The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
The Ornithine Decarboxylase Gene Is Essential for Cell Survival during Early Murine Development
Open accessAbstract
Overexpression and inhibitor studies have suggested that the c-Myc target gene for ornithine decarboxylase (ODC), the enzyme which converts ornithine to putrescine, plays an important role in diverse biological processes, including cell growth, differentiation, transformation, and apoptosis. To explore the physiological function of ODC in mammalian development, we generated mice harboring a disrupted ODC gene. ODC-heterozygous mice were viable, normal, and fertile. Although zygotic ODC is expressed throughout the embryo prior to implantation, loss of ODC did not block normal development to the blastocyst stage. Embryonic day E3.5 ODC-deficient embryos were capable of uterine implantation and induced maternal decidualization yet failed to develop substantially thereafter. Surprisingly, analysis of ODC-deficient blastocysts suggests that loss of ODC does not affect cell growth per se but rather is required for survival of the pluripotent cells of the inner cell mass. Therefore, ODC plays an essential role in murine development, and proper homeostasis of polyamine pools appears to be required for cell survival prior to gastrulation.
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Cites
Okano, M., Bell, D. W., Haber, D. A., & Li, E. (1999) · Cell · doi:10.1016/s0092-8674(00)81656-6 · Cited by 6,143
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
Li, E., Bestor, T. H., & Jaenisch, R. (1992) · Cell · doi:10.1016/0092-8674(92)90611-f · Cited by 3,984
Early Embryonic Lethality Caused by Targeted Disruption of the Mouse Thioredoxin Gene
Matsui, M., Oshima, M., Oshima, H., Takaku, K., Maruyama, T., Yodoi, J., & Taketo, M. M. (1996) · Developmental Biology · doi:10.1006/dbio.1996.0208 · Cited by 546 · cited 2×
“The knockouts of two other Myc targets, Cul1 and H-ferritin, also result in embryonic lethal phenotypes, although the lethalities appear to occur somewhat later (12, 16, 52).”
Background
Cited by
Polyamines and cancer: old molecules, new understanding
Gerner, E. W., & Meyskens, F. L. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1454 · Cited by 1,159
Modulation of cellular function by polyamines
Igarashi, K., & Kashiwagi, K. (2010) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2009.07.009 · Cited by 851
Functions of Polyamines in Mammals
Pegg, A. E. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.r116.731661 · Cited by 718
Polyamines and cancer: implications for chemotherapy and chemoprevention
Nowotarski, S. L., Woster, P. M., & Casero, R. A. (2013) · Expert Reviews in Molecular Medicine · doi:10.1017/erm.2013.3 · Cited by 305
Stress management in aquaculture: a review of dietary interventions
Ciji, A., & Akhtar, M. S. (2021) · Reviews in Aquaculture · doi:10.1111/raq.12565 · Cited by 265
Metadata
- Authors
- Pendeville, H., Carpino, N., Marine, J.-C., Takahashi, Y., Muller, M., Martial, J. A., & Cleveland, J. L.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2001-10-01
- Volume
- 21
- Issue
- 19
- Pages
- 6549-6558
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2167740392
- Cited by
- 262
- References
- 3
- FWCI
- 2.17
- Type
- journal article
- Language
- en
- Open access
- green
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- Pendeville, H., Carpino, N., Marine, J.-C., Takahashi, Y., Muller, M., Martial, J. A., & Cleveland, J. L. (2001). The Ornithine Decarboxylase Gene Is Essential for Cell Survival during Early Murine Development. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.21.19.6549-6558.2001
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