Shp-2 Tyrosine Phosphatase Functions as a Negative Regulator of the Interferon-Stimulated Jak/STAT Pathway

Cited by (365)

Items 301–365 of 365

1. JAK-STAT signaling pathway in cancer: from molecular mechanisms to clinical intervention
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2. Computational study on the binding mechanism of allosteric drug TNO155 inhibiting SHP2E76A
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3. Oral zinc sulphate reduces the recurrence rate and provides significant therapeutic effects for viral warts: A systematic review and meta-analysis of randomized controlled trials
   Chen‐Chi Wang, Wei-Xiang Wang, Po‐Yuan Wu · 2025 · PLoS ONE
4. SFX-01 is therapeutic against myeloproliferative disorders caused by activating mutations in Shp2
   Hyun‐Ju Cho, Joy Smith, Christopher Switzer, Eleni Louka, Rebecca L. Charles, Oleksandra D. Prysyazhna, Ewald Schröder, Mariana Fernández-Caggiano, Daniel Simões de Jesus, Seda Eminaga et al. · 2025 · EMBO Molecular Medicine
5. Regulation of the Jak/STATs Pathways by Histone Deacetylases
   David Michael Woods, Maritza Lienlaf, Eduardo M. Sotomayor, Edward Seto, Alejandro Villagra · 2013 · Cancer drug discovery and develogment/Cancer drug discovery and development
6. Identification of trans-Acting Factors by Electrophoretic Mobility Shift Assay
   Rebecca J. Chan, Min You, Gen‐Sheng Feng · 2003 · Humana Press eBooks
7. Signalling by Cytokines
   William L. Farrar, Lihua Wang, Xiaoyi Yang, Weihua Xiao, O. M. Zack Howard, Colin S. Duckett · 2005 · The Cancer Handbook
8. A True Jak of All Trades
   Eric M. Sandberg, Tiffany A. Wallace, Michael D. Godeny, Peter P. Sayeski · 2004
9. The tumor promoter 12-O-tetradecanoylphorbol-13-acetate suppresses cell proliferation in metastatic melanoma through TC-PTP/PTPN2 and SH-PTP2/PTPN11
   Yuki Akamatsu, Mami Onishi, Taiki Nagano, Masahiro Oka, Shinji Kamada, Tetsushi Iwasaki · 2025 · The Journal of Biochemistry
10. Targeting the glioblastoma-initiating cell-associated antigens
    2016 · Cancer Cell & Microenvironment
11. Small Molecule Degraders Targeting the SHP2E76A Mutant Effectively Inhibiting the Proliferation of Wild-type and Mutant SHP2 Dependent Tumor Cells
    Jiao Kong, Lin Du, Xiangyang Li, Jidong Zhu, Ya‐Qiu Long · 2023 · 化学学报
12. Pharmacological inhibition of the Src homology phosphatase 2 confers partial protection in a mouse model of alcohol-associated liver disease
    Ming-Fo Hsu, Shinichiro Koike, Chang-Shan Chen, Sonia Michael Najjar, Tzu‐Ching Meng, Fawaz G. Haj · 2024 · Biomedicine & Pharmacotherapy
13. Regulation of Cytokine Signaling During Macrophage Differentiation and Activation
    Ilkka Junttila · 2005 · Tampere University Institutional Repository (Tampere University)
14. Post-translational Modifications in Regulation of Jak-stat Pathway
    Daniela Ungureanu · 2005 · Tampere University Institutional Repository (Tampere University)
15. Cytokine-Activated JAK-STAT Signaling in the Mouse Immune System
    Bowen Liu, Ke Shuai · 2007 · Elsevier eBooks
16. Role of Interferon-Gamma and Leucine-Rich Repeat Kinase 2 in Stress-Related Pathology
    Darcy Litteljohn · 2016
17. Bystander IFN-y activity promotes widespread and sustained cytokine signaling altering the tumor microenvironment
    Ronan Thibaut · 2019 · theses.fr (ABES)
18. Cytokine Signaling in Tissue Engineering
    Thomas Meyer, Volker Ruppert, Bernhard Maisch · 2009 · Springer eBooks
19. Identification of two tyrosine kinase like proteins as important modulators of the STATc-mediated response to hyperosmolarity
