6423-6429
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2117848425
- Cited by
- 329
- References
- 58
- FWCI
- 7.54
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Rijkers, T., Van Den Ouweland, J., Morolli, B., Rolink, A. G., Baarends, W. M., Van Sloun, P. P. H., Lohman, P. H. M., & Pastink, A. (1998). Targeted Inactivation of Mouse RAD52 Reduces Homologous Recombination but Not Resistance to Ionizing Radiation. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.18.11.6423
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
