Eukaryotic Translation Initiation Factor 4G Is Targeted for Proteolytic Cleavage by Caspase 3 during Inhibition of Translation in Apoptotic Cells

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

Liu, X., Kim, C. N., Yang, J., Jemmerson, R., & Wang, X. (1996) · Cell · doi:10.1016/s0092-8674(00)80085-9 · Cited by 5,167 · see citing works

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

Yang, J., Liu, X., Bhalla, K. N., Kim, C. N., Ibrado, A. M., Cai, J., Peng, T.-I., Jones, D. P., & Wang, X. (1997) · Science · doi:10.1126/science.275.5303.1129 · Cited by 4,913 · see citing works

Caspases: the executioners of apoptosis

Cohen, G. M. (1997) · Biochemical Journal · doi:10.1042/bj3260001 · Cited by 4,720 · see citing works

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

Kluck, R. M., Bossy‐Wetzel, E., Green, D. R., & Newmeyer, D. D. (1997) · Science · doi:10.1126/science.275.5303.1132 · Cited by 4,715 · see citing works

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

Nicholson, D. W., Ali, A., Thornberry, N. A., Vaillancourt, J. P., Ding, C. K., Gallant, M., Gareau, Y., Griffin, P. R., Labelle, M., Lazebnik, Y. A., et al. (1995) · Nature · doi:10.1038/376037a0 · Cited by 3,980 · see citing works

Human ICE/CED-3 Protease Nomenclature

Alnemri, E. S., Livingston, D. J., Nicholson, D. W., Salvesen, G. S., Thornberry, N. A., Wong, W. W., & Yuan, J. (1996) · Cell · doi:10.1016/s0092-8674(00)81334-3 · Cited by 2,371 · see citing works

Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

Tewari, M., Quan, L. T., O’Rourke, K. M., Desnoyers, S., Zeng, Z., Beidler, D. R., Poirier, G. G., Salvesen, G. S., & Dixit, V. M. (1995) · Cell · doi:10.1016/0092-8674(95)90541-3 · Cited by 2,367 · see citing works

The Translation Initiation Factor eIF-4E Binds to a Common Motif Shared by the Translation Factor eIF-4γ and the Translational Repressors 4E-Binding Proteins

Mader, S., Lee, H. B., Pause, A., & Sonenberg, N. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.9.4990 · Cited by 685 · see citing works

Inhibition of HeLa cell protein synthesis following poliovirus infection correlates with the proteolysis of a 220,000-dalton polypeptide associated with eucaryotic initiation factor 3 and a cap binding protein complex.

Etchison, D., Milburn, S. C., Edery, I., Sonenberg, N., & Hershey, J. W. B. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)33352-0 · Cited by 583 · see citing works

Mapping of Functional Domains in Eukaryotic Protein Synthesis Initiation Factor 4G (eIF4G) with Picornaviral Proteases

Lamphear, B. J., Kirchweger, R., Skern, T., & Rhoads, R. E. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.37.21975 · Cited by 557 · see citing works

Induction of apoptosis (programmed cell death) in human leukemic HL-60 cells by inhibition of RNA or protein synthesis.

Martin, S. J., LENNON, S. V., BONHAM, Á. M., & Cotter, T. G. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.145.6.1859 · Cited by 483 · see citing works

Analysis of Events Associated With Cell Cycle Arrest at G2 Phase and Cell Death Induced by Cisplatin

Sorenson, C. M., Barry, M. A., & Eastman, A. R. (1990) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/82.9.749 · Cited by 440 · see citing works

New initiation factor activity required for globin mRNA translation.

GRIFO, J. A., Tahara, S. M., Morgan, M. A., Shatkin, A. J., & Merrick, W. C. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)81965-6 · Cited by 406 · see citing works

Potassium Deprivation-Induced Apoptosis of Cerebellar Granule Neurons: A Sequential Requirement for New mRNA and Protein Synthesis, ICE-Like Protease Activity, and Reactive Oxygen Species

Schulz, J. B., Weller, M., & Klockgether, T. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-15-04696.1996 · Cited by 322 · see citing works

A Novel Functional Human Eukaryotic Translation Initiation Factor 4G

Gradi, A., Imataka, H., Svitkin, Y. V., Rom, E., Raught, B., Morino, S., & Sonenberg, N. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.1.334 · Cited by 296 · see citing works

Mapping the cleavage site in protein synthesis initiation factor eIF-4 gamma of the 2A proteases from human Coxsackievirus and rhinovirus.

Lamphear, B. J., Yan, R., Yang, F., Waters, D. A., Liebig, H., Klump, H., Kuechler, E., Skern, T., & Rhoads, R. E. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)36499-3 · Cited by 270 · see citing works

RNA-protein interactions in regulation of picornavirus RNA translation

Belsham, G. J., & Sonenberg, N. (1996) · Microbiological Reviews · doi:10.1128/mr.60.3.499-511.1996 · Cited by 266 · see citing works

Activation of interleukin‐ 1β by a co‐induced protease

Black, R. A., Kronheim, S. R., & Sleath, P. R. (1989) · FEBS Letters · doi:10.1016/0014-5793(89)81376-6 · Cited by 262 · see citing works

Activation of Multiple Interleukin-1β Converting Enzyme Homologues in Cytosol and Nuclei of HL-60 Cells during Etoposide-induced Apoptosis

Martins, L. M., Kottke, T. J., Mesner, P. W., Basi, G. S., Sinha, S., Frigon, N. L., Tatar, E. L., Tung, J. S., Bryant, K., Takahashi, A., et al. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.11.7421 · Cited by 203 · see citing works

eIF4G: translation's mystery factor begins to yield its secrets.

