Identification of Components of the Murine Histone Deacetylase 6 Complex: Link between Acetylation and Ubiquitination Signaling Pathways

SMART, a simple modular architecture research tool: Identification of signaling domains

Schultz, J., Milpetz, F., Peer Bork, B., & Ponting, C. P. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.5857 · Cited by 3,577

UBIQUITIN-DEPENDENT PROTEIN DEGRADATION

Hochstrasser, M. (1996) · Annual Review of Genetics · doi:10.1146/annurev.genet.30.1.405 · Cited by 1,706

Spermatogenic cells of the prepuberal mouse: isolation and morphological characterization

Bellve, A., Cavicchia, J. C., Millette, C. F., O'Brien, D. A., Bhatnagar, Y. M., & Dym, M. (1977) · The Journal of Cell Biology · doi:10.1083/jcb.74.1.68 · Cited by 1,386

A Novel Ubiquitination Factor, E4, Is Involved in Multiubiquitin Chain Assembly

Koegl, M., Hoppe, T., Schlenker, S., Ulrich, H. D., Mayer, T. U., & Jentsch, S. (1999) · Cell · doi:10.1016/s0092-8674(00)80574-7 · Cited by 1,074

A Proteolytic Pathway That Recognizes Ubiquitin as a Degradation Signal

Johnson, E. S., Philip, C. M., Ota, I. M., & Varshavsky, A. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.29.17442 · Cited by 830

Regulation of E2F1 activity by acetylation

Martínez‐Balbás, M. A., Bauer, U., Nielsen, S. J., Brehm, A., & Kouzarides, T. (2000) · The EMBO Journal · doi:10.1093/emboj/19.4.662 · Cited by 670

Cloning and Expression of the cDNA for E6-AP, a Protein that Mediates the Interaction of the Human Papillomavirus E6 Oncoprotein with p53

Huibregtse, J. M., Scheffner, M., & Howley, P. M. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.2.775 · Cited by 553

The Human Histone Deacetylase Family

Gray, S. G., & Ekström, T. J. (2001) · Experimental Cell Research · doi:10.1006/excr.2000.5080 · Cited by 544

The AAA team: related ATPases with diverse functions

Patel, S. (1998) · Trends in Cell Biology · doi:10.1016/s0962-8924(97)01212-9 · Cited by 519

Separation of mouse spermatogenic cells by sedimentation velocity

Romrell, L. J., Bellvé, A. R., & Fawcett, D. W. (1976) · Developmental Biology · doi:10.1016/0012-1606(76)90262-1 · Cited by 502

HDAC6 is a microtubule-associated deacetylase

Hubbert, C., Guardiola, A., Shao, R., Kawaguchi, Y., Ito, A., Nixon, A., Yoshida, M., Wang, X.-F., & Yao, T.-P. (2002) · Nature · doi:10.1038/417455a · Cited by 2,403

Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer

Minucci, S., & Pelicci, P. G. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1779 · Cited by 2,234

The Deacetylase HDAC6 Regulates Aggresome Formation and Cell Viability in Response to Misfolded Protein Stress

Kawaguchi, Y., Kovacs, J. J., McLaurin, A. C., Vance, J. M., Ito, A., & Yao, T. (2003) · Cell · doi:10.1016/s0092-8674(03)00939-5 · Cited by 1,529

The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men

Yang, X., & Seto, E. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2346 · Cited by 1,277

Proteasomal and Autophagic Degradation Systems

Đikić, I. (2017) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-061516-044908 · Cited by 1,217

TAB2 and TAB3 Activate the NF-κB Pathway through Binding to Polyubiquitin Chains

Kanayama, A., Seth, R. B., Sun, L., Ea, C.-K., Hong, M., Shaito, A. A., Chiu, Y., Deng, L., & Chen, Z. J. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.08.008 · Cited by 911

Ubiquitin-binding domains

Hicke, L., Schubert, H., & Hill, C. P. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1701 · Cited by 795

Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation

Dompierre, J. P., Godin, J. D., Charrin, B. C., Cordelières, F. P., King, S. J., Humbert, S., & Saudou, F. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.0037-07.2007 · Cited by 792

