Cited by 144Cancer, Hypoxia, and MetabolismErythropoietin and Anemia TreatmentKruppel-like factors research

The DOI matches its Crossref record; 54 of the 55 references it cites were found in a registry or an index.

Carboxyl-Terminal Transactivation Activity of Hypoxia-Inducible Factor 1α Is Governed by a von Hippel-Lindau Protein-Independent, Hydroxylation-Regulated Association with p300/CBP

Open access

Sang, Nianli, Fang, Jie, Srinivas, Vickram, Leshchinsky, Irene, Caro, Jaime·2002·Molecular and Cellular Biology

DOI 10.1128/mcb.22.9.2984-2992.2002PMC PMC133771

Open this paper in CoChat — free account

Abstract

Hypoxia-inducible factor 1 complex (HIF-1) plays a pivotal role in oxygen homeostasis and adaptation to hypoxia. Its function is controlled by both the protein stability and the transactivation activity of its alpha subunit, HIF-1 alpha. Hydroxylation of at least two prolyl residues in the oxygen-dependent degradation domain of HIF-1 alpha regulates its interaction with the von Hippel-Lindau protein (VHL) that targets HIF-1 alpha for ubiquitination and proteasomal degradation. Several prolyl hydroxylases have been found to specifically hydroxylate HIF-1 alpha. In this report, we investigated possible roles of VHL and hydroxylases in the regulation of the transactivation activity of the C-terminal activating domain (CAD) of HIF-1 alpha. We demonstrate that regulation of the transactivation activity of HIF-1 alpha CAD also involves hydroxylase activity but does not require functional VHL. In addition, stimulation of the CAD activity by a hydroxylase inhibitor, hypoxia, and desferrioxamine was severely blocked by the adenoviral oncoprotein E1A but not by an E1A mutant defective in targeting p300/CBP. We further demonstrate that a hydroxylase inhibitor, hypoxia, and desferrioxamine promote the functional and physical interaction between HIF-1 alpha CAD and p300/CBP in vivo. Taken together, our data provide evidence that hypoxia-regulated stabilization and transcriptional stimulation of HIF-1 alpha function are regulated through partially overlapping but distinguishable pathways.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1128/mcb.22.9.2984-2992.2002

Cites

54 of 54 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation
Jaakkola, P., Mole, D. R., Tian, Y.-M., Wilson, M. I., Gielbert, J., Gaskell, S. J., Kriegsheim, A. V., Hebestreit, H. F., Mukherji, M., Schofield, C. J., et al. (2001) · Science · doi:10.1126/science.1059796 · Cited by 5,535
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
Maxwell, P. H., Wiesener, M. S., Chang, G.-W., Clifford, S. C., Vaux, E. C., Cockman, M. E., Wykoff, C. C., Pugh, C. W., Maher, E. R., & Ratcliffe, P. J. (1999) · Nature · doi:10.1038/20459 · Cited by 5,180
HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing
Ivan, M., Kondo, K., Yang, H., Kim, W., Valiando, J., Ohh, M., Salic, A., Asara, J. M., Lane, W. S., & Kaelin Jr., W. G. (2001) · Science · doi:10.1126/science.1059817 · Cited by 4,735 · cited 2×
“The interaction between VHL and HIF-1 depends on the hydroxylation of proline residues (Pro-402 and Pro-564) in the oxygen-dependent degradation domain of HIF-1 ( 17 , 19, 29, 51).”
Background
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
Epstein, A. C. R., Gleadle, J. M., McNeill, L. A., Hewitson, K. S., O'Rourke, J., Mole, D. R., Mukherji, M., Metzen, E., Wilson, M. I., Dhanda, A., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00507-4 · Cited by 3,333
Identification of the von Hippel-Lindau Disease Tumor Suppressor Gene
Latif, F., Tory, K., Gnarra, J. R., Yao, M., Duh, F.-M. C., Orcutt, M. L., Stackhouse, T. M., Kuzmin, I., Modi, W. S., Geil, L., et al. (1993) · Science · doi:10.1126/science.8493574 · Cited by 2,971
A conserved family of prolyl-4-hydroxylases that modify HIF
Bruick, R. K., & McKnight, S. L. (2001) · Science · doi:10.1126/science.1066373 · Cited by 2,549
Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
Carmeliet, P., Dor, Y., Herbert, J.-M., Fukumura, D., Brusselmans, K., Dewerchin, M., Neeman, M., Bono, F., Abramovitch, R., Maxwell, P., et al. (1998) · Nature · doi:10.1038/28867 · Cited by 2,502
Regulation of hypoxia-inducible factor 1α is mediated by an O 2 -dependent degradation domain via the ubiquitin-proteasome pathway
Huang, L. E., Gu, J., Schau, M., & Bunn, H. F. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.14.7987 · Cited by 2,113
Purification and Characterization of Hypoxia-inducible Factor 1
Wang, G. L., & Semenza, G. L. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.3.1230 · Cited by 2,094
Hypoxia-inducible Factor 1α (HIF-1α) Protein Is Rapidly Degraded by the Ubiquitin-Proteasome System under Normoxic Conditions
Salceda, S., & Caro, J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.36.22642 · Cited by 1,674
Self-citation