Morley, S., Curtis, P. S., & Pain, V. M. (1997) · PubMed · Cited by 163 · see citing works

Amino acid sequence of the human protein synthesis initiation factor eIF-4 gamma

Yan, R., Rychlik, W., Etchison, D., & Rhoads, R. E. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)50080-6 · Cited by 140 · see citing works

Retinoid-Induced Apoptosis and Sp1 Cleavage Occur Independently of Transcription and Require Caspase Activation

Piedrafita, F. J., & Pfahl, M. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.11.6348 · Cited by 135 · see citing works

Importance of the redox state of cytochrome c during caspase activation in cytosolic extracts

Hampton, M. B., Zhivotovsky, B., SLATER, F. G. A., BURGESS, H. D., & Orrenius, S. (1998) · Biochemical Journal · doi:10.1042/bj3290095 · Cited by 119 · see citing works

Cap binding protein complex that restores protein synthesis in heat-shocked Ehrlich cell lysates contains highly phosphorylated eIF-4E.

Lamphear, B. J., & Panniers, R. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)39358-5 · Cited by 109 · see citing works

Demonstration in vitro that eucaryotic initiation factor 3 is active but that a cap-binding protein complex is inactive in poliovirus-infected HeLa cells

Etchison, D., Hansen, J. L., Ehrenfeld, E., Edery, I., Sonenberg, N., Milburn, S. C., & Hershey, J. W. B. (1984) · Journal of Virology · doi:10.1128/jvi.51.3.832-837.1984 · Cited by 85 · see citing works

Human rhinovirus 14 infection of HeLa cells results in the proteolytic cleavage of the p220 cap-binding complex subunit and inactivates globin mRNA translation in vitro

Etchison, D. O., & Fout, S. (1985) · Journal of Virology · doi:10.1128/jvi.54.2.634-638.1985 · Cited by 76 · see citing works

Reevaluation of the Role of de Novo Protein Synthesis in Rat Thymocyte Apoptosis

Chow, S. C., Peters, I., & Orrenius, S. (1995) · Experimental Cell Research · doi:10.1006/excr.1995.1019 · Cited by 75 · see citing works

Isolation and structural characterization of cap-binding proteins from poliovirus-infected HeLa cells

Lee, K. A., Edery, I., & Sonenberg, N. (1985) · Journal of Virology · doi:10.1128/jvi.54.2.515-524.1985 · Cited by 65 · see citing works

Restriction of translation of capped mRNA in vitro as a model for poliovirus-induced inhibition of host cell protein synthesis: relationship to p220 cleavage

Lloyd, R. E., Jense, H. G., & Ehrenfeld, E. (1987) · Journal of Virology · doi:10.1128/jvi.61.8.2480-2488.1987 · Cited by 57 · see citing works

Relationship of eukaryotic initiation factor 3 to poliovirus-induced p220 cleavage activity

Wyckoff, E. E., Lloyd, R. E., & Ehrenfeld, E. (1992) · Journal of Virology · doi:10.1128/jvi.66.5.2943-2951.1992 · Cited by 57 · see citing works

Foot-and-mouth disease virion RNA: Studies on the relation between the length of its 3′-poly(A) segment and infectivity

Grubman, M. J., Baxt, B., & Bachrach, H. L. (1979) · Virology · doi:10.1016/0042-6822(79)90369-6 · Cited by 54 · see citing works

Activation of the Na(+)/H(+) antiporter, Na+/HCO3(-)/CO3(2-) cotransporter, or Cl(-)/HCO3(-) exchanger in spontaneous thymocyte apoptosis

Tsao, N., & Lei, H. Y. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.157.3.1107 · Cited by 49 · see citing works

Direct Cleavage of eIF4G by Poliovirus 2A Protease Is Inefficientin Vitro

Bovée, M., Lamphear, B. J., Rhoads, R. E., & Lloyd, R. E. (1998) · Virology · doi:10.1006/viro.1998.9172 · Cited by 48 · see citing works

In vitro synthesis of human protein synthesis initiation factor 4 gamma and its localization on 43 and 48 S initiation complexes.

Joshi, B., Yan, R., & Rhoads, R. E. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42133-8 · Cited by 46 · see citing works

Translation of foot-and-mouth disease virion RNA and processing of the primary cleavage products in a rabbit reticulocyte lysate

Grubman, M. J., & Baxt, B. (1982) · Virology · doi:10.1016/0042-6822(82)90399-3 · Cited by 40 · see citing works

Restrictin-P/Stromal Activin A, Kills its Target Cells Via an Apoptotic Mechanism

Sternberg, D., Honigwachs‐Sha'Anani, J., Brosh, N., Malik, Z., Burstein, Y., & Zipori, D. (1995) · Growth Factors · doi:10.3109/08977199509028966 · Cited by 32 · see citing works

Initiation factor preparations from poliovirus-infected cells restrict translation in reticulocyte lysates

Brown, B. A., & Ehrenfeld, E. (1980) · Virology · doi:10.1016/0042-6822(80)90191-9 · Cited by 31 · see citing works

Variations in cap-binding complexes from uninfected and poliovirus-infected HeLa cells.