HDAC6 controls autophagosome maturation essential for ubiquitin‐selective quality‐control autophagy

Lee, J., Koga, H., Kawaguchi, Y., Tang, W., Wong, E., Gao, Y., Pandey, U. B., Kaushik, S., Tresse, E., Lu, J., et al. (2010) · The EMBO Journal · doi:10.1038/emboj.2009.405 · Cited by 756

HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo

Zhang, Y., Li, N., Caron, C., Matthias, G., Hess, D., Khochbin, S., & Matthias, P. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg115 · Cited by 740

HDAC6 Modulates Cell Motility by Altering the Acetylation Level of Cortactin

Zhang, X. M., Yuan, Z., Zhang, Y., Yong, S., Salas-Burgos, A., Koomen, J. M., Olashaw, N., Parsons, J. T., Yang, X., Dent, S., et al. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.05.033 · Cited by 731

HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin.

Iwata, A., Riley, B. E., Johnston, J. A., & Kopito, R. R. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508786200 · Cited by 719

In vivo destabilization of dynamic microtubules by HDAC6‐mediated deacetylation

Matsuyama, A., Shimazu, T., Sumida, Y., Saito, A., Yoshimatsu, Y., Seigneurin‐Berny, D., Osada, H., Komatsu, Y., Nishino, N., Khochbin, S., et al. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf682 · Cited by 720

Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis.

Bienko, M., Green, C. M., Crosetto, N., Rudolf, F., Zapart, G., Coull, B., Kannouche, P., Wider, G., Peter, M., Lehmann, A. R., et al. (2005) · Science · doi:10.1126/science.1120615 · Cited by 712

Class II histone deacetylases: versatile regulators

Verdin, E., Dequiedt, F., & Kasler, H. G. (2003) · Trends in Genetics · doi:10.1016/s0168-9525(03)00073-8 · Cited by 664

Functional Analysis of the RING-Type Ubiquitin Ligase Family of Arabidopsi s

Stone, S. L., Hauksdóttir, H., Troy, A., Herschleb, J., Kraft, E., & Callis, J. (2005) · PLANT PHYSIOLOGY · doi:10.1104/pp.104.052423 · Cited by 623

Ubiquitin-binding domains

Hurley, J. H., Lee, S., & Prag, G. (2006) · Biochemical Journal · doi:10.1042/bj20061138 · Cited by 614

Mice Lacking Histone Deacetylase 6 Have Hyperacetylated Tubulin but Are Viable and Develop Normally

Zhang, Y., Kwon, S., Yamaguchi, T., Cubizolles, F., Rousseaux, S., Kneissel, M., Cao, C., Li, N., Cheng, H.-L., Chua, K., et al. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01154-06 · Cited by 559

HDAC6: a key regulator of cytoskeleton, cell migration and cell–cell interactions

Valenzuela-Fernández, A., Cabrero, J. R., Serrador, J. M., & Sánchez‐Madrid, F. (2008) · Trends in Cell Biology · doi:10.1016/j.tcb.2008.04.003 · Cited by 510

COI1 links jasmonate signalling and fertility to the SCF ubiquitin–ligase complex in Arabidopsis

Devoto, A., Nieto‐Rostro, M., Xie, D., Ellis, C., Harmston, R., Patrick, E. H., Davis, J., Sherratt, L., Coleman, M. J., & Turner, J. G. (2002) · The Plant Journal · doi:10.1046/j.1365-313x.2002.01432.x · Cited by 458

p300 Transcriptional Repression Is Mediated by SUMO Modification

Girdwood, D., Bumpass, D. C., Vaughan, O. A., Thain, A., Anderson, L. A., Snowden, A. W., Garcia-Wilson, E., Perkins, N. D., & Hay, R. T. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00141-2 · Cited by 448

Non-traditional Functions of Ubiquitin and Ubiquitin-binding Proteins

Schnell, J. D., & Hicke, L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.r300018200 · Cited by 442

VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD

Tresse, E., Salomons, F. A., Vesa, J., Bott, L. C., Kimonis, V., Yao, T.-P., Dantuma, N. P., & Taylor, J. P. (2010) · Autophagy · doi:10.4161/auto.6.2.11014 · Cited by 437

Histone Deacetylases (HDACs): Evolution, Specificity, Role in Transcriptional Complexes, and Pharmacological Actionability

Milazzo, G., Mercatelli, D., Muzio, G. D., Triboli, L., Rosa, P. D., Perini, G., & Giorgi, F. M. (2020) · Genes · doi:10.3390/genes11050556 · Cited by 448

Transcriptional regulation by histone ubiquitination and deubiquitinationPreprint

Zhang, Y. (2003) · Genes & Development · doi:10.1101/gad.1156403 · Cited by 425

Class II Histone Deacetylases: from Sequence to Function, Regulation, and Clinical Implication

Yang, X., & Grégoire, S. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.8.2873-2884.2005 · Cited by 428

The cell biology of the retinal pigment epithelium

Lakkaraju, A., Umapathy, A., Tan, L. X., Daniele, L., Philp, N. J., Boesze-Battaglia, K., & Williams, D. S. (2020) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2020.100846 · Cited by 422

The deacetylase HDAC6 is a novel critical component of stress granules involved in the stress responsePreprint

Kwon, S., Zhang, Y., & Matthias, P. (2007) · Genes & Development · doi:10.1101/gad.461107 · Cited by 417

HDAC6, at the crossroads between cytoskeleton and cell signaling by acetylation and ubiquitination

Boyault, C., Sadoul, K., Pabion, M., & Khochbin, S. (2007) · Oncogene · doi:10.1038/sj.onc.1210614 · Cited by 397

Histone deacetylase 6 interacts with the microtubule‐associated protein tau

Ding, H., Dolan, P. J., & Johnson, G. V. W. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05564.x · Cited by 387

Protein aggregates in Huntington's disease

Arrasate, M., & Finkbeiner, S. M. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.12.013 · Cited by 407

Control of Smad7 Stability by Competition between Acetylation and Ubiquitination

Gronroos, E. C., Hellman, U., Heldin, C., & Ericsson, J. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00639-1 · Cited by 383

The Role of HDAC6 in Cancer

Aldana-Masangkay, G. I., & Sakamoto, K. M. (2010) · BioMed Research International · doi:10.1155/2011/875824 · Cited by 388

HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregatesPreprint

Boyault, C., Zhang, Y., Fritah, S., Caron, C., Gilquin, B., Kwon, S. H., Garrido, C., Yao, T., Vourc’h, C., Matthias, P., et al. (2007) · Genes & Development · doi:10.1101/gad.436407 · Cited by 387

Direct binding of ubiquitin conjugates by the mammalian p97 adaptor complexes, p47 and Ufd1–Npl4

Meyer, H. H., Wang, Y., & Warren, G. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf579 · Cited by 363

The Roles of Histone Deacetylases and Their Inhibitors in Cancer Therapy

Guo, L., Tian, Y., & Zhu, W. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.576946 · Cited by 364

Histone deacetylase 6 plays a role as a distinct regulator of diverse cellular processes

Li, Y., Shin, D., & Kwon, S. H. (2012) · FEBS Journal · doi:10.1111/febs.12079 · Cited by 351

HDAC6 as a target for neurodegenerative diseases: what makes it different from the other HDACs?

Simões-Pires, C., Zwick, V., Nurisso, A., Schenker, E., Carrupt, P.-A., & Cuendet, M. (2013) · Molecular Neurodegeneration · doi:10.1186/1750-1326-8-7 · Cited by 341

The Ubiquitin Binding Domain ZnF UBP Recognizes the C-Terminal Diglycine Motif of Unanchored Ubiquitin

Reyes‐Turcu, F. E., Horton, J. R., Mullally, J. E., Heroux, A., Cheng, X., & Wilkinson, K. D. (2006) · Cell · doi:10.1016/j.cell.2006.02.038 · Cited by 348

Aggresome induction by proteasome inhibitor bortezomib and α-tubulin hyperacetylation by tubulin deacetylase (TDAC) inhibitor LBH589 are synergistic in myeloma cells