Show all 55 references

Research works printed but not linked: 5

10.1016/S0021-9258(19)61441-9 · DOI
Ryan H., 2000, Cancer Res., 60, 4010
Sang N., 2002, Frontiers Biosci., 7, d407
Yang H., 2001, Cell Growth Differ., 12, 447
Zhong H., 2000, Cancer Res., 60, 1541

Sorted by citations

Hypoxia-Inducible Factor-1 (HIF-1)
Ke, Q., & Costa, M. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.027029 · Cited by 1,690
FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor
Lando, D., Peet, D. J., Gorman, J. J., Whelan, D. A., Whitelaw, M. L., & Bruick, R. K. (2002) · Genes & Development · doi:10.1101/gad.991402 · Cited by 1,550
Differential Roles of Hypoxia-Inducible Factor 1α (HIF-1α) and HIF-2α in Hypoxic Gene Regulation
Hu, C.-J., Wang, L.-Y., Chodosh, L. A., Keith, B., & Simon, M. C. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.24.9361-9374.2003 · Cited by 1,386
Role of VHL Gene Mutation in Human Cancer
Kim, W. Y., & Kaelin, W. G. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.05.061 · Cited by 955
Hypoxia-induced neutrophil survival is mediated by HIF-1α–dependent NF-κB activity
Walmsley, S. R., Print, C., Farahi, N., Peyssonnaux, C., Johnson, R. S., Cramer, T., Sobolewski, A., Condliffe, A. M., Cowburn, A. S., Johnson, N., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20040624 · Cited by 891
Molecular basis of the VHL hereditary cancer syndrome
Kaelin, W. G. (2002) · Nature Reviews Cancer · doi:10.1038/nrc885 · Cited by 865
Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family
Hewitson, K. S., McNeill, L. A., Riordan, M. V., Tian, Y.-M., Bullock, A. N., Welford, R. W., Elkins, J. M., Oldham, N. J., Bhattacharya, S., Gleadle, J. M., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200273200 · Cited by 719
Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1α-degradative pathway
Isaacs, J. S., Jung, Y.-J., Mimnaugh, E. G., Martinez, A., Cuttitta, F., & Neckers, L. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204733200 · Cited by 663
Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome
Lv, R., Liu, X., Zhang, Y., Dong, N., Wang, X., He, Y., Yue, H., & Yin, Q. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01496-3 · Cited by 555
Oxygen sensing in the hypoxic response pathway: regulation of the hypoxia-inducible transcription factorPreprint
Bruick, R. K. (2003) · Genes & Development · doi:10.1101/gad.1145503 · Cited by 446
Intracellular localisation of human HIF-1α hydroxylases:implications for oxygen sensing
Metzen, E., Berchner-Pfannschmidt, U., Stengel, P., Marxsen, J. H., Stolze, I., Klinger, M., Huang, W. Q., Wotzlaw, C., Hellwig-Bürgel, T., Jelkmann, W., et al. (2003) · Journal of Cell Science · doi:10.1242/jcs.00318 · Cited by 432
MAPK Signaling Up-regulates the Activity of Hypoxia-inducible Factors by Its Effects on p300
Sang, N., Stiehl, D. P., Bohensky, J., Leshchinsky, I., Srinivas, V., & Caro, J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209702200 · Cited by 370
Self-citation
VHL and HIF signalling in renal cell carcinogenesis
Baldewijns, M. M. L. L., van Vlodrop, I. J. H., Vermeulen, P. B., Soetekouw, P. M. M. B., van Engeland, M., & de Bruı̈ne, A. P. (2010) · The Journal of Pathology · doi:10.1002/path.2689 · Cited by 326
Sequence determinants in hypoxia-inducible factor-1α for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3
Huang, J., Zhao, Q., Mooney, S. M., & Lee, F. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206955200 · Cited by 307
Negative and positive regulation of HIF-1: A complex network
Bárdos, J. I., & Ashcroft, M. A. (2005) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2005.05.001 · Cited by 287
Differential Regulation of the Transcriptional Activities of Hypoxia-Inducible Factor 1 Alpha (HIF-1α) and HIF-2α in Stem Cells
Hu, C., Iyer, S. R., Sataur, A., Covello, K. L., Chodosh, L. A., & Simon, M. C. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.9.3514-3526.2006 · Cited by 270
Histone Deacetylase Inhibitors Induce VHL and Ubiquitin-Independent Proteasomal Degradation of Hypoxia-Inducible Factor 1α
