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Regulation of the Pancreatic Islet-Specific Gene BETA2 ( neuroD ) by Neurogenin 3
Open accessAbstract
The BETA2 (neuroD) gene is expressed in endocrine cells during pancreas development and is essential for proper islet morphogenesis. The objective of this study is to identify potential upstream regulators of the BETA2 gene during pancreas development. We demonstrated that the expression of neurogenin 3 (ngn3), an islet- and neuron-specific basic-helix-loop-helix transcription factor, partially overlaps that of BETA2 during early mouse development. More importantly, overexpression of ngn3 can induce the ectopic expression of BETA2 in Xenopus embryos and stimulate the endogenous RNA of BETA2 in endocrine cell lines. Furthermore, overexpression of ngn3 could cause a dose-dependent activation on the 1.0-kb BETA2 promoter in islet-derived cell lines. Deletion and mutation analyses revealed that two proximal E box sequences, E1 and E3, could bind to ngn3-E47 heterodimer and mediate ngn3 activation. Based on these results, we hypothesize that ngn3 is involved in activating the expression of BETA2 at an early stage of islet cell differentiation through the E boxes in the BETA2 promoter.
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Cites
The Leucine Zipper: A Hypothetical Structure Common to a New Class of DNA Binding Proteins
Landschulz, W. H., Johnson, P. F., & McKnight, S. L. (1988) · Science · doi:10.1126/science.3289117 · Cited by 3,443
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Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms.
Sun, Y., Nadal-Vicens, M., Misono, S., Lin, M. Z., Zubiaga, A., Hua, X., Fan, G., & Greenberg, M. E. (2001) · Cell · doi:10.1016/s0092-8674(01)00224-0 · Cited by 681
Expression of neurogenin3 reveals an islet cell precursor population in the pancreas
Schwitzgebel, V. M., Scheel, D. W., Conners, J. R., Kalamaras, J., Lee, J. E., Anderson, D. J., Sussel, L., Johnson, J. D., & German, M. S. (2000) · Development · doi:10.1242/dev.127.16.3533 · Cited by 678
A bipotential precursor population for pancreas and liver within the embryonic endoderm
Deutsch, G., Jung, J., Zheng, M., Lóra, J., & Zaret, K. S. (2001) · Development · doi:10.1242/dev.128.6.871 · Cited by 611
Developmental biology of the pancreas: A comprehensive review
Gittes, G. K. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2008.10.024 · Cited by 451
Minireview: Development and Differentiation of Gut Endocrine Cells
Schonhoff, S. E., Giel-Moloney, M., & Leiter, A. B. (2004) · Endocrinology · doi:10.1210/en.2004-0051 · Cited by 322
Metadata
- Authors
- Huang, H.-P., Liu, M., El-Hodiri, H. M., Chu, K., Jamrich, M., & Tsai, M.-J.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2000-05
- Volume
- 20
- Issue
- 9
- Pages
- 3292-3307
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2142201990
- Cited by
- 281
- References
- 1
- FWCI
- 13.66
- Type
- journal article
- Language
- en
- Open access
- green
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- Huang, H.-P., Liu, M., El-Hodiri, H. M., Chu, K., Jamrich, M., & Tsai, M.-J. (2000). Regulation of the Pancreatic Islet-Specific Gene BETA2 ( neuroD ) by Neurogenin 3. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.20.9.3292-3307.2000
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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