The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Defects in Nuclear and Cytoskeletal Morphology and Mitochondrial Localization in Spermatozoa of Mice Lacking Nectin-2, a Component of Cell-Cell Adherens Junctions
Open accessAbstract
Nectin-2 is a cell adhesion molecule encoded by a member of the poliovirus receptor gene family. This family consists of human, monkey, rat, and murine genes that are members of the immunoglobulin gene superfamily. Nectin-2 is a component of cell-cell adherens junctions and interacts with l-afadin, an F-actin-binding protein. Disruption of both alleles of the murine nectin-2 gene resulted in morphologically aberrant spermatozoa with defects in nuclear and cytoskeletal morphology and mitochondrial localization. Homozygous null males are sterile, while homozygous null females, as well as heterozygous males and females, are fertile. The production by nectin-2(-/-) mice of normal numbers of spermatozoa containing wild-type levels of DNA suggests that Nectin-2 functions at a late stage of germ cell development. Consistent with such a role, Nectin-2 is expressed in the testes only during the later stages of spermatogenesis. The structural defects observed in spermatozoa of nectin-2(-/-) mice suggest a role for this protein in organization and reorganization of the cytoskeleton during spermiogenesis.
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Cites
Effects of an Igf1 Gene Null Mutation on Mouse Reproduction
Baker, J., Hardy, M. P., Zhou, J., Bondy, C., Lupu, F., Bellvé, A. R., & Efstratiadis, A. (1996) · Molecular Endocrinology · doi:10.1210/mend.10.7.8813730 · Cited by 674
Cited by
Cheng, C. Y., & Mruk, D. D. (2002) · Physiological Reviews · doi:10.1152/physrev.00009.2002 · Cited by 567
Regulation of cell polarity by cell adhesion receptors
Ebnet, K., Kummer, D., Steinbacher, T., Singh, A., Nakayama, M., & Matis, M. (2018) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2017.07.032 · Cited by 52
Expression patterns of nectins and afadin during epithelial remodeling in the mouse embryo
Okabe, N., Ozaki‐Kuroda, K., Nakanishi, H., Shimizu, K., & Takai, Y. (2004) · Developmental Dynamics · doi:10.1002/dvdy.20033 · Cited by 35
Metadata
- Authors
- Bouchard, M. J., Dong, Y., McDermott, B. M., Lam, D.-H., Brown, K. R., Shelanski, M., Bellvé, A. R., & Racaniello, V. R.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2000-04-01
- Volume
- 20
- Issue
- 8
- Pages
- 2865-2873
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2096364907
- Cited by
- 167
- References
- 1
- FWCI
- 9.15
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Bouchard, M. J., Dong, Y., McDermott, B. M., Lam, D.-H., Brown, K. R., Shelanski, M., Bellvé, A. R., & Racaniello, V. R. (2000). Defects in Nuclear and Cytoskeletal Morphology and Mitochondrial Localization in Spermatozoa of Mice Lacking Nectin-2, a Component of Cell-Cell Adherens Junctions. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.20.8.2865-2873.2000
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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