The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Human CDC6/Cdc18 Associates with Orc1 and Cyclin-cdk and Is Selectively Eliminated from the Nucleus at the Onset of S Phase
Open accessAbstract
In a two-hybrid screen for proteins that interact with human PCNA, we identified and cloned a human protein (hCdc18) homologous to yeast CDC6/Cdc18 and human Orc1. Unlike yeast, in which the rapid and total destruction of CDC6/Cdc18 protein in S phase is a central feature of DNA replication, the total level of the human protein is unchanged throughout the cell cycle. Epitope-tagged protein is nuclear in G1 and cytoplasmic in S-phase cells, suggesting that DNA replication may be regulated by either the translocation of this protein between the nucleus and the cytoplasm or the selective degradation of the protein in the nucleus. Mutation of the only nuclear localization signal of this protein does not alter its nuclear localization, implying that the protein is translocated to the nucleus through its association with other nuclear proteins. Rapid elimination of the nuclear pool of this protein after the onset of DNA replication and its association with human Orc1 protein and cyclin-cdks supports its identification as human CDC6/Cdc18 protein.
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Citations
Cites
Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA
Chen, J., Jackson, P. K., Kirschner, M. W., & Dutta, A. (1995) · Nature · doi:10.1038/374386a0 · Cited by 548
Self-citationCyclin-Binding Motifs Are Essential for the Function of p21 CIP1
Chen, J., Saha, P., Kornbluth, S., Dynlacht, B. D., & Dutta, A. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.9.4673 · Cited by 320
Self-citation
Cited by
The origin recognition complex: from simple origins to complex functions
Bell, S. P. (2002) · Genes & Development · doi:10.1101/gad.969602 · Cited by 288
A Nontranscriptional Role for HIF-1α as a Direct Inhibitor of DNA Replication
Hubbi, M. E., Kshitiz, Gilkes, D. M., Rey, S., Wong, C. C., Luo, W., Kim, D.-H., Dang, C. V., Levchenko, A., & Semenza, G. L. (2013) · Science Signaling · doi:10.1126/scisignal.2003417 · Cited by 116
ATP-dependent activation of p21 WAF1/CIP1 -associated Cdk2 by Cdc6
Kan, Q., Jinno, S., Yamamoto, H., Kobayashi, K., & Okayama, H. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706392105 · Cited by 19
Metadata
- Authors
- Saha, P., Chen, J., Thome, K. C., Lawlis, S. J., Hou, Z.-H., Hendricks, M., Parvin, J. D., & Dutta, A.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1998-05-01
- Volume
- 18
- Issue
- 5
- Pages
- 2758-2767
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2147891889
- Cited by
- 256
- References
- 2
- FWCI
- 10.41
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Human CDC6/Cdc18 Associates with Orc1 and Cyclin-cdk and Is Selectively Eliminated from the Nucleus at the Onset of S Phase. https://app.cochat.ai/papers/10.1128/mcb.18.5.2758
- The paper
- Saha, P., Chen, J., Thome, K. C., Lawlis, S. J., Hou, Z.-H., Hendricks, M., Parvin, J. D., & Dutta, A. (1998). Human CDC6/Cdc18 Associates with Orc1 and Cyclin-cdk and Is Selectively Eliminated from the Nucleus at the Onset of S Phase. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.18.5.2758
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