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Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms.

Sun, Yi, Nadal-Vicens, Mireya, Misono, Stephanie, Lin, Michael Z., Zubiaga, Ana, Hua, Xianxing, Fan, Guoping, Greenberg, Michael E.·2001·Cell
DOI 10.1016/s0092-8674(01)00224-0
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Abstract

The mechanisms by which neural stem cells give rise to neurons, astrocytes, or oligodendrocytes are beginning to be elucidated. However, it is not known how the specification of one cell lineage results in the suppression of alternative fates. We find that in addition to inducing neurogenesis, the bHLH transcription factor neurogenin (Ngn1) inhibits the differentiation of neural stem cells into astrocytes. While Ngn1 promotes neurogenesis by functioning as a transcriptional activator, Ngn1 inhibits astrocyte differentiation by sequestering the CBP-Smad1 transcription complex away from astrocyte differentiation genes, and by inhibiting the activation of STAT transcription factors that are necessary for gliogenesis. Thus, two distinct mechanisms are involved in the activation and suppression of gene expression during cell-fate specification by neurogenin.

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Research works printed but not linked: 48

  1. Anderson, 1993, Cell fate determination in the peripheral nervous system, J. Neurobiol, 24, 185, 10.1002/neu.480240206 · DOI
  2. Ben-Arie, 1997, Math1 is essential for genesis of cerebellar granule neurons, Nature, 390, 169, 10.1038/36579 · DOI
  3. Bonni, 1993, Characterization of a pathway for ciliary neurotrophic factor signaling to the nucleus, Science, 262, 1575, 10.1126/science.7504325 · DOI
  4. Bonni, 1997, Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway, Science, 278, 477, 10.1126/science.278.5337.477 · DOI
  5. Burrows, 1997, Response diversity and the timing of progenitor cell maturation are regulated by developmental changes in EGFR expression in the cortex, Neuron, 19, 251, 10.1016/S0896-6273(00)80937-X · DOI
  6. Cau, 1997, Mash1 activates a cascade of bHLH regulators in olfactory neuron progenitors, Development, 124, 1611, 10.1242/dev.124.8.1611 · DOI
  7. Farah, 2000, Generation of neurons by transient expression of neural bHLH proteins in mammalian cells, Development, 127, 693, 10.1242/dev.127.4.693 · DOI
  8. Fode, 1998, The bHLH protein NEUROGENIN 2 is a determination factor for epibranchial placode-derived sensory neurons, Neuron, 20, 483, 10.1016/S0896-6273(00)80989-7 · DOI
  9. Fode, 2000, A role for neural determination genes in specifying the dorsoventral identity of telencephalic neurons, Genes Dev, 14, 67, 10.1101/gad.14.1.67 · DOI · Paper page
  10. Gage, 1995, Isolation, characterization, and use of stem cells from the CNS, Annu. Rev. Neurosci, 18, 159, 10.1146/annurev.ne.18.030195.001111 · DOI
  11. Gaiano, 2000, Radial glial identity is promoted by Notch1 signaling in the murine forebrain, Neuron, 26, 395, 10.1016/S0896-6273(00)81172-1 · DOI
  12. Ghosh, 1995, Distinct roles for bFGF and NT-3 in the regulation of cortical neurogenesis, Neuron, 15, 89, 10.1016/0896-6273(95)90067-5 · DOI
  13. Gradwohl, 1996, Restricted expression of a novel murine atonal-related bHLH protein in undifferentiated neural precursors, Dev. Biol, 180, 227, 10.1006/dbio.1996.0297 · DOI
  14. Gross, 1996, Bone morphogenetic proteins promote astroglial lineage commitment by mammalian subventricular zone progenitor cells, Neuron, 17, 595, 10.1016/S0896-6273(00)80193-2 · DOI
  15. Guillemot, 1993, Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons, Cell, 75, 463, 10.1016/0092-8674(93)90381-Y · DOI
  16. Hoodless, 1996, MADR1, a MAD-related protein that functions in BMP2 signaling pathways, Cell, 85, 489, 10.1016/S0092-8674(00)81250-7 · DOI
  17. Horvai, 1997, Nuclear integration of JAK/STAT and Ras/AP-1 signaling by CBP and p300, Proc. Natl. Acad. Sci. USA, 94, 1074, 10.1073/pnas.94.4.1074 · DOI
  18. Huang, 2000, Regulation of the pancreatic islet-specific gene BETA2 (neuroD) by neurogenin 3, Mol. Cell. Biol, 20, 3292, 10.1128/MCB.20.9.3292-3307.2000 · DOI
  19. Johansson, 1999, Identification of a neural stem cell in the adult mammalian central nervous system, Cell, 96, 25, 10.1016/S0092-8674(00)80956-3 · DOI
  20. Johe, 1996, Single factors direct the differentiation of stem cells from the fetal and adult central nervous system, Genes Dev, 10, 3129, 10.1101/gad.10.24.3129 · DOI
  21. Kageyama, 1997, bHLH transcription factors and mammalian neuronal differentiation, Int. J. Biochem. Cell Biol, 29, 1389, 10.1016/S1357-2725(97)89968-2 · DOI
  22. Kamei, 1996, A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors, Cell, 85, 403, 10.1016/S0092-8674(00)81118-6 · DOI · Paper page
