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An Essential Role for BAFF in the Normal Development of B Cells Through a BCMA-Independent Pathway
Abstract
The B cell activating factor BAFF (BlyS/TALL-1/zTNF4) is a tumor necrosis factor (TNF)–related ligand that promotes B cell survival and binds to three receptors (BCMA, TACI, and the recently described BAFF-R). Here we report an absolute requirement for BAFF in normal B cell development. Examination of secondary lymphoid organs from BAFF-deficient mice revealed an almost complete loss of follicular and marginal zone B lymphocytes. In contrast, mice lacking BCMA had normal-appearing B lymphocyte compartments. BAFF therefore plays a crucial role in B cell development and can function through receptors other than BCMA.
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Metadata
- Authors
- Schiemann, B., Gommerman, J. L., Vora, K., Cachero, T. G., Shulga-Morskaya, S., Dobles, M., Frew, E., & Scott, M. L.
- Venue
- Science
- Published
- 2001-09-14
- Volume
- 293
- Issue
- 5537
- Pages
- 2111-2114
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2012751406
- Cited by
- 1,069
- References
- 0
- FWCI
- 18.97
- Type
- journal article
- Language
- en
- Open access
- closed
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- Schiemann, B., Gommerman, J. L., Vora, K., Cachero, T. G., Shulga-Morskaya, S., Dobles, M., Frew, E., & Scott, M. L. (2001). An Essential Role for BAFF in the Normal Development of B Cells Through a BCMA-Independent Pathway. Science. https://doi.org/10.1126/science.1061964
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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