Kong, X., Lin, Z., Liang, D., Fath, D., Sang, N., & Caro, J. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.6.2019-2028.2006 · Cited by 258
Self-citation
Control and dysregulation of redox signalling in the gastrointestinal tract
Campbell, E. L., & Colgan, S. P. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0079-5 · Cited by 267
Review: Hypoxia-Inducible Factor-1 (HIF-1): A Novel Transcription Factor in Immune Reactions
Hellwig‐Bürgel, T., Stiehl, D. P., Wagner, A. E., Metzen, E., & JELKMANN, W. E. B. (2005) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2005.25.297 · Cited by 264
The hypoxia-inducible factors: key transcriptional regulators of hypoxic responses
Bracken, C. P., Whitelaw, M. L., & Peet, D. J. (2003) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-003-2370-y · Cited by 259
Ca2+/Calmodulin Kinase-dependent Activation of Hypoxia Inducible Factor 1 Transcriptional Activity in Cells Subjected to Intermittent Hypoxia
Yuan, G., Nanduri, J., Bhasker, C. R., Semenza, G. L., & Prabhakar, N. R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407706200 · Cited by 253
Hypoxic regulation of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene family (pfkfb-1-4) expression in vivo
Minchenko, O., Opentanova, I., & Caro, J. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)01179-7 · Cited by 236
Self-citation
Cell-specific Regulation of Hypoxia-inducible Factor (HIF)-1α and HIF-2α Stabilization and Transactivation in a Graded Oxygen Environment
Bracken, C. P., Fedele, A. O., Linke, S., Balrak, W., Lisy, K., Whitelaw, M. L., & Peet, D. J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m600288200 · Cited by 222
Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases
Hirota, K., & Semenza, G. L. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.08.193 · Cited by 233
PI3K/Akt Is Required for Heat Shock Proteins to Protect Hypoxia-inducible Factor 1α from pVHL-independent Degradation
Zhou, J., Schmid, T., Frank, R., & Brüne, B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m310164200 · Cited by 231
BNIP3 plays a role in hypoxic cell death in human epithelial cells that is inhibited by growth factors EGF and IGF
Kothari, S., Cizeau, J., McMillan‐Ward, E., Israels, S. J., Bailes, M., Ens, K., Kirshenbaum, L. A., & Gibson, S. B. (2003) · Oncogene · doi:10.1038/sj.onc.1206666 · Cited by 222
HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O2 levels
Masson, N., & Ratcliffe, P. J. (2003) · Journal of Cell Science · doi:10.1242/jcs.00655 · Cited by 221
Structure of factor-inhibiting hypoxia-inducible factor 1: an asparaginyl hydroxylase involved in the hypoxic response pathway
Dann, C. E., Bruick, R. K., & Deisenhofer, J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.202614999 · Cited by 200
Activation of the hypoxia‐inducible factor pathway and stimulation of angiogenesis by application of prolyl hydroxylase inhibitors
Warnecke, C., Griethe, W., Weidemann, A., Jürgensen, J. S., Willam, C., Bachmann, S., Ivashchenko, Y., Wagner, I., Frei, U. A., Wiesener, M., et al. (2003) · The FASEB Journal · doi:10.1096/fj.02-1062fje · Cited by 201
The hypoxia signaling pathway and hypoxic adaptation in fishes
Xiao, W. (2015) · Science China Life Sciences · doi:10.1007/s11427-015-4801-z · Cited by 195
The Hypoxia-Inducible Factor 2 α N-Terminal and C-Terminal Transactivation Domains Cooperate To Promote Renal Tumorigenesis In Vivo
Yan, Q., Bartz, S., Mao, M., Li, L., & Kaelin, W. G. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01514-06 · Cited by 193
Oxygen-dependent and tissue-specific regulation of erythropoietin gene expression
Fandrey, J. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00577.2003 · Cited by 243
Strict regulation of CAIXG250/MN by HIF-1α in clear cell renal cell carcinoma
Grabmaier, K., de Weijert, M., Verhaegh, G. W. C. T., Schalken, J. A., & Oosterwijk, E. (2004) · Oncogene · doi:10.1038/sj.onc.1207764 · Cited by 188
HIFs and tumors—causes and consequences
Höpfl, G., Ogunshola, O. O., & Gassmann, M. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00538.2003 · Cited by 186
