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PPARγ Is Required for the Differentiation of Adipose Tissue In Vivo and In Vitro

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Cholesterol and Bile Acid Metabolism Are Impaired in Mice Lacking the Nuclear Oxysterol Receptor LXRα

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The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

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SXR, a novel steroid and xenobioticsensing nuclear receptorPreprint

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Environmental enrichment alters protein expression as well as the proteomic response to cocaine in rat nucleus accumbens

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Identification of Estrogen-Related Receptor α Agonists in the Tox21 Compound Library

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Curcumin Relieves Chronic Unpredictable Mild Stress-Induced Depression-Like Behavior through the PGC-1α/FNDC5/BDNF Pathway

Wu, Y., Sun, F., Guo, Y., Zhang, Y., Li, L., Dang, R., & Jiang, P. (2021) · Behavioural Neurology · doi:10.1155/2021/2630445 · Cited by 37

Insulin action and resistance are dependent on a GSK3β-FBXW7-ERRα transcriptional axis

Xia, H., Scholtes, C., Dufour, C. R., Ouellet, C., Ghahremani, M., & Giguère, V. (2022) · Nature Communications · doi:10.1038/s41467-022-29722-6 · Cited by 33

GNL3L inhibits activity of estrogen-related receptor γ by competing for coactivator binding

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ERRα regulates osteoblastic and adipogenic differentiation of mouse bone marrow mesenchymal stem cells

Rajalin, A.-M., Pollock, H., & Aarnisalo, P. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.04.120 · Cited by 31

Involvement of the orphan nuclear estrogen receptor-related receptor α in osteoclast adhesion and transmigration

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Cloning and developmental expression of five estrogen-receptor related genes in the zebrafish

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Involvement of Estrogen Receptor β in the Induction of Polyovular Follicles in Mouse Ovaries Exposed Neonatally to Diethylstilbestrol

Kirigaya, A., Kim, H., Hayashi, S., Chambon, P., Watanabe, H., lguchi, T., & Sato, T. (2009) · ZOOLOGICAL SCIENCE · doi:10.2108/zsj.26.704 · Cited by 31

Nuclear receptor ERRα and coactivator PGC-1β are effectors of IFN-γ-induced host defensePreprint

Sonoda, J., Laganière, J., Mehl, I. R., Barish, G. D., Chong, L.-W., Li, X., Scheffler, I. E., Mock, D. C., Bataille, A. R., Robert, F., et al. (2007) · Genes & Development · doi:10.1101/gad.1553007 · Cited by 218

Estrogen receptor-related receptors in the killifish Fundulus heteroclitus : diversity, expression, and estrogen responsiveness

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A novel steroidal inhibitor of estrogen-related receptor α (ERRα)

Duellman, S. J., Calaoagan, J. M., Sato, B., Fine, R., Klebansky, B., Chao, W., Hobbs, P. D., Collins, N., Sambucetti, L. C., & Laderoute, K. R. (2010) · Biochemical Pharmacology · doi:10.1016/j.bcp.2010.05.024 · Cited by 30

Estrogen receptor–related receptor α regulation by interleukin‐1β in prostaglandin E2– and cAMP‐dependent pathways in osteoarthritic chondrocytes

Bonnelye, E., Reboul, P., Duval, N., Cardelli, M., & Aubin, J. E. (2011) · Arthritis & Rheumatism · doi:10.1002/art.30398 · Cited by 30

Transcriptional Regulation of ROS Homeostasis by the ERR Subfamily of Nuclear Receptors

Scholtes, C., & Giguère, V. (2021) · Antioxidants · doi:10.3390/antiox10030437 · Cited by 33

A Synthetic ERR Agonist Alleviates Metabolic Syndrome

Billon, C., Schoepke, E., Avdagic, A., Chatterjee, A., Butler, A. A., Elgendy, B., Walker, J. K., & Burris, T. P. (2023) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.123.001733 · Cited by 33