Catley, L. P., Weisberg, E., Kiziltepe, T., Tai, Y., Hideshima, T., Neri, P., Tassone, P., Atadja, P. W., Chauhan, D., Munshi, N. C., et al. (2006) · Blood · doi:10.1182/blood-2006-04-016055 · Cited by 336

Runx2 (Cbfa1, AML-3) Interacts with Histone Deacetylase 6 and Represses the p21 CIP1/WAF1 Promoter

Westendorf, J. J., Zaidi, S. K., Cascino, J. E., Kahler, R. A., van Wijnen, A. J., Lian, J. B., Yoshida, M., Stein, G. S., & Li, X. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.22.7982-7992.2002 · Cited by 319

Histone Deacetylases Inhibitors in Neurodegenerative Diseases, Neuroprotection and Neuronal Differentiation

Shukla, S., & Tekwani, B. L. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00537 · Cited by 314

Regulatory cross-talk between lysine acetylation and ubiquitination: role in the control of protein stability

Caron, C., Boyault, C., & Khochbin, S. (2005) · BioEssays · doi:10.1002/bies.20210 · Cited by 292

The functional interactome landscape of the human histone deacetylase family

Joshi, P., Greco, T. M., Guise, A. J., Luo, Y., Yu, F., Nesvizhskii, A. I., & Cristea, I. M. (2013) · Molecular Systems Biology · doi:10.1038/msb.2013.26 · Cited by 289

Influenza A virus uses the aggresome processing machinery for host cell entry

Banerjee, I., Miyake, Y., Nobs, S. P., Schneider, C., Horváth, P., Köpf, M., Matthias, P., Helenius, A., & Yamauchi, Y. (2014) · Science · doi:10.1126/science.1257037 · Cited by 285

Regulation of Jasmonate-mediated Plant Responses in Arabidopsis

Devoto, A. (2003) · Annals of Botany · doi:10.1093/aob/mcg151 · Cited by 281

HDAC6–p97/VCP controlled polyubiquitin chain turnover

Boyault, C., Gilquin, B., Zhang, Y., Rybin, V., Garman, E. F., Meyer‐Klaucke, W., Matthias, P., Müller, C. W., & Khochbin, S. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601210 · Cited by 280

Tubulin acetylation: responsible enzymes, biological functions and human diseases

Li, L., & Yang, X. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2000-5 · Cited by 264

Mitochondrial dysfunction and mitophagy: the beginning and end to diabetic nephropathy?

Higgins, G. C., & Coughlan, M. T. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12503 · Cited by 257

Collaborative spirit of histone deacetylases in regulating chromatin structure and gene expression

Yang, X., & Seto, E. (2003) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(03)00015-7 · Cited by 245

Protein oxidation in aging and the removal of oxidized proteins

Höhn, A., König, J., & Grune, T. (2013) · Journal of Proteomics · doi:10.1016/j.jprot.2013.01.004 · Cited by 253

Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases

Quesada, V., Díaz‐Perales, A., Gutiérrez‐Fernández, A., Garabaya, C., Cal, S., & López-Otı́n, C. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.12.050 · Cited by 235

A novel Rho-mDia2-HDAC6 pathway controls podosome patterning through microtubule acetylation in osteoclasts

Destaing, O., Saltel, F., Gilquin, B., Chabadel, A., Khochbin, S., Ory, S., & Jurdic, P. (2005) · Journal of Cell Science · doi:10.1242/jcs.02425 · Cited by 244

Coactivator-Dependent Acetylation Stabilizes Members of the SREBP Family of Transcription Factors

Giandomenico, V., Simonsson, M., Grünroos, E., & Ericsson, J. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.7.2587-2599.2003 · Cited by 205

Histone deacetylase 6 binds polyubiquitin through its zinc finger (PAZ domain) and copurifies with deubiquitinating enzymes

Hook, S. S., Orian, A., Cowley, S. M., & Eisenman, R. N. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.172511699 · Cited by 229