Tumor Necrosis Factor-α Causes Accumulation of a Ubiquitinated Form of Hypoxia Inducible Factor-1α through a Nuclear Factor-κB-Dependent Pathway
Zhou, J., Schmid, T., & Brüne, B. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-09-0598 · Cited by 177
Normoxic stabilization of HIF-1α drives glycolytic metabolism and regulates aggrecan gene expression in nucleus pulposus cells of the rat intervertebral disk
Agrawal, A., Guttapalli, A. N., Narayan, S., Albert, T. J., Shapiro, I. M., & Risbud, M. V. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00538.2006 · Cited by 176
The von Hippel–Lindau tumor suppressor protein: new insights into oxygen sensing and cancer
Kim, W., & Kaelin, W. G. (2003) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(02)00010-2 · Cited by 177
HIF hydroxylation and cellular oxygen sensing
Metzen, E., & Ratcliffe, P. J. (2004) · Biological Chemistry · doi:10.1515/bc.2004.016 · Cited by 175
Hypoxia-Induced Gene Expression Occurs Solely through the Action of Hypoxia-Inducible Factor 1α (HIF-1α): Role of Cytoplasmic Trapping of HIF-2α
Park, S.-K., Dadak, A. M., Haase, V. H., Fontana, L., Giaccia, A. J., & Johnson, R. S. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.14.4959-4971.2003 · Cited by 171
Central Role of Muc5ac Expression in Mucous Metaplasia and Its Regulation by Conserved 5′ Elements
Young, H. W. J., Williams, O. W., Chandra, D., Bellinghausen, L. K., Pérez, G., Suárez, A. V., Tuvim, M. J., Roy, M. G., Alexander, S., Moghaddam, S. J., et al. (2007) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2005-0460oc · Cited by 169
How oxygen makes its presence felt: Figure 1.Preprint
Kaelin, W. G. (2002) · Genes & Development · doi:10.1101/gad.1003602 · Cited by 149
Hypoxia-Inducible Factor-1 (HIF-1): A Potential Target for Intervention in Ocular Neovascular Diseases
Vadlapatla, R. K., Vadlapudi, A. D., & Mitra, A. K. (2013) · Current Drug Targets · doi:10.2174/13894501113149990015 · Cited by 148
Oxygen‐dependent regulation of hypoxia‐inducible factors by prolyl and asparaginyl hydroxylation
Lando, D., Gorman, J. J., Whitelaw, M. L., & Peet, D. J. (2003) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2003.03445.x · Cited by 138
Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth
Mack, F. A., Rathmell, W. K., Arsham, A. M., Gnarra, J., Keith, B., & Simon, M. C. (2003) · Cancer Cell · doi:10.1016/s1535-6108(02)00240-4 · Cited by 160
Hypoxia-Inducible Factor-1: A Critical Player in the Survival Strategy of Stressed Cells
Chen, S., & Sang, N. (2015) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25283 · Cited by 137
Self-citation
HIF-1 in Cell Cycle Regulation, Apoptosis, and Tumor Progression
Goda, N., Dozier, S. J., & Johnson, R. S. (2003) · Antioxidants and Redox Signaling · doi:10.1089/152308603768295212 · Cited by 132
Estrogen Rapidly Activates the PI3K/AKT Pathway and Hypoxia-Inducible Factor 1 and Induces Vascular Endothelial Growth Factor A Expression in Luminal Epithelial Cells of the Rat Uterus1
Kazi, A. A., Molitoris, K. H., & Koos, R. D. (2009) · Biology of Reproduction · doi:10.1095/biolreprod.109.076117 · Cited by 122
Structure of Human FIH-1 Reveals a Unique Active Site Pocket and Interaction Sites for HIF-1 and von Hippel-Lindau
Lee, C., Kim, S. J., Jeong, D. G., Lee, S. M., & Ryu, S. E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210385200 · Cited by 124
Hypoxia-Inducible Factors as Essential Regulators of Inflammation
Imtiyaz, H. Z., & Simon, M. C. (2010) · Current Topics in Microbiology and Immunology · doi:10.1007/82_2010_74 · Cited by 379
AMPK-HDAC5 pathway facilitates nuclear accumulation of HIF-1α and functional activation of HIF-1 by deacetylating Hsp70 in the cytosol
Chen, S., Yin, C., Lao, T., Liang, D., He, D., Wang, C., & Sang, N. (2015) · Cell Cycle · doi:10.1080/15384101.2015.1055426 · Cited by 127
Self-citation
Functional Analysis of Hypoxia-inducible Factor-1α-mediated Transactivation
Ruas, J. L., Poellinger, L., & Pereira, T. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205051200 · Cited by 116
The Hypoxia-Inducible Factor Pathway, Prolyl Hydroxylase Domain Protein Inhibitors, and Their Roles in Bone Repair and Regeneration
