The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Identification of Components of the Murine Histone Deacetylase 6 Complex: Link between Acetylation and Ubiquitination Signaling Pathways
Open accessAbstract
The immunopurification of the endogenous cytoplasmic murine histone deacetylase 6 (mHDAC6), a member of the class II HDACs, from mouse testis cytosolic extracts allowed the identification of two associated proteins. Both were mammalian homologues of yeast proteins known to interact with each other and involved in the ubiquitin signaling pathway: p97/VCP/Cdc48p, a homologue of yeast Cdc48p, and phospholipase A2-activating protein, a homologue of yeast UFD3 (ubiquitin fusion degradation protein 3). Moreover, in the C-terminal region of mHDAC6, a conserved zinc finger-containing domain named ZnF-UBP, also present in several ubiquitin-specific proteases, was discovered and was shown to mediate the specific binding of ubiquitin by mHDAC6. By using a ubiquitin pull-down approach, nine major ubiquitin-binding proteins were identified in mouse testis cytosolic extracts, and mHDAC6 was found to be one of them. All of these findings strongly suggest that mHDAC6 could be involved in the control of protein ubiquitination. The investigation of biochemical properties of the mHDAC6 complex in vitro further supported this hypothesis and clearly established a link between protein acetylation and protein ubiquitination.
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“HDAC6 also regulates the autophagy-dependent clearance of defective mitochondria (Seigneurin-Berny et al., 2001), likely compromising lipid metabolism in Abca4−/− mice (discussed in more detail section 6).”
From The cell biology of the retinal pigment epithelium (2020) · cites this paper as Seigneurin-Berny et al., 2001
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Cites
SMART, a simple modular architecture research tool: Identification of signaling domains
Schultz, J., Milpetz, F., Peer Bork, B., & Ponting, C. P. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.5857 · Cited by 3,577
UBIQUITIN-DEPENDENT PROTEIN DEGRADATION
Hochstrasser, M. (1996) · Annual Review of Genetics · doi:10.1146/annurev.genet.30.1.405 · Cited by 1,706
Spermatogenic cells of the prepuberal mouse: isolation and morphological characterization
Bellve, A., Cavicchia, J. C., Millette, C. F., O'Brien, D. A., Bhatnagar, Y. M., & Dym, M. (1977) · The Journal of Cell Biology · doi:10.1083/jcb.74.1.68 · Cited by 1,386
A Novel Ubiquitination Factor, E4, Is Involved in Multiubiquitin Chain Assembly
Koegl, M., Hoppe, T., Schlenker, S., Ulrich, H. D., Mayer, T. U., & Jentsch, S. (1999) · Cell · doi:10.1016/s0092-8674(00)80574-7 · Cited by 1,074
A Proteolytic Pathway That Recognizes Ubiquitin as a Degradation Signal
Johnson, E. S., Philip, C. M., Ota, I. M., & Varshavsky, A. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.29.17442 · Cited by 830
Regulation of E2F1 activity by acetylation
Martínez‐Balbás, M. A., Bauer, U., Nielsen, S. J., Brehm, A., & Kouzarides, T. (2000) · The EMBO Journal · doi:10.1093/emboj/19.4.662 · Cited by 670
Huibregtse, J. M., Scheffner, M., & Howley, P. M. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.2.775 · Cited by 553
The Human Histone Deacetylase Family
Gray, S. G., & Ekström, T. J. (2001) · Experimental Cell Research · doi:10.1006/excr.2000.5080 · Cited by 544
The AAA team: related ATPases with diverse functions
Patel, S. (1998) · Trends in Cell Biology · doi:10.1016/s0962-8924(97)01212-9 · Cited by 519
Separation of mouse spermatogenic cells by sedimentation velocity
Romrell, L. J., Bellvé, A. R., & Fawcett, D. W. (1976) · Developmental Biology · doi:10.1016/0012-1606(76)90262-1 · Cited by 502
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Hubbert, C., Guardiola, A., Shao, R., Kawaguchi, Y., Ito, A., Nixon, A., Yoshida, M., Wang, X.-F., & Yao, T.-P. (2002) · Nature · doi:10.1038/417455a · Cited by 2,403
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Minucci, S., & Pelicci, P. G. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1779 · Cited by 2,234
Kawaguchi, Y., Kovacs, J. J., McLaurin, A. C., Vance, J. M., Ito, A., & Yao, T. (2003) · Cell · doi:10.1016/s0092-8674(03)00939-5 · Cited by 1,529
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Metadata
- Authors
- Seigneurin-Berny, D., Verdel, A., Curtet, S., Lemercier, C., Garin, J., Rousseaux, S., & Khochbin, S.
- Affiliations
- Laboratoire de Biologie Moléculaire et Cellulaire de la Différenciation, INSERM U309, Equipe Chromatine et Expression des Gènes, Institut Albert Bonniot, Facultéde Médecine, Domaine de la Merci
- Inserm (FR)
- Laboratoire de Chimie des Protéines, CEA
- Corresponding author
- Khochbin, Saadi
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2001-12
- Volume
- 21
- Issue
- 23
- Pages
- 8035-8044
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- PMC
- PMC99970
- OpenAlex
- W2125568224
- Cited by
- 335
- References
- 38
- Citations by year
- 2026: 8 · 2025: 5 · 2024: 6 · 2023: 10 · 2022: 8 · 2021: 11 · 2020: 14 · 2019: 9 · 2018: 15 · 2017: 17 · 2016: 12 · 2015: 9 · 2014: 15 · 2013: 16 · 2012: 15
- FWCI
- 5.36
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Molecular and Cellular Biology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- HAL (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Histone Deacetylase Inhibitors Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- HDAC6, class II HDACs, protein acetylation, ubiquitination, ubiquitin-binding protein, ubiquitin-specific protease, protein degradation
- MeSH terms
- Histone Deacetylase 6, Valosin Containing Protein, Acetylation, Adenosine Triphosphatases, Animals, Enzyme Activation, Histone Deacetylases, Male, Molecular Sequence Data, Endopeptidases, Protein Binding, Proteins, Spermatogenesis, Testis, Ubiquitins, Signal Transduction, Zinc Fingers, Sequence Homology, Amino Acid, Protein Structure, Tertiary, Cell Cycle Proteins, Macromolecular Substances, Mice, Ubiquitin-Specific Proteases
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