The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Dexamethasone Destabilizes Cyclooxygenase 2 mRNA by Inhibiting Mitogen-Activated Protein Kinase p38
Open accessAbstract
The stability of cyclooxygenase 2 (Cox-2) mRNA is regulated positively by proinflammatory stimuli acting through mitogen-activated protein kinase (MAPK) p38 and negatively by anti-inflammatory glucocorticoids such as dexamethasone. A tetracycline-regulated reporter system was used to investigate mechanisms of regulation of Cox-2 mRNA stability. Dexamethasone was found to destabilize beta-globin-Cox-2 reporter mRNAs by inhibiting p38. This inhibition occurred at the level of p38 itself: stabilization of reporter mRNA by a kinase upstream of p38 was blocked by dexamethasone, while stabilization by a kinase downstream of p38 was insensitive to dexamethasone. Inhibition of p38 activity by dexamethasone was observed in a variety of cell types treated with different activating stimuli. Furthermore, inhibition of p38 was antagonized by the anti-glucocorticoid RU486 and was delayed and actinomycin D sensitive, suggesting that ongoing glucocorticoid receptor-dependent transcription is required.
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AU-rich elements: characterization and importance in mRNA degradation
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Anti-inflammatory Actions of Glucocorticoids: Molecular Mechanisms
Barnes, P. J. (1998) · Clinical Science · doi:10.1042/cs0940557 · Cited by 1,591
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Cited by
Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses
Mogensen, T. H. (2009) · Clinical Microbiology Reviews · doi:10.1128/cmr.00046-08 · Cited by 3,111
De Bosscher, K., Vanden Berghe, W., & Haegeman, G. (2003) · Endocrine Reviews · doi:10.1210/er.2002-0006 · Cited by 898
The cap-to-tail guide to mRNA turnover
Wilusz, C. J., Wormington, M., & Peltz, S. W. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35067025 · Cited by 759
Regulation of cytoplasmic mRNA decay
Schoenberg, D. R., & Maquat, L. E. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3160 · Cited by 656
Mahtani, K. R., Brook, M., Dean, J. L. E., Sully, G., Saklatvala, J., & Clark, A. R. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.9.6461-6469.2001 · Cited by 448
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Metadata
- Authors
- Lasa, M., Brook, M., Saklatvala, J., & Clark, A. R.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2001-02
- Volume
- 21
- Issue
- 3
- Pages
- 771-780
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2106372965
- Cited by
- 259
- References
- 4
- FWCI
- 10.10
- Type
- journal article
- Language
- en
- Open access
- green
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- Lasa, M., Brook, M., Saklatvala, J., & Clark, A. R. (2001). Dexamethasone Destabilizes Cyclooxygenase 2 mRNA by Inhibiting Mitogen-Activated Protein Kinase p38. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.21.3.771-780.2001
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