Etchison, D. O., & Smith, K. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)39140-9 · Cited by 24 · see citing works

The outcome of poliovirus infections in K562 cells is cytolytic rather than persistent after hemin-induced differentiation

Benton, P. A., Barrett, D. J., Matts, R. L., & Lloyd, R. E. (1996) · Journal of Virology · doi:10.1128/jvi.70.8.5525-5532.1996 · Cited by 21 · see citing works

Effects of Poliovirus 2Apro on Vaccinia Virus Gene Expression

Feduchi, E., Aldabe, R., Novoa, I., & Carrasco, L. (1995) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1995.849_a.x · Cited by 20 · see citing works

K562 Cell Strains Differ in Their Response to Poliovirus Infection

Benton, P. A., Murphy, J. W., & Lloyd, R. E. (1995) · Virology · doi:10.1006/viro.1995.1541 · Cited by 15 · see citing works

The Translational Inhibitor Cycloheximide Represses Growth Factor Depletion–Induced Apoptosis in An Alb–Sv40t Transgenic Rat Liver Cell Line

Bulera, S. J., Sattler, C. A., & Pitot, H. C. (1996) · Hepatology · doi:10.1002/hep.510230641 · Cited by 8 · see citing works

ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility

Zheng, G., Dahl, J. A., Niu, Y., Fedorcsak, P., Huang, C.-M., Li, C. J., Vågbø, C. B., Shi, Y., Wang, W.-L., Song, S.-H., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2012.10.015 · Cited by 3,550 · see citing works

eIF4 Initiation Factors: Effectors of mRNA Recruitment to Ribosomes and Regulators of Translation

Gingras, A., Raught, B., & Sonenberg, N. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.913 · Cited by 2,103 · see citing works

Many cuts to ruin: a comprehensive update of caspase substrates

Fischer, U., Jänicke, R. U., & Schulze‐Osthoff, K. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401160 · Cited by 1,025 · see citing works

Internal ribosome entry sites in eukaryotic mRNA moleculesPreprint

Hellen, C. U. T., & Sarnow, P. (2001) · Genes & Development · doi:10.1101/gad.891101 · Cited by 977 · see citing works

Apoptotic Pathway and MAPKs Differentially Regulate Chemotropic Responses of Retinal Growth Cones

Campbell, D. S., & Holt, C. E. (2003) · Neuron · doi:10.1016/s0896-6273(03)00158-2 · Cited by 303 · see citing works

Re‐programming of translation following cell stress allows IRES‐mediated translation to predominate

Spriggs, K. A., Stoneley, M., Bushell, M., & Willis, A. E. (2007) · Biology of the Cell · doi:10.1042/bc20070098 · Cited by 317 · see citing works

Apoptosis and brain ischaemia

Love, S. (2003) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(03)00022-8 · Cited by 290 · see citing works

African Swine Fever Virus Biology and Vaccine Approaches

Revilla, Y., Pérez-Núñez, D., & Richt, J. A. (2017) · Advances in virus research · doi:10.1016/bs.aivir.2017.10.002 · Cited by 238 · see citing works

Molecular Pathways of Protein Synthesis Inhibition during Brain Reperfusion: Implications for Neuronal Survival or Death

DeGracia, D. J., Kumar, R., Owen, C. R., Krause, G. S., & White, B. C. (2002) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200202000-00001 · Cited by 233 · see citing works

Translation initiation factor modifications and the regulation of protein synthesis in apoptotic cells

Clemens, M. J., Bushell, M., Jeffrey, I. W., Pain, V. M., & Morley, S. (2000) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400695 · Cited by 228 · see citing works

Enterovirus 2A pro Targets MDA5 and MAVS in Infected Cells

Feng, Q., Langereis, M. A., Lork, M., Nguyen, M. T., Hato, S. V., Lanke, K. H. W., Emdad, L., Bhoopathi, P., Fisher, P. B., Lloyd, R. E., et al. (2014) · Journal of Virology · doi:10.1128/jvi.02712-13 · Cited by 223 · see citing works

Conducting the initiation of protein synthesis: the role of eIF4G

Prévôt, D., Darlix, J., & Ohlmann, T. (2003) · Biology of the Cell · doi:10.1016/s0248-4900(03)00031-5 · Cited by 221 · see citing works

Heterogeneity and specialized functions of translation machinery: from genes to organisms

Genuth, N. R., & Barna, M. (2018) · Nature Reviews Genetics · doi:10.1038/s41576-018-0008-z · Cited by 235 · see citing works

c-Myc Protein Synthesis Is Initiated from the Internal Ribosome Entry Segment during Apoptosis