Fan, L., Li, J., Yu, Z., Dang, X., & Wang, K. (2014) · BioMed Research International · doi:10.1155/2014/239356 · Cited by 108
Histone Deacetylase Inhibitors Repress the Transactivation Potential of Hypoxia-inducible Factors Independently of Direct Acetylation of HIF-α
Fath, D. M., Kong, X., Liang, D., Lin, Z., Chou, A. D., Jiang, Y., Fang, J., Caro, J., & Sang, N. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m600456200 · Cited by 108
Self-citation
Endogenous 2-oxoacids differentially regulate expression of oxygen sensors
DALGARD, C. L., LU, H., MOHYELDIN, A., & VERMA, A. (2004) · Biochemical Journal · doi:10.1042/bj20031647 · Cited by 107
Transcriptional regulation of hypoxia inducible factors alpha (HIF-α) and their inhibiting factor (FIH-1) of channel catfish (Ictalurus punctatus) under hypoxia
Geng, X., Feng, J., Liu, S., Wang, Y., Arias, C. R., & Liu, Z. (2014) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2013.12.007 · Cited by 104
Role for casein kinase 2 in the regulation of HIF‐1 activity
Mottet, D., Ruys, S. P. D., Demazy, C., Raes, M. J., & Michiels, C. (2005) · International Journal of Cancer · doi:10.1002/ijc.21268 · Cited by 107
Two sides to every story: the HIF-dependent and HIF-independent functions of pVHL
Li, M., & Kim, W. Y. (2010) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2010.01238.x · Cited by 98
Kinetic Investigations of the Role of Factor Inhibiting Hypoxia-inducible Factor (FIH) as an Oxygen Sensor
Tarhonskaya, H., Hardy, A., Howe, E. A., Loik, N. D., Kramer, H., McCullagh, J., Schofield, C. J., & Flashman, E. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.653014 · Cited by 90
Effects of Histone Deacetylase Inhibitors on HIF-1
Liang, D., Kong, X., & Sang, N. (2006) · Cell Cycle · doi:10.4161/cc.5.21.3409 · Cited by 85
Self-citation
The role of HIF-1α in myeloid cell inflammation
Walmsley, S. R., Cadwallader, K. A., & Chilvers, E. R. (2005) · Trends in Immunology · doi:10.1016/j.it.2005.06.007 · Cited by 82
Hypoxia-inducible factor 1 mediates hypoxia-induced cardiomyocyte lipid accumulation by reducing the DNA binding activity of peroxisome proliferator-activated receptor α/retinoid X receptor
Belanger, A. J., Luo, Z., Vincent, K. A., Akita, G. Y., Cheng, S. H., Gregory, R. J., & Jiang, C. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.10.062 · Cited by 81
Erythropoietin: the story of hypoxia and a finely regulated hematopoietic hormone
Koury, M. J. (2005) · Experimental Hematology · doi:10.1016/j.exphem.2005.06.031 · Cited by 80
Transglutaminase 2 protects against ischemic insult, interacts with HIF1β, and attenuates HIF1 signaling
Filiano, A. J., Bailey, C. D. C., Tucholski, J., Gundemir, S., & Johnson, G. V. W. (2008) · The FASEB Journal · doi:10.1096/fj.07-097709 · Cited by 76
Hypoxia-inducible factor in cancer angiogenesis: Structure, regulation and clinical perspectives
Otrock, Z. K., Hatoum, H. A., Awada, A. H., Ishak, R. S., & Shamseddine, A. I. (2009) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2009.01.001 · Cited by 77
Activity of Hypoxia-inducible Factor 2α Is Regulated by Association with the NF-κB Essential Modulator
Bracken, C. P., Whitelaw, M. L., & Peet, D. J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m409987200 · Cited by 75
Histone Deacetylase Inhibitors: The Epigenetic Therapeutics That Repress Hypoxia‐Inducible Factors
Chen, S., & Sang, N. (2010) · BioMed Research International · doi:10.1155/2011/197946 · Cited by 73
Self-citation
Atorvastatin and metformin administration modulates experimental Trichinella spiralis infection
Othman, A. A., Rayia, D. M. A., Ashour, D. S., Saied, E. M., Zineldeen, D. H., & El-Ebiary, A. (2015) · Parasitology International · doi:10.1016/j.parint.2015.11.001 · Cited by 70
Hypoxia-induced Activation of the Retinoic Acid Receptor-related Orphan Receptor α4 Gene by an Interaction between Hypoxia-inducible Factor-1 and Sp1
Miki, N., 生田, 恵., & Matsui, T. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313186200 · Cited by 71