Up-regulation of orphan nuclear estrogen-related receptor alpha expression during long-term caloric restriction in mice

Ranhotra, H. S. (2009) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-009-0174-6 · Cited by 29

Recent Advance in the Design of Small Molecular Modulators of Estrogen-Related Receptors

Lu, X., Peng, L., Lv, M., & ding, K. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212801227113 · Cited by 28

Inhibition of Estrogen-Related Receptor α Blocks Liver Steatosis and Steatohepatitis and Attenuates Triglyceride Biosynthesis

Chen, C.-Y., Li, Y., Zeng, N., He, L., Zhang, X., Tu, T., Tang, Q., Alba, M. M., Mir, S., Stiles, E. X., et al. (2021) · American Journal Of Pathology · doi:10.1016/j.ajpath.2021.04.007 · Cited by 31

Emerging Role of Nuclear Receptors for the Treatment of NAFLD and NASH

Welch, R. D., Billon, C., Losby, M., Bedia‐Diaz, G., Fang, Y., Avdagic, A., Elgendy, B., Burris, T. P., & Griffett, K. (2022) · Metabolites · doi:10.3390/metabo12030238 · Cited by 28

Effects of estrogen-related receptor alpha (ERRα) on proliferation and metastasis of human lung cancer A549 cells

Huang, J., Guan, B., Yin, L., Liu, F., Hu, B., Zheng, Q.-Y., Li, F.-L., Zhong, Y.-X., & Chen, Y. (2014) · Journal of Huazhong University of Science and Technology [Medical Sciences] · doi:10.1007/s11596-014-1367-0 · Cited by 28

Estradiol mediates vasculoprotection via ERRα-dependent regulation of lipid and ROS metabolism in the endothelium

Li, H., Liu, Z., Gou, Y., Yu, H., Siminelakis, S. N., Wang, S., Kong, D., Zhou, Y., Liu, Z., Ding, Y., et al. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.08.008 · Cited by 28

Suppressing the activity of ERRα in 3T3‐L1 adipocytes reduces mitochondrial biogenesis but enhances glycolysis and basal glucose uptake

Nie, Y., & Wong, C. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00382.x · Cited by 28

ERRα negatively regulates type I interferon induction by inhibiting TBK1-IRF3 interaction

He, X., Ma, S., Tian, Y., Wei, C., Zhu, Y., Li, F., Zhang, P., Wang, P., Zhang, Y., & Zhong, H. (2017) · PLoS Pathogens · doi:10.1371/journal.ppat.1006347 · Cited by 29

ERRα suppression enhances the cytotoxicity of the MEK inhibitor trametinib against colon cancer cells

Zhou, S., Xia, H., Xu, H., Tang, Q., Nie, Y., Gong, Q., & Bi, F. (2018) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-018-0862-8 · Cited by 28

Electron Transport Disturbances and Neurodegeneration: From Albert Szent-Györgyi’s Concept (Szeged) till Novel Approaches to Boost Mitochondrial Bioenergetics

Szalárdy, L., Zádori, D., Klivènyi, P., Toldi, J., & Vécsei, L. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/498401 · Cited by 30

Conserved and Exapted Functions of Nuclear Receptors in Animal Development

Bodofsky, S., Koitz, F., & Wightman, B. (2017) · Nuclear Receptor Research · doi:10.11131/2017/101305 · Cited by 28

Estrogen-related receptor alpha (ERRα) is a key regulator of intestinal homeostasis and protects against colitis

Tran, A., Scholtes, C., Songane, M., Champagne, C., Galarneau, L., Levasseur, M.-P., Fodil, N., Dufour, C. R., Giguère, V., & Saleh, M. (2021) · Scientific Reports · doi:10.1038/s41598-021-94499-5 · Cited by 27

Research Resource: Rapid Recruitment of Temporally Distinct Vascular Gene Sets by Estrogen