Stoneley, M., Chappell, S. A., Jopling, C. L., Dickens, M., MacFarlane, M., & Willis, A. E. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.4.1162-1169.2000 · Cited by 219 · see citing works

Initiation Factor eIF2α Phosphorylation in Stress Responses and Apoptosis

Clemens, M. J. (2001) · Progress in molecular and subcellular biology · doi:10.1007/978-3-662-09889-9_3 · Cited by 216 · see citing works

Initiation of Apaf-1 translation by internal ribosome entry

Coldwell, M. J., Mitchell, S. A., Stoneley, M., MacFarlane, M., & Willis, A. E. (2000) · Oncogene · doi:10.1038/sj.onc.1203407 · Cited by 199 · see citing works

Chaperone Hsp27 inhibits translation during heat shock by binding eIF4G and facilitating dissociation of cap-initiation complexesPreprint

Cuesta, R., Laroia, G., & Schneider, R. J. (2000) · Genes & Development · doi:10.1101/gad.14.12.1460 · Cited by 197 · see citing works

Physical Association of Eukaryotic Initiation Factor 4G (eIF4G) with eIF4A Strongly Enhances Binding of eIF4G to the Internal Ribosomal Entry Site of Encephalomyocarditis Virus and Is Required for Internal Initiation of Translation

Lomakin, I. B., Hellen, C. U. T., & Pestova, T. V. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.16.6019-6029.2000 · Cited by 194 · see citing works

Identification and characterization of the human ARD1–NATH protein acetyltransferase complex

Arnesen, T., ANDERSON, D., BALDERSHEIM, C., Lanotte, M., Varhaug, J. E., & Lillehaug, J. R. (2005) · Biochemical Journal · doi:10.1042/bj20041071 · Cited by 191 · see citing works

eIF4GI links nutrient sensing by mTOR to cell proliferation and inhibition of autophagy

Ramírez‐Valle, F., Braunstein, S. E., Zavadil, J., Formenti, S. C., & Schneider, R. J. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200710215 · Cited by 191 · see citing works

A Novel Form of DAP5 Protein Accumulates in Apoptotic Cells as a Result of Caspase Cleavage and Internal Ribosome Entry Site-Mediated Translation

Henis‐Korenblit, S., Levy-Strumpf, N., Goldstaub, D., & Kimchi, A. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.2.496-506.2000 · Cited by 183 · see citing works

Translation Inhibition in Apoptosis

Saelens, X., Kalai, M., & Vandenabeele, P. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103674200 · Cited by 177 · see citing works

Tissue-Specific Bcl-2 Protein Partners in Apoptosis: An Ovarian Paradigm

Hsu, S. Y., & Hsueh, A. J. W. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.2.593 · Cited by 173 · see citing works

Cell Death, Damage-Associated Molecular Patterns, and Sterile Inflammation in Cardiovascular Disease

Zheng, Y., Gardner, S. E., & Clarke, M. C. H. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.224907 · Cited by 172 · see citing works

Translation initiation: adept at adapting

Dever, T. E. (1999) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(99)01457-7 · Cited by 163 · see citing works

La Autoantigen Is Necessary for Optimal Function of the Poliovirus and Hepatitis C Virus Internal Ribosome Entry Site In Vivo and In Vitro

Costa‐Mattioli, M., Svitkin, Y. V., & Sonenberg, N. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.15.6861-6870.2004 · Cited by 159 · see citing works

Human Cytomegalovirus Infection Induces Rapamycin-Insensitive Phosphorylation of Downstream Effectors of mTOR Kinase

Kudchodkar, S. B., Yu, Y., Maguire, T. G., & Alwine, J. C. (2004) · Journal of Virology · doi:10.1128/jvi.78.20.11030-11039.2004 · Cited by 157 · see citing works

Protein Factor Requirements of the Apaf-1 Internal Ribosome Entry Segment: Roles of Polypyrimidine Tract Binding Protein and upstream of N-ras

Mitchell, S. A., Brown, E. C., Coldwell, M. J., Jackson, R. J., & Willis, A. E. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.10.3364-3374.2001 · Cited by 153 · see citing works

Eukaryotic Translation Initiation Factor 4AIII (eIF4AIII) Is Functionally Distinct from eIF4AI and eIF4AII

Li, Q., Imataka, H., Morino, S., Rogers, G. W., Richter-Cook, N. J., Merrick, W. C., & Sonenberg, N. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.11.7336 · Cited by 151 · see citing works

Distinct Regulation of Internal Ribosome Entry Site-mediated Translation following Cellular Stress Is Mediated by Apoptotic Fragments of eIF4G Translation Initiation Factor Family Members eIF4GI and p97/DAP5/NAT1

Nevins, T. A., Harder, Z., Korneluk, R. G., & Holčı́k, M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m206781200 · Cited by 146 · see citing works

Caspase Cleavage of Initiation Factor 4E-Binding Protein 1 Yields a Dominant Inhibitor of Cap-Dependent Translation and Reveals a Novel Regulatory Motif

Tee, A. R., & Proud, C. G. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.6.1674-1683.2002 · Cited by 139 · see citing works

Poly(A)-binding protein interaction with elF4G stimulates picornavirus IRES-dependent translation.