Aggresome Formation and Neurodegenerative Diseases: Therapeutic Implications

Chin, L., Olzmann, J. A., & Li, L. (2008) · Current Medicinal Chemistry · doi:10.2174/092986708783330692 · Cited by 233

Regulation of protein turnover by acetyltransferases and deacetylases

Sadoul, K., Boyault, C., Pabion, M., & Khochbin, S. (2007) · Biochimie · doi:10.1016/j.biochi.2007.06.009 · Cited by 222

Histone Deacetylase 6 in Health and Disease

Seidel, C., Schnekenburger, M., Dicato, M. A., & Diederich, M. F. (2015) · Epigenomics · doi:10.2217/epi.14.69 · Cited by 219

Invited Review: Exercise training-induced changes in insulin signaling in skeletal muscle

Zierath, J. R. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00126.2002 · Cited by 215

Histone deacetylase inhibitors as therapeutics for polyglutamine disorders

Butler, R. K., & Bates, G. P. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1989 · Cited by 215

Transforming Growth Factor-β Stimulates p300-dependent RUNX3 Acetylation, Which Inhibits Ubiquitination-mediated Degradation

Jin, Y.-H., Jeon, E.-J., Li, Q.-L., Lee, Y. H., Choi, J.-K., Kim, W.-J., Lee, K.-Y., & Bae, S.-C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313120200 · Cited by 211

Histone Deacetylase 6 Regulates Growth Factor-Induced Actin Remodeling and Endocytosis

Gao, Y., Hubbert, C. C., Lu, J., Lee, Y.-S., Lee, J., & Yao, T. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00393-07 · Cited by 209

The ins and outs of tubulin acetylation: More than just a post-translational modification?

Perdiz, D., Mackeh, R., Poüs, C., & Baillet, A. (2010) · Cellular Signalling · doi:10.1016/j.cellsig.2010.10.014 · Cited by 224

Association with Class IIa Histone Deacetylases Upregulates the Sumoylation of MEF2 Transcription Factors

Grégoire, S., & Yang, X. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.6.2273-2287.2005 · Cited by 207

A Comprehensive View of the Epigenetic Landscape. Part II: Histone Post-translational Modification, Nucleosome Level, and Chromatin Regulation by ncRNAs

Sadakierska−Chudy, A., & Filip, M. (2014) · Neurotoxicity Research · doi:10.1007/s12640-014-9508-6 · Cited by 202

Class IIb HDAC6 regulates endothelial cell migration and angiogenesis by deacetylation of cortactin

Kaluza, D., Krøll, J., Gesierich, S., Yao, T., Boon, R. A., Hergenreider, E., Tjwa, M., Rössig, L., Seto, E., Augustin, H. G., et al. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.298 · Cited by 196

A Centrosomal Cdc20-APC Pathway Controls Dendrite Morphogenesis in Postmitotic Neurons

Kim, A. H., Puram, S. V., Bilimoria, P. M., Ikeuchi, Y., Keough, S., Wong, M., Rowitch, D. H., & Bonni, A. (2009) · Cell · doi:10.1016/j.cell.2008.11.050 · Cited by 190

Inhibition of autophagy, lysosome and VCP function impairs stress granule assembly

Seguin, S. J., Morelli, F. F., Vinet, J., Amore, D., Biasi, S. D., Poletti, A., Rubinsztein, D. C., & Carra, S. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.103 · Cited by 196

The Balance between Acetylation and Deacetylation Controls Smad7 Stability

Simonsson, M., Heldin, C., Ericsson, J., & Gronroos, E. C. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503134200 · Cited by 184

Parkin-mediated K63-linked polyubiquitination: A signal for targeting misfolded proteins to the aggresome-autophagy pathway

Olzmann, J. A., & Chin, L. (2008) · Autophagy · doi:10.4161/auto.5172 · Cited by 187

Histone deacetylases—an important class of cellular regulators with a variety of functions

Hildmann, C., Riester, D., & Schwienhorst, A. (2007) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-007-0911-2 · Cited by 182

Identification of HDAC10, a novel class II human histone deacetylase containing a leucine-rich domain

Tong, J. J. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.5.1114 · Cited by 181