Complex Regulation of the Transactivation Function of Hypoxia-inducible Factor-1α by Direct Interaction with Two Distinct Domains of the CREB-binding Protein/p300
Ruas, J. L., Berchner‐Pfannschmidt, U., Malik, S., Gradin, K., Fandrey, J., Roeder, R. G., Pereira, T., & Poellinger, L. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.021824 · Cited by 68
Hypoxia and High Altitude
Höpfl, G., Ogunshola, O. O., & Gassmann, M. (2003) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-8997-0_7 · Cited by 67
Histone Deacetylase Inhibitors Synergize p300 Autoacetylation that Regulates Its Transactivation Activity and Complex Formation
Stiehl, D. P., Fath, D. M., Liang, D., Jiang, Y., & Sang, N. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3985 · Cited by 66
Self-citation
The hepatitis E virus ORF3 protein stabilizes HIF-1α and enhances HIF-1-mediated transcriptional activity through p300/CBP
Moin, S. M., Chandra, V. K., Arya, R. S., & Jameel, S. (2009) · Cellular Microbiology · doi:10.1111/j.1462-5822.2009.01340.x · Cited by 66
Small-Molecule Modulators of the Hypoxia-Inducible Factor Pathway: Development and Therapeutic Applications
Li, Z., You, Q., & Zhang, X. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.8b01596 · Cited by 64
Functional Integrity of Nuclear Factor κB, Phosphatidylinositol 3′-Kinase, and Mitogen-Activated Protein Kinase Signaling Allows Tumor Necrosis Factor α-Evoked Bcl-2 Expression to Provoke Internal Ribosome Entry Site-Dependent Translation of Hypoxia-Inducible Factor 1α
Zhou, J., Callapina, M., Goodall, G. J., & Brüne, B. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1437 · Cited by 62
Emerging strategies to overcome the resistance to current mTOR inhibitors in renal cell carcinoma
Santoni, M., Pantano, F., Amantini, C., Nabissi, M., Conti, A., Burattini, L., Zoccoli, A., Berardi, R., Santoni, G., Tonini, G., et al. (2014) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2014.01.007 · Cited by 60
Hypoxia-Inducible Factor 1α and Its Role in Lung Injury: Adaptive or Maladaptive
Suresh, M. V., Balijepalli, S., Solanki, S. A., Aktay, S. L., Choudhary, K., Shah, Y. M., & Raghavendran, K. (2023) · Inflammation · doi:10.1007/s10753-022-01769-z · Cited by 59
The Hypoxic Inducible Stress Response as a Target for Cancer Drug Discovery
Welsh, S. J., Koh, M. Y., & Powis, G. (2006) · Seminars in Oncology · doi:10.1053/j.seminoncol.2006.04.011 · Cited by 54
From Erythropoietin to Oxygen: Hypoxia-Inducible Factor Hydroxylases and the Hypoxia Signal Pathway
Ratcliffe, P. J. (2002) · Blood Purification · doi:10.1159/000065201 · Cited by 54
Glutamine depletion and glucose depletion trigger growth inhibition via distinctive gene expression reprogramming
Qie, S., Liang, D., Yin, C., Gu, W., Meng, M., Wang, C., & Sang, N. (2012) · Cell Cycle · doi:10.4161/cc.21944 · Cited by 52
Self-citation
The HIF/VHL Pathway
Walmsley, S. R., McGovern, N. N., Whyte, M. K. B., & Chilvers, E. R. (2007) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2007-0331tr · Cited by 52
Oxygen Levels Epigenetically Regulate Fate Switching of Neural Precursor Cells via Hypoxia‐Inducible Factor 1α‐Notch Signal Interaction in the Developing Brain
Mutoh, T., Sanosaka, T., Ito, K., & Nakashima, K. (2011) · Stem Cells · doi:10.1002/stem.1019 · Cited by 49
Synthetic transactivation screening reveals ETV4 as broad coactivator of hypoxia-inducible factor signaling
Wollenick, K., Hu, J. J., Kristiansen, G., Schraml, P., Rehrauer, H., Berchner‐Pfannschmidt, U., Fandrey, J., Wenger, R. H., & Stiehl, D. P. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr978 · Cited by 53
Considering the role of pyruvate in tumor cells during hypoxia
Roudier, E. A., & Perrin, A. (2009) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2009.02.003 · Cited by 45
Cellular mechanisms associated with intermittent hypoxia
Nanduri, J., & Nanduri, R. P. (2007) · Essays in Biochemistry · doi:10.1042/bse0430091 · Cited by 43
The Asparagine Hydroxylase FIH: A Unique Oxygen Sensor
Volkova, Y. L., Pickel, C., Jucht, A. E., Wenger, R. H., & Scholz, C. C. (2022) · Antioxidants and Redox Signaling · doi:10.1089/ars.2022.0003 · Cited by 43