Svitkin, Y. V., Imataka, H., Khaleghpour, K., Kahvejian, A., Liebig, H., & Sonenberg, N. (2001) · Europe PMC (PubMed Central) · Cited by 138 · see citing works

Infection with enterovirus 71 or expression of its 2A protease induces apoptotic cell death

Kuo, R., Kung, S., Hsu, Y., & Liu, W. (2002) · Journal of General Virology · doi:10.1099/0022-1317-83-6-1367 · Cited by 135 · see citing works

Efficient Cleavage of Ribosome-Associated Poly(A)-Binding Protein by Enterovirus 3C Protease

Kuyumcu-Martinez, N. M., Joachims, M. L., & Lloyd, R. E. (2002) · Journal of Virology · doi:10.1128/jvi.76.5.2062-2074.2002 · Cited by 135 · see citing works

Poliovirus Protease 3Cpro Kills Cells by Apoptosis

Barco, Á., Feduchi, E., & Carrasco, L. (2000) · Virology · doi:10.1006/viro.1999.0043 · Cited by 133 · see citing works

The EMAPII Cytokine Is Released from the Mammalian Multisynthetase Complex after Cleavage of Its p43/proEMAPII Component

Shalak, V. F., Kaminska, M., Mitnacht‐Kraus, R., Vandenabeele, P., Clauss, M. A., & Mirande, M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100489200 · Cited by 132 · see citing works

HIV-1 protease cleaves eukaryotic initiation factor 4G and inhibits cap-dependent translation

Ventoso, I., Blanco, R., Perales, C., & Carrasco, L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.231343498 · Cited by 130 · see citing works

Translational control by viral proteinases

Lloyd, R. E. (2005) · Virus Research · doi:10.1016/j.virusres.2005.10.016 · Cited by 129 · see citing works

Selenite targets eIF4E-binding protein-1 to inhibit translation initiation and induce the assembly of non-canonical stress granules

Fujimura, K., Sasaki, A. T., & Anderson, P. J. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks566 · Cited by 127 · see citing works

Poliovirus 2A Protease Induces Apoptotic Cell Death

Goldstaub, D., Gradi, A., Bercovitch, Z., Grosman, Z., Nophar, Y., Luria, S., Sonenberg, N., & Kahana, C. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.4.1271-1277.2000 · Cited by 122 · see citing works

Regulation of translation initiation following stress

Sheikh, M. S., & Fornace, A. J. (1999) · Oncogene · doi:10.1038/sj.onc.1203131 · Cited by 120 · see citing works

The j-Subunit of Human Translation Initiation Factor eIF3 Is Required for the Stable Binding of eIF3 and Its Subcomplexes to 40 S Ribosomal Subunits in Vitro

Fraser, C. S., Lee, J. Y., Mayeur, G. L., Bushell, M., Doudna, J. A., & Hershey, J. W. B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312745200 · Cited by 117 · see citing works

DNA-damaging agents cause inactivation of translational regulators linked to mTOR signalling

Tee, A. R., & Proud, C. G. (2000) · Oncogene · doi:10.1038/sj.onc.1203622 · Cited by 119 · see citing works

Subcellular Relocalization of a Trans -acting Factor Regulates XIAP IRES-dependent Translation

Lewis, S. M., Veyrier, A., Ungureanu, N. H., Bonnal, S., Vagner, S., & Holčı́k, M. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-06-0515 · Cited by 116 · see citing works

Poliovirus-Mediated Disruption of Cytoplasmic Processing Bodies

Dougherty, J. D., White, J. P., & Lloyd, R. E. (2010) · Journal of Virology · doi:10.1128/jvi.01657-10 · Cited by 113 · see citing works

Regulation of Gene Expression by Internal Ribosome Entry Sites or Cryptic Promoters: the eIF4G Story

Han, B., & Zhang, J. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.21.7372-7384.2002 · Cited by 113 · see citing works

Translational Control of the Antiapoptotic Function of Ras

Polunovsky, V. A., Gingras, A., Sonenberg, N., Peterson, M., Tan, A., Rubins, J. B., Manivel, J. C., & Bitterman, P. B. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001938200 · Cited by 111 · see citing works

The 5′ and 3′ ends of alphavirus RNAs – Non-coding is not non-functional

Hyde, J., Chen, R., Trobaugh, D. W., Diamond, M., Weaver, S. C., Klimstra, W. B., & Wilusz, J. (2015) · Virus Research · doi:10.1016/j.virusres.2015.01.016 · Cited by 105 · see citing works

Elongation factor-1 alpha is a selective regulator of growth factor withdrawal and ER stress-induced apoptosis

Talapatra, S., Wagner, J. D. O., & Thompson, C. B. (2002) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401078 · Cited by 105 · see citing works

eIF4G has intrinsic G-quadruplex binding activity that is required for tiRNA function

Lyons, S. M., Kharel, P., Akiyama, Y., Ojha, S., Dave, D., Цветков, В. Б., Merrick, W. C., Ivanov, P. V., & Anderson, P. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa336 · Cited by 103 · see citing works

The virology and developments toward control of human enterovirus 71

Yi, L., Lu, J., Kung, H., & He, M. (2011) · Critical Reviews in Microbiology · doi:10.3109/1040841x.2011.580723 · Cited by 103 · see citing works