Schnoes, K. K., Jaffe, I. Z., Iyer, L. K., Dabreo, A., Aronovitz, M. J., Newfell, B. G., Hansen, U. M., Rosano, G. M. C., & Mendelsohn, M. E. (2008) · Molecular Endocrinology · doi:10.1210/me.2008-0044 · Cited by 26

Estrogen related receptor α-induced adipogenesis is PGC-1β-dependent

Ju, D., He, J., Zhao, L., Zheng, X., & Yang, G. (2011) · Molecular Biology Reports · doi:10.1007/s11033-011-1104-8 · Cited by 26

Orphan nuclear receptor oestrogen-related receptor γ (ERRγ) plays a key role in hepatic cannabinoid receptor type 1-mediated induction of CYP7A1 gene expression

Zhang, Y., Kim, D., Lee, J.-M., Park, S. B., Jeong, W., Kim, S. H., Lee, I., Lee, C., Chiang, J. Y. L., & Choi, H.-S. (2015) · Biochemical Journal · doi:10.1042/bj20141494 · Cited by 25

Estrogen-Related Receptors and the control of bone cell fate

Carnesecchi, J., & Vanacker, J.-M. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.07.019 · Cited by 26

The cannabinoid receptor inverse agonist AM251 regulates the expression of the EGF receptor and its ligands via destabilization of oestrogen‐related receptor α protein

Fiori, J. L., Sanghvi, M., O'Connell, M., Krzysik-Walker, S. M., Moaddel, R., & Bernier, M. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01384.x · Cited by 24

Estrogen receptor-related receptor- (ERR- ) is dysregulated in inflammatory arthritis

Bonnelye, E., Laurin, N., Jurdic, P., Hart, D. A., & Aubin, J. E. (2008) · Lara D. Veeken · doi:10.1093/rheumatology/ken368 · Cited by 24

Insights into the role of estrogen-related receptors α, β and γ in tumor Leydig cells

Kotula‐Balak, M., Milon, A., Pawlicki, P., Opydo‐Chanek, M., Pacwa, A., Lesniak, K., Sekuła, M., Zarzycka, M., Bubka, M., Tworzydlo, W., et al. (2018) · Tissue and Cell · doi:10.1016/j.tice.2018.04.003 · Cited by 24

Loss of Estrogen-Related Receptor Alpha Facilitates Angiogenesis in Endothelial Cells

Likhite, N., Yadav, V., Milliman, E. J., Sopariwala, D. H., Lorca, S., Narayana, N. P., Sheth, M., Reineke, E. L., Giguère, V., & Narkar, V. A. (2019) · Molecular and Cellular Biology · doi:10.1128/mcb.00411-18 · Cited by 24

Estrogen‐related receptor participates in regulating glycolysis and influences embryonic development in silkworm Bombyx mori

Long, W., Wu, J., Shen, G., Zhang, H., Liu, H., Xu, Y., Gu, J., Jia, L., Lin, Y., & Xia, Q. (2019) · Insect Molecular Biology · doi:10.1111/imb.12619 · Cited by 23

Cloning and molecular characterization of estrogen-related receptor (ERR) and vitellogenin genes in the brackish water flea Diaphanosoma celebensis exposed to bisphenol A and its structural analogues

In, S., Cho, H., Lee, K., Won, E., & Lee, Y. (2020) · Marine Pollution Bulletin · doi:10.1016/j.marpolbul.2020.111063 · Cited by 23

The ERRα orphan nuclear receptor controls morphogenetic movements during zebrafish gastrulation

Bardet, P., Horard, B., Laudet, V., & Vanacker, J.-M. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.02.018 · Cited by 23

Genetic analysis of the estrogen-related receptor α and studies of association with obesity and type 2 diabetes

Larsen, L. H., Rose, C. S., Sparsø, T., Overgaard, A. J., Torekov, S. S., Grarup, N., Jensen, D. P., Albrechtsen, A., Andersen, G., Ek, J., et al. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803408 · Cited by 23