The emerging role of acetylation in the regulation of autophagy

Bánréti, Á., Sass, M., & Graba, Y. (2013) · Autophagy · doi:10.4161/auto.23908 · Cited by 164

CYLD negatively regulates cell‐cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin

Wickström, S. A., Masoumi, K. C., Khochbin, S., Fässler, R., & Massoumi, R. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.317 · Cited by 178

Requirement of HDAC6 for Transforming Growth Factor-β1-induced Epithelial-Mesenchymal Transition

Shan, B., Yao, T., Nguyen, H. T., Zhuo, Y., Levy, D. R., Klingsberg, R. C., Tao, H., Palmer, M. L., Holder, K. N., & Lasky, J. A. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802786200 · Cited by 176

Role of ubiquitination in the regulation of plant defence against pathogens

Devoto, A., Muskett, P. R., & Shirasu, K. (2003) · Current Opinion in Plant Biology · doi:10.1016/s1369-5266(03)00060-8 · Cited by 175

SUMO and transcriptional regulation

Girdwood, D., Tatham, M. H., & Hay, R. T. (2004) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2003.12.001 · Cited by 170

Role of the Tetradecapeptide Repeat Domain of Human Histone Deacetylase 6 in Cytoplasmic Retention

Bertos, N., Gilquin, B., Chan, G. K. T., Yen, T. J., Khochbin, S., & Yang, X. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408583200 · Cited by 160

Crystal Structure of a Bacterial Class 2 Histone Deacetylase Homologue

Nielsen, T. K., Hildmann, C., Dickmanns, A., Schwienhorst, A., & Ficner, R. (2005) · Journal of Molecular Biology · doi:10.1016/j.jmb.2005.09.065 · Cited by 157

Signaling Through Monoubiquitination

Sigismund, S., Polo, S., & Fiore, P. P. D. (2004) · Current topics in microbiology and immunology · doi:10.1007/978-3-540-69494-6_6 · Cited by 156

HDAC6 Deacetylates and Ubiquitinates MSH2 to Maintain Proper Levels of MutSα

Zhang, M., Xiang, S., Joo, H.-Y., Wang, L., Williams, K. A., Liu, W., Hu, C., Tong, D., Haakenson, J., Wang, C., et al. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.04.028 · Cited by 151

Modulation of Histone Deacetylase 6 (HDAC6) Nuclear Import and Tubulin Deacetylase Activity through Acetylation

Liu, Y., Peng, L., Seto, E., Huang, S., & Qiu, Y. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.371120 · Cited by 144

Impaired Protein Aggregate Handling and Clearance Underlie the Pathogenesis of p97/VCP-associated Disease

Ju, J.-S., Miller, S., Hanson, P. I., & Weihl, C. C. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m805517200 · Cited by 140

Acetylation and phosphorylation of SRSF2 control cell fate decision in response to cisplatin

Edmond, V., Moysan, E., Khochbin, S., Matthias, P., Brambilla, C., Brambilla, E. M., Gazzéri, S., & Eymin, B. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.333 · Cited by 150

A novel ubiquitin‐binding protein ZNF216 functioning in muscle atrophy

Hishiya, A., Iemura, S., Natsume, T., Takayama, S.-I. J., Ikeda, K., & Watanabe, K. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7600945 · Cited by 142

Positive and Negative Regulation of the Innate Antiviral Response and Beta Interferon Gene Expression by Deacetylation

Nusinzon, I., & Horvath, C. M. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.8.3106-3113.2006 · Cited by 139

HDAC6 a new cellular stress surveillance factor

Matthias, P., Yoshida, M., & Khochbin, S. (2008) · Cell Cycle · doi:10.4161/cc.7.1.5186 · Cited by 143

HDAC6 α-tubulin deacetylase: A potential therapeutic target in neurodegenerative diseases

Li, G., Jiang, H., Chang, M., Xie, H., & Hu, L. (2011) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2011.02.017 · Cited by 141

H2B Ubiquitin Protease Ubp8 and Sgf11 Constitute a Discrete Functional Module within the Saccharomyces cerevisiae SAGA Complex

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