Disruption of the Interaction of Mammalian Protein Synthesis Eukaryotic Initiation Factor 4B with the Poly(A)-binding Protein by Caspase- and Viral Protease-mediated Cleavages

Bushell, M., Wood, W., Carpenter, G., Pain, V. M., Morley, S., & Clemens, M. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100384200 · Cited by 102 · see citing works

Internal Ribosome Entry Site Regulates Translation of Kaposi's Sarcoma-Associated Herpesvirus FLICE Inhibitory Protein

Low, W., Harries, M., Ye, H., Du, M., Boshoff, C., & Collins, M. K. (2001) · Journal of Virology · doi:10.1128/jvi.75.6.2938-2945.2001 · Cited by 102 · see citing works

Viroporins from RNA viruses induce caspase-dependent apoptosis

Madan, V., Castelló, A., & Carrasco, L. (2007) · Cellular Microbiology · doi:10.1111/j.1462-5822.2007.01057.x · Cited by 101 · see citing works

Eukaryotic translation initiation factor 4GI and p97 promote cellular internal ribosome entry sequence-driven translation

Hundsdoerfer, P., Thoma, C., & Hentze, M. W. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506536102 · Cited by 100 · see citing works

Translational regulation in cell stress and apoptosis. Roles of the eIF4E binding proteins

Clemens, M. J. (2001) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2001.tb00157.x · Cited by 98 · see citing works

Interferons and Apoptosis

Clemens, M. J. (2003) · Journal of Interferon & Cytokine Research · doi:10.1089/107999003766628124 · Cited by 96 · see citing works

Enhancement of IRES-Mediated Translation of the c-myc and BiP mRNAs by the Poly(A) Tail Is Independent of Intact eIF4G and PABP

Thoma, C., Bergamini, G., Galy, B., Hundsdoerfer, P., & Hentze, M. W. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.08.021 · Cited by 95 · see citing works

L13a Blocks 48S Assembly: Role of a General Initiation Factor in mRNA-Specific Translational Control

Kapasi, P., Chaudhuri, S., Vyas, K., Baus, D., Komar, A. A., Fox, P. L., Merrick, W. C., & Mazumder, B. (2007) · Molecular Cell · doi:10.1016/j.molcel.2006.11.028 · Cited by 94 · see citing works

Initiation factor modifications in the preapoptotic phase

Morley, S., Coldwell, M. J., & Clemens, M. J. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401591 · Cited by 94 · see citing works

The p34 -related Cyclin-dependent kinase 11 Interacts with the p47 Subunit of Eukaryotic Initiation Factor 3 during Apoptosis

Shi, J., Feng, Y., Goulet, A., Vaillancourt, R. R., Sachs, N. A., Hershey, J. W. B., & Nelson, M. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m206427200 · Cited by 90 · see citing works

Changes in integrity and association of eukaryotic protein synthesis initiation factors during apoptosis

Bushell, M., Wood, W., Clemens, M. J., & Morley, S. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2000.01101.x · Cited by 87 · see citing works

Cleavage of polypeptide chain initiation factor eIF4GI during apoptosis in lymphoma cells: characterisation of an internal fragment generated by caspase-3-mediated cleavage

Bushell, M., Poncet, D., Marissen, W. E., Flotow, H., Lloyd, R. E., Clemens, M., & Morley, S. (2000) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400699 · Cited by 87 · see citing works

Generation of Multiple Isoforms of Eukaryotic Translation Initiation Factor 4GI by Use of Alternate Translation Initiation Codons

Byrd, M. P., Zamora, M., & Lloyd, R. E. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.13.4499-4511.2002 · Cited by 87 · see citing works

Post-transcriptional and post-translational regulation of Bcl2

Willimott, S., & Wagner, S. D. (2010) · Biochemical Society Transactions · doi:10.1042/bst0381571 · Cited by 92 · see citing works

African swine fever virus controls the host transcription and cellular machinery of protein synthesis

Sánchez, E. G., Quintas, A., Nogal, M., Castelló, A., & Revilla, Y. (2012) · Virus Research · doi:10.1016/j.virusres.2012.10.025 · Cited by 89 · see citing works

Regulation of Host Translational Machinery by African Swine Fever Virus

Castelló, A., Quintas, A., Sánchez, E. G., Sabina, P., Nogal, M., Carrasco, L., & Revilla, Y. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000562 · Cited by 83 · see citing works

Individual expression of poliovirus 2Apro and 3Cpro induces activation of caspase-3 and PARP cleavage in HeLa cells

Calandria, C., Irurzun, A., Barco, Á., & Carrasco, L. (2004) · Virus Research · doi:10.1016/j.virusres.2004.02.042 · Cited by 83 · see citing works

Phosphorylation of eIF2α in response to 26S proteasome inhibition is mediated by the haem-regulated inhibitor (HRI) kinase

Yerlikaya, A., Kimball, S. R., & Stanley, B. A. (2008) · Biochemical Journal · doi:10.1042/bj20080324 · Cited by 81 · see citing works