DEC2 expression is positively correlated with HIF-1 activation and the invasiveness of human osteosarcomas
Hu, T., He, N., Yang, Y., Yin, C., Sang, N., & Yang, Q. (2015) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-015-0135-8 · Cited by 43
Self-citation
Asparaginyl β-Hydroxylation of Proteins Containing Ankyrin Repeat Domains Influences Their Stability and Function
Hardy, A., Prokeš, I., Kelly, L., Campbell, I. D., & Schofield, C. J. (2009) · Journal of Molecular Biology · doi:10.1016/j.jmb.2009.07.070 · Cited by 42
MicroRNAs and altered metabolism of clear cell renal cell carcinoma: Potential role as aerobic glycolysis biomarkers
Morais, M., Dias, F., Teixeira, A. L., & Medeiros, R. (2017) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2017.05.028 · Cited by 43
Molecular characterization and mRNA expression of hypoxia inducible factor-1 and cognate inhibiting factor in Macrobrachium nipponense in response to hypoxia
Sun, S., Xuan, F., Fu, H., Ge, X., Zhu, J. X., Qiao, H., Jin, S., & Zhang, W. (2016) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2016.02.002 · Cited by 41
Epigenetic regulation of hypoxia inducible factor in diseases and therapeutics
Nguyen, M. P., Lee, S., & Lee, Y. M. (2013) · Archives of Pharmacal Research · doi:10.1007/s12272-013-0058-x · Cited by 37
Resveratrol reduces oxidative damage and inflammation in mice infected withTrichinella spiralis
Elgendy, D. I., Othman, A. A., Saad, M. A. H., Soliman, N. A., & Mwafy, S. E. (2020) · Journal of Helminthology · doi:10.1017/s0022149x20000206 · Cited by 37
Modulating undruggable targets to overcome cancer therapy resistance
Passirani, C., Vessières, A., Regina, G. L., Link, W., & Silvestri, R. (2021) · Drug Resistance Updates · doi:10.1016/j.drup.2021.100788 · Cited by 37
TNFα induces expression of HIF‐1α mRNA and protein but inhibits hypoxic stimulation of HIF‐1 transcriptional activity in airway smooth muscle cells
Tsapournioti, S., Mylonis, I., Hatziefthimiou, A. A., Ιωάννου, Μ., Stamatiou, R., Koukoulis, G. K., Simos, G., Molyvdas, P., & Paraskeva, E. (2013) · Journal of Cellular Physiology · doi:10.1002/jcp.24331 · Cited by 36
Investigating hypoxia-inducible factor signaling in cancer: Mechanisms, clinical implications, targeted therapeutic strategies, and resistance
Shaikat, A. H., Azad, S. M. A. K., Tamim, M. A. R., Ullah, M. S., Amin, M. N., Sabbir, M. K., Tarun, M. T. I., Mostaq, M. S., Sabrin, S., Mahmud, M. Z., et al. (2025) · Cancer Pathogenesis and Therapy · doi:10.1016/j.cpt.2025.07.003 · Cited by 37
Expression of hypoxia inducible factor 1α and 2α and its association with vitamin C level in thyroid lesions
Jóźwiak, P., Ciesielski, P., Zaczek, A., Lipińska, A., Pomorski, L., Wieczorek, M., Bryś, M., Forma, E., & Krześlak, A. (2017) · Journal of Biomedical Science · doi:10.1186/s12929-017-0388-y · Cited by 31
Up-Regulation of ENO1 by HIF-1α in Retinal Pigment Epithelial Cells after Hypoxic Challenge Is Not Involved in the Regulation of VEGF Secretion
Zheng, F., Jang, W.-C., Fung, F. K. C., Lo, A., & Wong, I. Y. H. (2016) · PLoS ONE · doi:10.1371/journal.pone.0147961 · Cited by 31
Retinoblastoma susceptibility gene product pRB activates hypoxia-inducible factor-1 (HIF-1)
Budde, A., Schneiderhan‐Marra, N., Petersen, G., & Brüne, B. (2005) · Oncogene · doi:10.1038/sj.onc.1208369 · Cited by 31
Verifiable Hypotheses for Thymosin β4-Dependent and -Independent Angiogenic Induction of Trichinella spiralis-Triggered Nurse Cell Formation
Ock, M.-S., Cha, H., & Choi, Y. H. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms141223492 · Cited by 28
Monoclonal Antibody-Based Screening Assay for Factor Inhibiting Hypoxia-Inducible Factor Inhibitors
Lee, S.-H., Moon, J. H., Cho, E. A., Ryu, S.-E., & Lee, M. K. (2008) · SLAS DISCOVERY · doi:10.1177/1087057108318800 · Cited by 29
Hypoxia increases VEGF-A production by prostate cancer and bone marrow stromal cells and initiates paracrine activation of bone marrow endothelial cells
Muir, C., Chung, L. W. K., Carson, D. D., & Farach‐Carson, M. C. (2006) · Clinical & Experimental Metastasis · doi:10.1007/s10585-006-9021-2 · Cited by 32