    Linh Hai Vu · 2013 · Kölner Universitäts PublikationsServer (Universität zu Köln)
20. The Role of RPTP-Alpha-Like Protein Tyrosine Phosphatases in Mammary Tumorigenesis
    Jan Sap · 2001
21. Funktionalität des Interferon TypI- und TypII-Signalwegs in Burkitt-Lymphom-Zellen
    Judith Mergler · 2008 · Electronic Theses of LMU Munich (Ludwig-Maximilians-Universität München)
22. The role of Src-homology 2 domain-containing tyrosine phosphatase 2 in signaling and tumorigenesis of basal type/triple negative breast cancer
    Fatimah Kh. Matalkah · 2012
23. Human beta defensin 3 induction in gastric epithelial cells under Helicobacter pylori infection and cytokine dependent modulation
    Lennart Pfannkuch · 2014 · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver
24. Role of type I Interferons in the treatment of endocrine and non-endocrine cancers
    Giovanni Vitale · 2006 · Università degli Studi di Napoli Federico II
25. The Significance of FRS2 Phosphorylation in EGF- and FGF-Induced Signaling
    Yingjie Wu · 2003
26. The Role of Phosphatases and Reactive Oxygen Species in Regulation of the JAK/STAT Pathway
    Andrew C. Larner, Michael David · 2003 · Springer eBooks
27. Cutaneous Squamous Cell Carcinoma: Focus on Biochemical and Molecular Characteristics
    Michele Caraglia, Giovanni Francesco Nicoletti, Angela Lombardi, Gerardo Botti, Renato Franco · 2013 · Springer eBooks
28. Review Signaling by STATs
    Lionel B. Ivashkiv, Xiaoyu Hu · 2013
29. Deciphering a Kit-Shp2-Kit Axis in Regulation of Adult Hematopoietic Stem and Progenitor Cells
    He Zhu · 2011 · eScholarship (California Digital Library)
30. La Via JAK/STAT com a mediadora de respostes a l'estrès oxidatiu, la inflamació i la immunitat innata en astròcits
    Roser Gorina · 2008 · Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona)
31. Jak2 TYROSINE KINASE: NEW INSIGHTS REGARDING STRUCTURE, FUNCTION, AND PHARMACOLOGY
    Eric M. Sandberg · 2004
32. JAK2 AND SRC FAMILY TYROSINE KINASE SIGNALING VIA THE ANGIOTENSIN II TYPE 1 RECEPTOR
    Michael D. Godeny · 2006
33. The role of parallel signaling pathways in maintaining lymphoid cell survival
    Zsuzsanna S. Nagy, Robert Arthur Kirken · 2002
34. SHP-1/STAT3訊息傳遞路徑於肝癌標靶治療之分子機制研究
    戴瑋恬, Wei‐Tien Tai · 2012
35. Inhibition of type I and type II interferon signaling by alphavirus nonstructural proteins
    Jason D. Simmons · 2019 · Carolina Digital Repository (University of North Carolina at Chapel Hill)
36. Unmet Medical Needs in Non-Small-Cell Lung Cancer Treatment: How to Design Pre-Emptive Combination Therapies
    Niki Karachaliou, Rafael Rosell · 2014 · EMJ Oncology
37. Study of molecular and immunological factors that determine the sensitivity to the antitumor effect of Tumor Necrosis Factor
    Leander Huyghe · 2008 · Ghent University Academic Bibliography (Ghent University)
38. Identifizierung und Charakterisierung von IFNγ-regulierten Effektormolekülen in der antimikrobiellen Immunantwort
    Klaus Pfeffer · 2013
39. Cytokines and Signaling
    Michael David · 2005 · CRC Press eBooks
40. Understanding Interferon: Translating Biologic Advances into Clinical Progress
    Gregory B. Lesinski, William Edgar Carson · 2008 · CRC Press eBooks
41. Cytokine receptors and signal transduction
    Ivo PTouw andThamar B van Dijk · 2010 · Taylor & Francis eBooks
42. A functional analysis of the Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor
    Mark Cannon · 2007 · Doctoral thesis, University of London.
