Expression patterns of nectins and afadin during epithelial remodeling in the mouse embryo
Open accessAbstract
Cell–cell adhesion plays key roles in tissue morphogenesis and organogenesis. Nectins are Ca 2+‐independent immunoglobulin‐like cell adhesion molecules connected to the actin cytoskeleton through afadin. Nectins play roles in a variety of cell–cell junctions in cooperation with or independently of cadherins. Here, we examined the cellular localization of nectins and afadin throughout primitive streak, neural plate, and early organogenesis stages of mouse development. Nectin and afadin localization coincided with a honeycomb‐shaped meshwork of actin filaments at adherens junctions of polarized epithelia, including neuroepithelium, epithelial somites, and facial primordia. As organogenesis progressed, nectin‐2 expression was maintained in general columnar epithelia, whereas nectin‐1 and ‐3 became highly concentrated at sites of neural morphogenesis. Moreover, nectin‐1 was highly expressed in keratinocytes of the skin, developing hair follicles, and epithelium of developing teeth. These results suggest that nectins and afadin are involved in dynamic epithelial remodeling during mouse development. Developmental Dynamics 230:174–186, 2004. © 2004 Wiley‐Liss, Inc.
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NECTIN signaling has a role in cell adhesion and skin morphogenesis.
“given its role in cell adhesion and skin morphogenesis.56”
From Single-cell transcriptomics of human-skin-equivalent organoids (2023) · cites this paper as [56]
The Introduction describes the nectin–afadin system as a component of cell–cell adhesion and links nectin-1 mutations to abnormalities of skin, hair, and teeth. The Ectodermal Stratified Epithelia section reports nectin-1 expression in developing skin but says its role there remains elusive. The paper therefore supports a possible role in skin morphogenesis, not an established role for nectin signaling in that process. (LLM, conf=0.84)
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Cites
Molecular Mechanisms Regulating Hair Follicle Development
Millar, S. E. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01670.x · Cited by 967 · see citing works
Mueller, S., & Wimmer, E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304166200 · Cited by 90 · see citing works
E‐ and P‐cadherin expression during murine hair follicle morphogenesis and cycling
Müller‐Röver, S., Tokura, Y., Welker, P., Furukawa, F., Wakita, H., Takigawa, M., & Paus, R. (1999) · Experimental Dermatology · doi:10.1111/j.1600-0625.1999.tb00377.x · Cited by 86 · see citing works
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Research works printed but not linked: 2
- Hogan B, Beddington R, Costantini F, Lacy E. 1994. Manipulating the mouse embryo. New York: Cold Spring Harbor Laboratory Press. 497 p.
- Kaufman MH. 1992. The atlas of mouse development. San Diego: Academic Press. 525 p.
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Single-cell transcriptomics of human-skin-equivalent organoids
Stabell, A. R., Lee, G. E., Jia, Y., Wong, K. N., Wang, S., Ling, J., Nguyen, S. D., Sen, G. L., Nie, Q., & Atwood, S. X. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112511 · Cited by 30 · see citing works
- Authors
- Okabe, N., Ozaki‐Kuroda, K., Nakanishi, H., Shimizu, K., & Takai, Y.
- Affiliations
- The University of Osaka (JP)
- Corresponding author
- Takai, Yoshimi
- Venue
- Developmental Dynamics
- Publisher
- Wiley
- Published
- 2004-03-31
- Volume
- 230
- Issue
- 1
- Pages
- 174-186
- ISSN
- 1058-8388 (ISSN-L)
- 1097-0177
- OpenAlex
- W2018716000
- Cited by
- 35
- References
- 3
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2019: 1 · 2018: 1 · 2016: 4 · 2014: 3 · 2013: 1 · 2012: 1
- FWCI
- 1.15
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Developmental Dynamics (publishedVersion)
- PubMed (publishedVersion)
- Tokyo Tech Research Repository (Tokyo Institute of Technology) (submittedVersion)
- Funders
- RIKEN
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Keywords
- nectin, afadin, nectin-1, nectin-2, nectin-3, cell-cell adhesion, adherens junctions, epithelial remodeling, mouse embryo, neuronal morphogenesis, organogenesis, neuroepithelium, keratinocytes, hair follicle, actin cytoskeleton
- MeSH terms
- Nectins, Actins, Animals, Calcium, Cell Adhesion, Cytoskeleton, Epithelium, Immunoglobulins, Intercellular Junctions, Mice, Inbred ICR, Microfilament Proteins, Microscopy, Fluorescence, Myosins, Nucleic Acid Hybridization, RNA, Messenger, Time Factors, Tooth, Blotting, Western, Cell Adhesion Molecules, Kinesins, In Situ Hybridization, DNA, Complementary, Gene Expression Regulation, Developmental, Protein Isoforms, Adherens Junctions, Mice
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