Authors: Sang, N., Fang, J., Srinivas, V., Leshchinsky, I., & Caro, J.
Affiliations: Thomas Jefferson University (US)
Corresponding author: Caro, Jaime
ORCID: Sang, Nianli
Venue: Molecular and Cellular Biology
Publisher: Informa UK Limited
Published: 2002-05-01
Volume: 22
Issue: 9
Pages: 2984-2992
ISSN: 0270-7306 (ISSN-L)
1098-5549
DOI: 10.1128/mcb.22.9.2984-2992.2002
PMC: PMC133771
OpenAlex: W2121895466
Cited by: 143
References: 55
Citations by year: 2025: 2 · 2024: 2 · 2023: 6 · 2022: 3 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 3 · 2016: 5 · 2015: 8 · 2014: 3 · 2013: 5 · 2012: 4
FWCI: 6.64
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Molecular and Cellular Biology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: American Heart Association
Fudan University
Huashan Hospital
National Institutes of Health
National Heart, Lung, and Blood Institute (T32HL007821)
National Cancer Institute (R01CA089212, R01CA89212-02)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Kruppel-like factors research
Keywords: hypoxia-inducible factor-1α, prolyl hydroxylase, von Hippel-Lindau protein, CBP/p300, deferoxamine, hypoxia, oxygen homeostasis, transcriptional regulation, protein stability
MeSH terms: Hypoxia, Aspartate Carbamoyltransferase, Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing), Cell Line, Deferoxamine, Dihydroorotase, DNA-Binding Proteins, HeLa Cells, Humans, Mixed Function Oxygenases, Hydroxylation, Ligases, Multienzyme Complexes, Nuclear Proteins, Protein Binding, Transcription Factors, Blotting, Western, Transcriptional Activation, Trans-Activators, Adenovirus E1A Proteins, Protein Isoforms, Tumor Suppressor Proteins, Ubiquitin-Protein Ligases, Hypoxia-Inducible Factor 1, Von Hippel-Lindau Tumor Suppressor Protein, Hypoxia-Inducible Factor 1, alpha Subunit

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Carboxyl-Terminal Transactivation Activity of Hypoxia-Inducible Factor 1α Is Governed by a von Hippel-Lindau Protein-Independent, Hydroxylation-Regulated Association with p300/CBP

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks