The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Involvement of the MKK6-p38γ Cascade in γ-Radiation-Induced Cell Cycle Arrest
Open accessAbstract
The p38 group of kinases belongs to the mitogen-activated protein (MAP) kinase superfamily with structural and functional characteristics distinguishable from those of the ERK, JNK (SAPK), and BMK (ERK5) kinases. Although there is a high degree of similarity among members of the p38 group in terms of structure and activation, each member appears to have a unique function. Here we show that activation of p38gamma (also known as ERK6 or SAPK3), but not the other p38 isoforms, is required for gamma-irradiation-induced G(2) arrest. Activation of the MKK6-p38gamma cascade is sufficient to induce G(2) arrest in cells, and expression of dominant negative alleles of MKK6 or p38gamma allows cells to escape the DNA damage-induce G(2) delay. Activation of p38gamma is dependent on ATM and leads to activation of Cds1 (also known as Chk2). These data suggest a model in which activation of ATM by gamma irradiation leads to the activation of MKK6, p38gamma, and Cds1 and that activation of both MKK6 and p38gamma is essential for the proper regulation of the G(2) checkpoint in mammalian cells.
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Citations
Cites
Independent Human MAP-Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms
Dérijard, B., Raingeaud, J., Barrett, T., Wu, I.-H., Han, J., Ulevitch, R. J., & Davis, R. J. (1995) · Science · doi:10.1126/science.7839144 · Cited by 1,555 · cited 8×
“Two MAP kinase kinases, MKK3 and MKK6, have been identified as immediate upstream activators of the p38 family (13).”
BackgroundMethodInfluentialSelf-citationSanchez, Y., Wong, C., Thoma, R. S., Richman, R., Wu, Z., Piwnica-Worms, H., & Elledge, S. J. (1997) · Science · doi:10.1126/science.277.5331.1497 · Cited by 1,320
Caffeine inhibits the checkpoint kinase ATM
Blasina, A., Price, B. D., Turenne, G. A., & McGowan, C. H. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80486-2 · Cited by 295
Self-citation
Cited by
Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints
Sancar, A., Lindsey-Boltz, L. A., Ünsal-Kaçmaz, K., & Linn, S. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.073723 · Cited by 3,317
ATM and related protein kinases: safeguarding genome integrity
Shiloh, Y. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1011 · Cited by 2,577
Differential regulation and properties of MAPKs
Raman, M., Chen, W., & Cobb, M. H. (2007) · Oncogene · doi:10.1038/sj.onc.1210392 · Cited by 1,430
DNA damage responses to oxidative stress
Barzilai, A., & Yamamoto, K.-I. (2004) · DNA Repair · doi:10.1016/j.dnarep.2004.03.002 · Cited by 796
Chen, X.-L., Dodd, G., Thomas, S., Zhang, X., Wasserman, M. A., Rovin, B. H., & Kunsch, C. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00651.2005 · Cited by 418
Metadata
- Authors
- Wang, X., McGowan, C. H., Zhao, M., He, L., Downey, J. S., Fearns, C., Wang, Y., Huang, S., & Han, J.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2000-07-01
- Volume
- 20
- Issue
- 13
- Pages
- 4543-4552
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2011549770
- Cited by
- 249
- References
- 3
- FWCI
- 6.42
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Involvement of the MKK6-p38γ Cascade in γ-Radiation-Induced Cell Cycle Arrest. https://app.cochat.ai/papers/10.1128/mcb.20.13.4543-4552.2000
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- Wang, X., McGowan, C. H., Zhao, M., He, L., Downey, J. S., Fearns, C., Wang, Y., Huang, S., & Han, J. (2000). Involvement of the MKK6-p38γ Cascade in γ-Radiation-Induced Cell Cycle Arrest. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.20.13.4543-4552.2000
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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