ERRα Regulates OTUB1 Expression to Promote Colorectal Cancer Cell Migration

Zhou, Y., Jia, Q., Meng, X., Chen, D., & Zhu, B. (2019) · Journal of Cancer · doi:10.7150/jca.30720 · Cited by 22

Estrogen Related Receptor-α EnhancesSurfactant Protein-AGene Expression in Fetal Lung Type II Cells

Liu, D., Hinshelwood, M. M., Giguère, V., & Mendelson, C. R. (2006) · Endocrinology · doi:10.1210/en.2006-0664 · Cited by 22

Identification of Compounds That Inhibit Estrogen-Related Receptor Alpha Signaling Using High-Throughput Screening Assays

Lynch, C., Zhao, J., Sakamuru, S., Zhang, L., Huang, R., Witt, K. L., Merrick, B. A., Teng, C. T., & Xia, M. (2019) · Molecules · doi:10.3390/molecules24050841 · Cited by 21

Evaluation of the porcine ACSL4 gene as a candidate gene for meat quality traits in pigs

Corominas, J., Ramayo‐Caldas, Y., Castelló, A., Muñoz, M., Ibáñez‐Escriche, N., Folch, J. M., & Ballester, M. (2012) · Animal Genetics · doi:10.1111/j.1365-2052.2012.02335.x · Cited by 21

Targeting nuclear receptors for NASH/MASH: From bench to bedside

Sinha, R. A. (2024) · Liver Research · doi:10.1016/j.livres.2024.03.002 · Cited by 20

ERRγ Is Not Required for Skeletal Development but Is a RUNX2-Dependent Negative Regulator of Postnatal Bone Formation in Male Mice

Cardelli, M., & Aubin, J. E. (2014) · PLoS ONE · doi:10.1371/journal.pone.0109592 · Cited by 20

Oestrogen‐related receptor reduces vitellogenin expression by crosstalk with the ecdysone receptor pathway in female silkworm, Bombyx mori

Shen, G., Wu, J., Han, C., Liu, H., Xu, Y., Zhang, H., Lin, Y., & Xia, Q. (2018) · Insect Molecular Biology · doi:10.1111/imb.12385 · Cited by 20

Estrogen-related receptor α is involved in the osteogenic differentiation of mesenchymal stem cells isolated from human periodontal ligaments

Cai, C., YUAN, G.-J., Huang, Y., Yang, N., Chen, X., WEN, L., Wang, X., ZHANG, L., & Ding, Y. (2013) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2013.1305 · Cited by 20

Discovery of a Novel Class of ERRα Agonists

Shinozuka, T., Ito, S., Kimura, T., Izumi, M., & Wakabayashi, K. (2021) · ACS Medicinal Chemistry Letters · doi:10.1021/acsmedchemlett.1c00100 · Cited by 22

PGC-1α coactivates estrogen-related receptor-α to induce the expression of glucokinase

Zhu, L., Liu, Y., Cui, A., Шао, Д., Liang, J., Liu, X., Chen, Y., Gupta, N., Fang, F., & Chang, Y. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00633.2009 · Cited by 20

Cardiac-Specific Overexpression of ERRγ in Mice Induces Severe Heart Dysfunction and Early Lethality

Lasheras, J., Pardo, R., Velilla, M., Poncelas, M., Salvatella, N., Simó, R., Ruiz‐Meana, M., Zamora, M., & Villena, J. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158047 · Cited by 17

Histone Deacetylase 3 Governs β-Estradiol-ERα-Involved Endometrial Tumorigenesis via Inhibition of STING Transcription

Chen, G., Yan, Q., Liu, L., Wen, X., Zeng, H., & Yin, S. (2022) · Cancers · doi:10.3390/cancers14194718 · Cited by 19