Identification of Caspase 3-mediated Cleavage and Functional Alteration of Eukaryotic Initiation Factor 2α in Apoptosis

Marissen, W. E., Guo, Y., Thomas, A. A. M., Matts, R. L., & Lloyd, R. E. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.13.9314 · Cited by 77 · see citing works

The Multifaceted Poliovirus 2A Protease: Regulation of Gene Expression by Picornavirus Proteases

Castelló, A., Álvarez, E. A., & Carrasco, L. (2011) · BioMed Research International · doi:10.1155/2011/369648 · Cited by 76 · see citing works

Cleavage of eukaryotic translation initiation factor 4GII correlates with translation inhibition during apoptosis

Marissen, W. E., Gradi, A., Sonenberg, N., & Lloyd, R. E. (2000) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400750 · Cited by 73 · see citing works

Enterovirus Persistence in Cardiac Cells of Patients With Idiopathic Dilated Cardiomyopathy Is Linked to 5’ Terminal Genomic RNA-Deleted Viral Populations With Viral-Encoded Proteinase Activities

Bouin, A., Gretteau, P.-A., Wehbe, M., Renois, F., N’Guyen, Y., Lévêque, N., Vu, M. N., Tracy, S., Chapman, N. M., Bruneval, P., et al. (2019) · Circulation · doi:10.1161/circulationaha.118.035966 · Cited by 73 · see citing works

Caspase‐3 is necessary and sufficient for cleavage of protein synthesis eukaryotic initiation factor 4G during apoptosis

Bushell, M., McKendrick, L., Jänicke, R. U., Clemens, M. J., & Morley, S. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)00614-6 · Cited by 72 · see citing works

A Continuous-Exchange Cell-Free Protein Synthesis System Based on Extracts from Cultured Insect Cells

Stech, M., Quast, R. B., Sachse, R., Schulze, C., Wüstenhagen, D. A., & Kubick, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0096635 · Cited by 70 · see citing works

Translation of cellular inhibitor of apoptosis protein 1 (c-IAP1) mRNA is IRES mediated and regulated during cell stress

Eden, M. E. V., Byrd, M. P., Sherrill, K. W., & Lloyd, R. E. (2004) · RNA · doi:10.1261/rna.5156804 · Cited by 70 · see citing works

Translation of Eukaryotic Translation Initiation Factor 4GI (eIF4GI) Proceeds from Multiple mRNAs Containing a Novel Cap-dependent Internal Ribosome Entry Site (IRES) That Is Active during Poliovirus Infection

Byrd, M. P., Zamora, M., & Lloyd, R. E. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414014200 · Cited by 69 · see citing works

Mechanism of Protection from Light-Induced Retinal Degeneration by the Synthetic Antioxidant Phenyl- N-tert -Butylnitrone

Tomita, H., Kotake, Y., & Anderson, R. E. (2005) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.04-0946 · Cited by 67 · see citing works

Foot-and-mouth disease virus infection induces proteolytic cleavage of PTB, eIF3a,b, and PABP RNA-binding proteins

Rodríguez‐Pulido, M., Serrano, P., Sáiz, M., & Martı́nez-Salas, E. (2007) · Virology · doi:10.1016/j.virol.2007.03.013 · Cited by 65 · see citing works

Post-Transcriptional Regulation of the Androgen Receptor by Mammalian Target of Rapamycin

Cinar, B., Benedetti, A. D., & Freeman, M. R. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3411 · Cited by 65 · see citing works

Caspase-mediated cleavage of eukaryotic translation initiation factor subunit 2α

Satoh, S., Hijikata, M., Handa, H., & Shimotohno, K. (1999) · Biochemical Journal · doi:10.1042/bj3420065 · Cited by 62 · see citing works

Hepatitis B virus mutations associated with fulminant hepatitis induce apoptosis in primary Tupaia hepatocytes†

Baumert, T. F., Chun, Y., Schürmann, P., Köck, J., Ziegler, C., Grüllich, C., Nassal, M., Liang, T. J., Blum, H. E., & von Weizsäcker, F. (2005) · Hepatology · doi:10.1002/hep.20553 · Cited by 61 · see citing works

Cleavage of eukaryotic initiation factor eIF4G and inhibition of host-cell protein synthesis during feline calicivirus infection

Willcocks, M. M., Carter, M. J., & Roberts, L. O. (2004) · Journal of General Virology · doi:10.1099/vir.0.19564-0 · Cited by 61 · see citing works

Overexpression of Interferon-γ-inducible GTPase Inhibits Coxsackievirus B3-induced Apoptosis through the Activation of the Phosphatidylinositol 3-Kinase/Akt Pathway and Inhibition of Viral Replication

Zhang, H. M., Ji, Y., Cheung, P., Luo, H., Yanagawa, B., Chau, D., Stephan-Tozy, N., Wong, B. W., Zhang, J., Wilson, J. E., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305352200 · Cited by 61 · see citing works

Retinal axon guidance: novel mechanisms for steering

van Horck, F. P. G., Weinl, C., & Holt, C. E. (2004) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2004.01.002 · Cited by 60 · see citing works

mRNA translation is compartmentalized to the endoplasmic reticulum following physiological inhibition of cap-dependent translation

