The DOI matches its Crossref record; 74 of the 74 references it cites were found in a registry or an index.
Gadd45, a p53-Responsive Stress Protein, Modifies DNA Accessibility on Damaged Chromatin
Open accessAbstract
This report demonstrates that Gadd45, a p53-responsive stress protein, can facilitate topoisomerase relaxing and cleavage activity in the presence of core histones. A correlation between reduced expression of Gadd45 and increased resistance to topoisomerase I and topoisomerase II inhibitors in a variety of human cell lines was also found. Gadd45 could potentially mediate this effect by destabilizing histone-DNA interactions since it was found to interact directly with the four core histones. To evaluate this possibility, we investigated the effect of Gadd45 on preassembled mononucleosomes. Our data indicate that Gadd45 directly associates with mononucleosomes that have been altered by histone acetylation or UV radiation. This interaction resulted in increased DNase I accessibility on hyperacetylated mononucleosomes and substantial reduction of T4 endonuclease V accessibility to cyclobutane pyrimidine dimers on UV-irradiated mononucleosomes but not on naked DNA. Both histone acetylation and UV radiation are thought to destabilize the nucleosomal structure. Hence, these results imply that Gadd45 can recognize an altered chromatin state and modulate DNA accessibility to cellular proteins.
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Cited by
Cortellino, S., Xu, J., Sannai, M., Moore, R., Caretti, E., Cigliano, A., Le Coz, M., Devarajan, K., Wessels, A., Soprano, D., et al. (2011) · Cell · doi:10.1016/j.cell.2011.06.020 · Cited by 809
Ziv, Y., Bielopolski, D., Galanty, Y., Lukas, C., Taya, Y., Schultz, D. C., Lukas, J., Bekker-Jensen, S., Bartek, J., & Shiloh, Y. (2006) · Nature Cell Biology · doi:10.1038/ncb1446 · Cited by 735
Gadd45 in Stress Signaling, Cell Cycle Control, and Apoptosis
Salvador, J. M., Brown-Clay, J. D., & Fornace, A. J. (2013) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4614-8289-5_1 · Cited by 308
Self-citationUltraviolet radiation and cutaneous malignant melanoma
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The p400 ATPase regulates nucleosome stability and chromatin ubiquitination during DNA repair
Xu, Y., Sun, Y., Jiang, X., Ayrapetov, M. K., Moskwa, P., Yang, S., Weinstock, D. M., & Price, B. D. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201001160 · Cited by 194
Metadata
- Authors
- Carrier, F., Georgel, P. T., Pourquier, P., Blake, M., Kontny, H. U., Antinore, M. J., Gariboldi, M., Myers, T. G., Weinstein, J. N., Pommier, Y., & Fornace, A. J.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1999-03-01
- Volume
- 19
- Issue
- 3
- Pages
- 1673-1685
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W1918117223
- Cited by
- 277
- References
- 74
- FWCI
- 6.63
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Gadd45, a p53-Responsive Stress Protein, Modifies DNA Accessibility on Damaged Chromatin. https://app.cochat.ai/papers/10.1128/mcb.19.3.1673
- The paper
- Carrier, F., Georgel, P. T., Pourquier, P., Blake, M., Kontny, H. U., Antinore, M. J., Gariboldi, M., Myers, T. G., Weinstein, J. N., Pommier, Y., & Fornace, A. J. (1999). Gadd45, a p53-Responsive Stress Protein, Modifies DNA Accessibility on Damaged Chromatin. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.19.3.1673
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