High Salt Diet Affects Renal Sodium Excretion and ERRα Expression

Wang, D., Wang, Y., Liu, F., Yuan, Z., & Mu, J. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17040480 · Cited by 19

Metabolism rather than obesity is associated with ischemic stroke: a cross-sectional study in rural Northeastern China

Li, Z., Guo, X., Liu, Y., Zhang, N., Chang, Y., Chen, Y., Sun, Y., & Abraham, M. R. (2016) · SpringerPlus · doi:10.1186/s40064-016-3088-2 · Cited by 17

Evidence for a role of oestrogen receptor‐related receptor in the regulation of male sexual behaviour in the moth Agrotis ipsilon

Bozzolan, F., Durand, N., Demondion, E., Bourgeois, T. P., Gassias, E., & Debernard, S. (2017) · Insect Molecular Biology · doi:10.1111/imb.12303 · Cited by 18

The capacity for oestrogen to influence obesity through brown adipose tissue thermogenesis in animal models: A systematic review and meta‐analysis

Sievers, W., Rathner, J. A., Kettle, C., Zacharias, A., Irving, H. R., & Green, R. A. (2019) · Obesity Science & Practice · doi:10.1002/osp4.368 · Cited by 17

The Orphan Nuclear Receptor ERRγ Regulates Hepatic CB1 Receptor-Mediated Fibroblast Growth Factor 21 Gene Expression

Jung, Y. S., Lee, J.-M., Kim, D., Lee, Y. S., Kim, K.-S., Kim, Y., Kim, J., Lee, M., Lee, I., Kim, S. H., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0159425 · Cited by 18

Molecular dynamics of estrogen-related receptors and their regulatory proteins: roles in transcriptional control for endocrine and metabolic signaling

Tanida, T. (2021) · Anatomical Science International · doi:10.1007/s12565-021-00634-7 · Cited by 19

Estrogen-related receptor α (ERRα): A novel target in type 2 diabetes

Handschin, C., & Mootha, V. K. (2005) · Drug Discovery Today Therapeutic Strategies · doi:10.1016/j.ddstr.2005.05.001 · Cited by 17

Estrogen-Related Receptor , the Molecular Clock, and Transcriptional Control of Metabolic OutputsPreprint

Giguère, V., Dufour, C. R., Eichner, L. J., Deblois, G., & Cermakian, N. (2011) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2011.76.011031 · Cited by 17

Hepatocyte FBXW7-dependent activity of nutrient-sensing nuclear receptors controls systemic energy homeostasis and NASH progression in male mice

Xia, H., Dufour, C. R., Medkour, Y., Scholtes, C., Chen, Y., Guluzian, C., B'Chir, W., & Giguère, V. (2023) · Nature Communications · doi:10.1038/s41467-023-42785-3 · Cited by 17

Neuropathology of Partial PGC-1α Deficiency Recapitulates Features of Mitochondrial Encephalopathies but Not of Neurodegenerative Diseases

Szalárdy, L., Zádori, D., Plangár, I., Vécsei, L., Weydt, P., Ludolph, A. C., Klivènyi, P., & Kovács, G. G. (2013) · Neurodegenerative Diseases · doi:10.1159/000346267 · Cited by 16

Peroxisome Proliferator-Activated Receptor γ Coactivator-1α Enhances Antiproliferative Activity of 5′-Deoxy-5-Fluorouridine in Cancer Cells through Induction of Uridine Phosphorylase

Kong, X., Fan, H., Liu, X., Wang, R., Liang, J., Gupta, N., Chen, Y., Fang, F., & Chang, Y. (2009) · Molecular Pharmacology · doi:10.1124/mol.109.056424 · Cited by 16

Molecular Mechanisms for Age-Associated Mitochondrial Deficiency in Skeletal Muscle

Wagatsuma, A., & Sakuma, K. (2012) · Journal of Aging Research · doi:10.1155/2012/768304 · Cited by 15