  23. Koyano-Nakagawa, 1999, Activation of xenopus genes required for lateral inhibition and neuronal differentiation during primary neurogenesis, Mol. Cell. Neurosci, 14, 327, 10.1006/mcne.1999.0783 · DOI
  24. Lehming, 1994, An HMG-like protein that can switch a transcriptional activator to a repressor, Nature, 371, 175, 10.1038/371175a0 · DOI
  25. Li, 1998, Neuronal differentiation of precursors in the neocortical ventricular zone is triggered by BMP, J. Neurosci, 18, 8853, 10.1523/JNEUROSCI.18-21-08853.1998 · DOI
  26. Lu, 2000, Sonic hedgehog—regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system, Neuron, 25, 317, 10.1016/S0896-6273(00)80897-1 · DOI
  27. Luskin, 1988, Cell lineage in the cerebral cortex of the mouse studied in vivo and in vitro with a recombinant retrovirus, Neuron, 1, 635, 10.1016/0896-6273(88)90163-8 · DOI
  28. Ma, 1996, Identification of neurogenin, a vertebrate neuronal determination gene, Cell, 87, 43, 10.1016/S0092-8674(00)81321-5 · DOI
  29. Ma, 1997, Mash1 and neurogenin1 expression patterns define complementary domains of neuroepithelium in the developing CNS and are correlated with regions expressing notch ligands, J. Neurosci, 17, 3644, 10.1523/JNEUROSCI.17-10-03644.1997 · DOI
  30. Mabie, 1999, Multiple roles of bone morphogenetic protein signaling in the regulation of cortical cell number and phenotype, J. Neurosci, 19, 7077, 10.1523/JNEUROSCI.19-16-07077.1999 · DOI
  31. Massague, 1998, TGF-beta signal transduction, Annu. Rev. Biochem, 67, 753, 10.1146/annurev.biochem.67.1.753 · DOI
  32. Morrison, 2000, Transient Notch activation initiates an irreversible switch from neurogenesis to gliogenesis by neural crest stem cells, Cell, 101, 499, 10.1016/S0092-8674(00)80860-0 · DOI
  33. Nakashima, 1999, Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300, Science, 284, 479, 10.1126/science.284.5413.479 · DOI
  34. Nieto, 2001, Neural bHLH genes control the neuronal versus glial fate decision in cortical progenitors, Neuron, 29, 10.1016/S0896-6273(01)00214-8 · DOI
  35. Park, 1999, Bipotent cortical progenitor cells process conflicting cues for neurons and glia in a hierarchical manner, J. Neurosci, 19, 10383, 10.1523/JNEUROSCI.19-23-10383.1999 · DOI
  36. Peyton, 1994, Two distinct class A helix-loop-helix transcription factors, E2A and BETA1, form separate DNA binding complexes on the insulin gene E box, J. Biol. Chem, 269, 25936, 10.1016/S0021-9258(18)47336-X · DOI
  37. Price, 1988, Cell lineage in the rat cerebral cortex, Development, 104, 473, 10.1242/dev.104.3.473 · DOI
  38. Qian, 2000, Timing of CNS cell generation, Neuron, 28, 69, 10.1016/S0896-6273(00)00086-6 · DOI
  39. Rajan, 1998, Multiple routes to astrocytic differentiation in the CNS, J. Neurosci, 18, 3620, 10.1523/JNEUROSCI.18-10-03620.1998 · DOI
  40. Scully, 2000, Allosteric effects of pit-1 DNA sites on long-term repression in cell type specification, Science, 290, 1127, 10.1126/science.290.5494.1127 · DOI
  41. Shah, 1997, Integration of multiple instructive cues by neural crest stem cells reveals cell-intrinsic biases in relative growth factor responsiveness, Proc. Natl. Acad. Sci. USA, 94, 11369, 10.1073/pnas.94.21.11369 · DOI
  42. Sommer, 1996, Neurogenins, a novel family of atonal-related bHLH transcription factors, are putative mammalian neuronal determination genes that reveal progenitor cell heterogeneity in the developing CNS and PNS, Mol. Cell. Neurosci, 8, 221, 10.1006/mcne.1996.0060 · DOI
  43. Stahl, 1994, The tripartite CNTF receptor complex, J. Neurobiol, 25, 1454, 10.1002/neu.480251111 · DOI
  44. Tajbakhsh, 1996, Muscle progenitor cells failing to respond to positional cues adopt non-myogenic fates in myf-5 null mice, Nature, 384, 266, 10.1038/384266a0 · DOI
  45. Tomita, 2000, Mammalian achaete-scute and atonal homologs regulate neuronal versus glial fate determination in the central nervous system, EMBO J, 19, 5460, 10.1093/emboj/19.20.5460 · DOI
  46. Turner, 1987, A common progenitor for neurons and glia persists in rat retina late in development, Nature, 328, 131, 10.1038/328131a0 · DOI
  47. Williams, 1997, A PDGF-regulated immediate early gene response initiates neuronal differentiation in ventricular zone progenitor cells, Neuron, 18, 553, 10.1016/S0896-6273(00)80297-4 · DOI
  48. Zhou, 2000, Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors, Neuron, 25, 331, 10.1016/S0896-6273(00)80898-3 · DOI · Paper page

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Metadata

Authors
Sun, Y., Nadal-Vicens, M., Misono, S., Lin, M. Z., Zubiaga, A., Hua, X., Fan, G., & Greenberg, M. E.
Venue
Cell
Publisher
Elsevier BV
Published
2001-02
Volume
104
Issue
3
Pages
365-376
ISSN
0092-8674
DOI
10.1016/s0092-8674(01)00224-0
Cited by
681
References
2
Language
en
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