43. Signal Transducer and Activator of Transcription 6 (STAT6) as a regulator of pancreatic beta cell health
    Kaiyven Afi Leslie · 2019 · Figshare
44. Biological Evaluation of Aminobenzoic Acid Derivatives against SHP2
    祥东 孟 · 2021 · Hans Journal of Medicinal Chemistry
45. Cytokine receptors and signal transduction
    Ivo P. Touw, Thamar van Dijk · 2004 · CRC Press eBooks
46. Interferon-α2b
    Anand Rotte, Madhuri Bhandaru · 2016 · Springer eBooks
47. Understanding Interferon: Translating Biologic Advances into Clinical Progress
    Gregory B. Lesinski, William Edgar Carson · 2008 · Translational medicine series
48. Signalling by Cytokines
    Brian T. Kawasaki, O. M. Zack Howard, Ana M. Gamero, William L. Farrar · 2007 · The Cancer Handbook
49. Activation of SH2 domain-containing protein tyrosine phosphatase and inflammatory expression in psoriasis
    Bui Kieu Trang, Nguyen Thi Kim Lien, Nguyễn Thị Xuân · 2022 · Vietnam Journal of Biotechnology
50. Expression of several deubiquitinase and tyrosine phosphatase genes involved in inflammatory response in lymphoma
    Nguyen Hoang Giang, Nguyen Trong Ha, Nguyễn Thị Xuân · 2024 · Ministry of Science and Technology Vietnam
51. A20 promoted the phagocytosis of lymphoma cells by dendritic cells from activated B-cell-like non-Hodgkin lymphoma
    Nguyen Trong Ha, Do Thi Trang, Pham Viet Nhat, Phạm Thị Mai Hương, Nguyen Hoang Giang, Cấn Văn Mão, Vu Duc Binh, Nguyen Ba Vuong, Nguyễn Thị Xuân · 2024 · Cellular and Molecular Biology
52. Oncogene functions in human cancer
    Tang, Jianzhong · 2010 · ResearchSpace (University of Auckland)
53. Immune Checkpoint Inhibitor-Induced Cardiovascular Disease: The Role of Accelerated Senescence in Vascular Dysfunction
    Bernardo Casso-Chapa, Angelica Paniagua-Bojorges, Nicolas L. Palaskas, Kevin Thomas Nead, Venkata Subrahman K Samanthapudi, Jonghae Lee, Gilbert F. Mejia, Oanh N. Hoang, Jung Hyun Kim, Steven Hsesheng Lin et al. · 2026 · Antioxidants and Redox Signaling
54. Novel heterozygous STAT3 mutations clarify the molecular basis of the hyper IgE syndrome
    Joëlle Khourieh · 2018
55. Impact de la protéine SHP2 associé au syndrome de Noonan sur le métabolisme glucidique
    Romain Paccoud · 2018
56. Identification et caractérisation d'une nouvelle forme de défaut partiel récessif héréditaire en JAK1 chez l'homme
    Valentine Jeanne-Julien · 2019
57. La plaquette sanguine : un nouvel acteur du syndrome hémorragique de Noonan et du développement des maladies métaboliques
    Marie Bellio · 2020
58. Connective tissue growth in a mouse model of Kosaki overgrowth syndrome is limited by STAT1
    Jang Hwan Kim, Hae Ryong Kwon, William L. Berry, Lorin E. Olson · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
59. Tumor-intrinsic expression of signal regulatory protein α contributes to the suppression of anti-tumor immune responses
    Chien‐Huan Weng, Chana Schochet, Vincent Panneton, Anaïs Assouvie, Shabnam Z Eghbali, Sébastien Monette, Cailian Liu, Yacine Marouf, Levi Mark B Mangarin, Lucia Morgado-Palacin et al. · 2026 · Cell Reports
60. JAK Kinases in Leukemias, Lymphomas, and Multiple Myeloma
    R. Burger, M. Gramatzki · 2006 · Humana Press eBooks
61. Protein degraders targeting JAK/STAT3 signaling pathway are emerging therapeutic modalities for human cancers
    Xinyu Feng, Nanjing Li, Xiaorong Chen, Xinyue Cao, Jingling Dai, Shaoquan Xiong, Zhu Yuan · 2026 · Biochemical Pharmacology
62. BindingDB Entry 50011296: Recent Advances of SHP2 Inhibitors in Cancer Therapy: Current Development and Clinical Application.
    BindingDB · 2022 · UC San Diego
63. BindingDB Entry 50032714: Shp2 protein tyrosine phosphatase inhibitor activity of estramustine phosphate and its triterpenoid analogs.
    BindingDB · 2011 · UC San Diego
64. The role of STAT1 in Chlamydia-induced type I interferon responses in oviduct epithelium
    Kristen L. Hosey · 2013 · IUScholarWorks (Indiana University)
65. Biological Roles of the STAT Family in Cytokine Signaling
    Kiyoshi Takeda, Shizuo Akira · 2004 · Handbook of experimental pharmacology