Cartilage-Specific Overexpression of ERRγ Results in Chondrodysplasia and Reduced Chondrocyte Proliferation

Cardelli, M., Zirngibl, R. A., Boetto, J. F., McKenzie, K. P., Troy, T., Turksen, K., & Aubin, J. E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0081511 · Cited by 15

The emerging role of estrogen related receptorα in complications of non‑small cell lung cancers (Review)

Mukherjee, T. K., Malik, P., & Hoidal, J. R. (2021) · Oncology Letters · doi:10.3892/ol.2021.12519 · Cited by 14

Orphan nuclear receptor ERRγ regulates hepatic TGF-β2 expression and fibrogenic response in CCl4-induced acute liver injury

Jung, Y. S., Kim, Y., Radhakrishnan, K., Kim, J., Lee, I., Cho, S. J., Kim, D., Dooley, S., Lee, C., & Choi, H. (2021) · Archives of Toxicology · doi:10.1007/s00204-021-03112-1 · Cited by 14

Regulation of germ layer formation by pluripotency factors during embryogenesis

Cao, Y. (2013) · Cell & Bioscience · doi:10.1186/2045-3701-3-15 · Cited by 14

Loss of estrogen-related receptor alpha disrupts ventral-striatal synaptic function in female mice

Jesús‐Cortés, H. D., Lü, Y., Anderson, R. M., Khan, M. Z., Nath, V., McDaniel, L., Lutter, M. L., Radley, J. J., Pieper, A. A., & Cui, H. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.04.054 · Cited by 13

The mitochondrial calcium homeostasis orchestra plays its symphony: Skeletal muscle is the guest of honor

Gherardi, G., Mario, A. D., & Mammucari, C. (2021) · International review of cytology · doi:10.1016/bs.ircmb.2021.03.005 · Cited by 13

The 2.3 Genotype of ESRRA23 of the ERRα Gene Is Associated with a Higher BMI Than the 2.2 Genotype

Kamei, Y., Lwin, H., Saito, K., Yokoyama, T., Yoshiike, N., Ezaki, O., & Tanaka, H. (2005) · Obesity Research · doi:10.1038/oby.2005.225 · Cited by 13

Estrogen-related receptor alpha in select host functions and cancer: new frontiers

Ranhotra, H. S. (2022) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-022-04380-w · Cited by 12

Transcriptional control of cardiac energy metabolism in health and disease: Lessons from animal models

Rubio‐Tomás, T., Soler‐Botija, C., Martínez-Estrada, O. M., & Villena, J. A. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116185 · Cited by 13

Evaluation of Allium Vegetables for Anti-Adipogenic, Anti-Cancer, and Anti-Inflammatory Activities InVitro

Park, H. S., Choi, E. J., Lee, J., & Kim, G. (2013) · Journal of Life Sciences · doi:10.1080/09751270.2013.11885219 · Cited by 12

Discovery of JND003 as a New Selective Estrogen-Related Receptor α Agonist Alleviating Nonalcoholic Fatty Liver Disease and Insulin Resistance

Mao, L., Peng, L., Ren, X., Chu, Y., Nie, T., Lin, W., Libby, A. E., Xu, Y., Chang, Y., Lei, C., et al. (2022) · ACS Bio & Med Chem Au · doi:10.1021/acsbiomedchemau.1c00050 · Cited by 14

Molecular Cloning, Characterization, and Expression Analysis of an Estrogen Receptor-Related Receptor Homologue in the Cricket,Teleogryllus emma

He, H., Geng-si, X., & Lu, X. (2010) · Journal of Insect Science · doi:10.1673/031.010.18801 · Cited by 11

The Biarylpyrazole Compound AM251 Alters Mitochondrial Physiology via Proteolytic Degradation of ERRα

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Association of Polymorphisms in Mitofusin-2 Gene with Type 2 Diabetes in Han Chinese

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