Lerner, R. S., & Nicchitta, C. V. (2006) · RNA · doi:10.1261/rna.2318906 · Cited by 59 · see citing works

Impaired translational response and increased protein kinase PKR expression in T cells from lupus patients

Grolleau‐Julius, A., Kaplan, M. J., Hanash, S., Beretta, L., & Richardson, B. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9352 · Cited by 54 · see citing works

Mitochondrial DNA in cell death and inflammation

Heilig, R., Lee, J., & Tait, S. W. G. (2023) · Biochemical Society Transactions · doi:10.1042/bst20221525 · Cited by 56 · see citing works

MARCH5-dependent degradation of MCL1/NOXA complexes defines susceptibility to antimitotic drug treatment

Haschka, M. D., Karbon, G., Soratroi, C., O’Neill, K. L., Luo, X., & Villunger, A. (2020) · Cell Death and Differentiation · doi:10.1038/s41418-020-0503-6 · Cited by 53 · see citing works

Distinct mRNAs That Encode La Autoantigen Are Differentially Expressed and Contain Internal Ribosome Entry Sites

Carter, M. S., & Sarnow, P. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004657200 · Cited by 53 · see citing works

Cleavage of eIF4G by HIV‐1 protease: effects on translation

Perales, C., Carrasco, L., & Ventoso, I. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)03764-x · Cited by 53 · see citing works

Strategies for transcriptional activation by steroid/nuclear receptors

Freedman, L. P. (1999) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(1999)75:32+ · Cited by 26 · see citing works

p58IPK is an inhibitor of the eIF2α kinase GCN2 and its localization and expression underpin protein synthesis and ER processing capacity

Roobol, A., Roobol, J., Bastide, A., Knight, J. R. P., Willis, A. E., & Smales, C. M. (2015) · Biochemical Journal · doi:10.1042/bj20140852 · Cited by 50 · see citing works

Phosphorylation of eIF4GII and 4E-BP1 in response to nocodazole treatment: A reappraisal of translation initiation during mitosis

Coldwell, M. J., Cowan, J. L., Vlasak, M., Mead, A., Willett, M., Perry, L., & Morley, S. (2013) · Cell Cycle · doi:10.4161/cc.26588 · Cited by 50 · see citing works

Translation inhibition during the induction of apoptosis: RNA or protein degradation?

Bushell, M., Stoneley, M., Sarnow, P., & Willis, A. E. (2004) · Biochemical Society Transactions · doi:10.1042/bst0320606 · Cited by 50 · see citing works

Translational control in virus-infected cells: models for cellular stress responses

Clemens, M. J. (2004) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2004.11.011 · Cited by 50 · see citing works

HIV-1 Transcripts Use IRES-Initiation under Conditions Where Cap-Dependent Translation Is Restricted by Poliovirus 2A Protease

Amorim, R., Costa, S. M., Cavaleiro, N. P., da Silva, E. E., & da Costa, L. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088619 · Cited by 49 · see citing works

Multiple eIF4GI-Specific Protease Activities Present in Uninfected and Poliovirus-Infected Cells

Zamora, M., Marissen, W. E., & Lloyd, R. E. (2002) · Journal of Virology · doi:10.1128/jvi.76.1.165-177.2002 · Cited by 48 · see citing works

HLA-G in melanoma: can the current controversies be solved?

Chang, C., & Ferrone, S. (2003) · Seminars in Cancer Biology · doi:10.1016/s1044-579x(03)00027-0 · Cited by 48 · see citing works

EIF2AK2 selectively regulates the gene transcription in immune response and histones associated with systemic lupus erythematosus

Ge, L., Zhang, Y., Zhao, X., Wang, J., Zhang, Y., Wang, Q., Yu, H., Zhang, Y., & You, Y. (2021) · Molecular Immunology · doi:10.1016/j.molimm.2021.01.030 · Cited by 47 · see citing works

Cleavage of eukaryotic translation initiation factor 4GII correlates with translation inhibition during apoptosis

Marissen, W. E., Gradi, A., Sonenberg, N., & Lloyd, R. E. (2000) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400750 · Cited by 73 · see citing works

Identification of Caspase 3-mediated Cleavage and Functional Alteration of Eukaryotic Initiation Factor 2α in Apoptosis

Marissen, W. E., Guo, Y., Thomas, A. A. M., Matts, R. L., & Lloyd, R. E. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.13.9314 · Cited by 77 · see citing works

Caspase‐mediated cleavage and DNase activity of the translation initiation factor 3, subunit G (eIF3g)

Kim, J., Lee, S., Kim, B.-Y., Lee, C., Yeom, Y. I., Choe, Y., Yoon, D., Chae, S., Kim, J. W., Yang, Y. D., et al. (2013) · FEBS Letters · doi:10.1016/j.febslet.2013.09.027 · Cited by 11 · see citing works

Translation initiation factor modifications and the regulation of protein synthesis in apoptotic cells

Clemens, M. J., Bushell, M., Jeffrey, I. W., Pain, V. M., & Morley, S. (2000) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400695 · Cited by 228 · see citing works

All's well that ends well: translational control and cell death

Willis, A. E. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401656 · Cited by 1 · see citing works