The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Hepatocyte-Specific Mutation Establishes Retinoid X Receptor α as a Heterodimeric Integrator of Multiple Physiological Processes in the Liver
Open accessAbstract
A large number of physiological processes in the adult liver are regulated by nuclear receptors that require heterodimerization with retinoid X receptors (RXRs). In this study, we have used cre-mediated recombination to disrupt the mouse RXRalpha gene specifically in hepatocytes. Although such mice are viable, molecular and biochemical parameters indicate that every one of the examined metabolic pathways in the liver (mediated by RXR heterodimerization with PPARalpha, CARbeta, PXR, LXR, and FXR) is compromised in the absence of RXRalpha. These data demonstrate the presence of a complex circuitry in which RXRalpha is integrated into a number of diverse physiological pathways as a common regulatory component of cholesterol, fatty acid, bile acid, steroid, and xenobiotic metabolism and homeostasis.
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Cites
Endogenous Bile Acids Are Ligands for the Nuclear Receptor FXR/BAR
Wang, H., Chen, J., Hollister, K., Sowers, L. C., & Forman, B. M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80348-2 · Cited by 1,636
Self-citationRussell, D. W., & Setchell, K. D. R. (1992) · Biochemistry · doi:10.1021/bi00135a001 · Cited by 819
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Regulation of glutathione synthesis
Lu, S. C. (2009) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2008.05.005 · Cited by 2,116
The Enzymes, Regulation, and Genetics of Bile Acid Synthesis
Russell, D. W. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161712 · Cited by 2,069
Godoy, P., Hewitt, N. J., Albrecht, U., Andersen, M. E., Ansari, N., Bhattacharya, S., Bode, J. G., Bolleyn, J., Borner, C., Böttger, J., et al. (2013) · Archives of Toxicology · doi:10.1007/s00204-013-1078-5 · Cited by 1,280
Hayhurst, G. P., Lee, Y.-H., Lambert, G., Ward, J. M., & Gonzalez, F. J. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.4.1393-1403.2001 · Cited by 1,107
Metabolism and function of coenzyme Q
Turunen, M., Olsson, J., & Dallner, G. (2004) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2003.11.012 · Cited by 1,026
Metadata
- Authors
- Wan, Y.-J. Y., An, D., Cai, Y., Repa, J. J., Hung-Po Chen, T., Flores, M., Postic, C., Magnuson, M. A., Chen, J., Chien, K. R., French, S., Mangelsdorf, D. J., & Sucov, H. M.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2000-06-01
- Volume
- 20
- Issue
- 12
- Pages
- 4436-4444
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2115248104
- Cited by
- 228
- References
- 2
- FWCI
- 7.55
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Wan, Y.-J. Y., An, D., Cai, Y., Repa, J. J., Hung-Po Chen, T., Flores, M., Postic, C., Magnuson, M. A., Chen, J., Chien, K. R., French, S., Mangelsdorf, D. J., & Sucov, H. M. (2000). Hepatocyte-Specific Mutation Establishes Retinoid X Receptor α as a Heterodimeric Integrator of Multiple Physiological Processes in the Liver. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.20.12.4436-4444.2000
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
