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B-Cell Maturation Protein, Which Binds the Tumor Necrosis Factor Family Members BAFF and APRIL, Is Dispensable for Humoral Immune Responses
Open accessAbstract
B-cell maturation protein (BCMA) is a member of the tumor necrosis factor (TNF) receptor family and is expressed in B lymphocytes. BCMA binds two TNF family members, BAFF and APRIL, that stimulate cellular proliferation. BAFF in particular has been shown to influence B-cell survival and activation, and transgenic mice overexpressing BAFF have a lupus-like autoimmune disorder. We have inactivated BCMA in the mouse germ line. BCMA(-/-) mice have normal B-cell development, and the life span of mutant B lymphocytes is comparable to that of wild-type B cells. The humoral immune responses of BCMA(-/-) mice to T-cell-independent antigens as well as high and low doses of T-cell-dependent antigens are also intact. In addition, mutant mice have normal splenic architecture, and germinal centers are formed during an ongoing immune response. These data suggest a functional redundancy of BCMA in B-cell physiology that is probably due to the presence of TACI, another TNF receptor family member that is expressed on B cells and that can also bind BAFF and APRIL.
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Cited by
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Aggarwal, B. B., Shishodia, S., Sandur, S. K., Pandey, M. K., & Sethi, G. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.06.029 · Cited by 1,312
An Essential Role for BAFF in the Normal Development of B Cells Through a BCMA-Independent Pathway
Schiemann, B., Gommerman, J. L., Vora, K., Cachero, T. G., Shulga-Morskaya, S., Dobles, M., Frew, E., & Scott, M. L. (2001) · Science · doi:10.1126/science.1061964 · Cited by 1,069
BAFF-R, a Newly Identified TNF Receptor That Specifically Interacts with BAFF
Thompson, J. S., Bixler, S. A., Qian, F., Vora, K., Scott, M. L., Cachero, T. G., Hession, C., Schneider, P., Sizing, I. D., Mullen, C., et al. (2001) · Science · doi:10.1126/science.1061965 · Cited by 889
BAFF: A fundamental survival factor for B cells
Mackay, F., & Browning, J. L. (2002) · Nature Reviews Immunology · doi:10.1038/nri844 · Cited by 743
Reduced Competitiveness of Autoantigen-Engaged B Cells due to Increased Dependence on BAFF
Lesley, R., Xu, Y., Kalled, S. L., Hess, D. M., Schwab, S. R., Shu, H.-B., & Cyster, J. G. (2004) · Immunity · doi:10.1016/s1074-7613(04)00079-2 · Cited by 577
Metadata
- Authors
- Xu, S., & Lam, K.-P.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2001-06-01
- Volume
- 21
- Issue
- 12
- Pages
- 4067-4074
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2104199439
- Cited by
- 267
- References
- 0
- FWCI
- 7.73
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: B-Cell Maturation Protein, Which Binds the Tumor Necrosis Factor Family Members BAFF and APRIL, Is Dispensable for Humoral Immune Responses. https://app.cochat.ai/papers/10.1128/mcb.21.12.4067-4074.2001
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- Xu, S., & Lam, K.-P. (2001). B-Cell Maturation Protein, Which Binds the Tumor Necrosis Factor Family Members BAFF and APRIL, Is Dispensable for Humoral Immune Responses. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.21.12.4067-4074.2001
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