The DOI matches its Crossref record; 88 of the 89 references it cites were found in a registry or an index.
Activation of NF-κB Is Essential for Hepatocyte Growth Factor-Mediated Proliferation and Tubulogenesis
Open accessAbstract
Hepatocyte growth factor (HGF) and its receptor, Met, regulate a number of biological functions in epithelial and nonepithelial cells, such as survival, motility, proliferation, and tubular morphogenesis. The transcription factor NF-kappaB is activated in response to a wide variety of stimuli, including growth factors, and is involved in biological responses in part overlapping with those triggered by HGF. In this work we used the liver-derived MLP29 cell line to study the possible involvement of NF-kappaB in HGF/Met signaling. HGF stimulates NF-kappaB DNA binding and transcriptional activation via the canonical IkappaB phosphorylation-degradation cycle and via the extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase cascades. Phosphatidylinositol 3-kinase is not involved in Met-mediated NF-kappaB activation. Blockage of NF-kappaB activation in MLP29 cells by forced expression of the NF-kappaB super-repressor IkappaB(alpha)2A does not interfere with HGF-induced scatter but inhibits proliferation and tubulogenesis. Surprisingly, in the same cells NF-kappaB appears to be dispensable for the antiapoptotic function of HGF.
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“HGF, a primary mitogen for hepatocytes, has also been reported to mediate its effects in part via the NFκB pathway [16].”
From Synthesis of IL-6 by Hepatocytes Is a Normal Response to Common Hepatic Stimuli (2014) · cites this paper as [16]
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Metadata
- Authors
- Müller, M., Morotti, A., & Ponzetto, C.
- Affiliations
- University of Turin (IT)
- Corresponding author
- Ponzetto, Carola
- ORCID
- Morotti, Alessandro
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2002-02-01
- Volume
- 22
- Issue
- 4
- Pages
- 1060-1072
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- PMC
- PMC134627
- OpenAlex
- W2136690190
- Cited by
- 129
- References
- 89
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 2 · 2023: 3 · 2022: 5 · 2021: 4 · 2020: 2 · 2019: 3 · 2018: 4 · 2017: 5 · 2016: 9 · 2015: 6 · 2014: 7 · 2013: 8 · 2012: 9
- FWCI
- 2.65
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Molecular and Cellular Biology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fondazione CRT
- Compagnia di San Paolo
- Centre National de la Recherche Scientifique
- Associazione Italiana per la Ricerca sul Cancro
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Keywords
- NF-κB activation, hepatocyte growth factor, c-Met, tubulogenesis, cell proliferation, ERK signaling, p38 MAPK signaling, phosphatidylinositol 3-kinase, IκBα super-repressor, cell scattering, antiapoptotic function, liver
- MeSH terms
- NF-KappaB Inhibitor alpha, Animals, Cell Division, Cell Line, Cell Movement, DNA, DNA-Binding Proteins, Gene Expression Regulation, Humans, Liver, Morphogenesis, Phosphorylation, Protein Binding, Proto-Oncogene Proteins, Transcription, Genetic, Tumor Necrosis Factor-alpha, Signal Transduction, NF-kappa B, Apoptosis, Hepatocyte Growth Factor, Protein Serine-Threonine Kinases, Proto-Oncogene Proteins c-met, I-kappa B Proteins, Mitogen-Activated Protein Kinases, Proto-Oncogene Proteins c-akt, Mice
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