Reduced fat mass in mice lacking orphan nuclear receptor estrogen-related receptor α.

The Steroid and Thyroid Hormone Receptor Superfamily

Evans, R. M. (1988) · Science · doi:10.1126/science.3283939 · Cited by 7,394

The nuclear receptor superfamily: the second decade

Mangelsdorf, D. J., Thummel, C., Beato, M., Herrlich, P., Schütz, G., Umesono, K., Blumberg, B., Kastner, P., Mark, M., Chambon, P., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90199-x · Cited by 6,964

Nuclear Receptors and Lipid Physiology: Opening the X-Files

Chawla, A., Repa, J. J., Evans, R. M., & Mangelsdorf, D. J. (2001) · Science · doi:10.1126/science.294.5548.1866 · Cited by 2,085

PPARγ Is Required for the Differentiation of Adipose Tissue In Vivo and In Vitro

Rosen, E. D., Sarraf, P., Troy, A. E., Bradwin, G., Moore, K. J., Milstone, D. S., Spiegelman, B. M., & Mortensen, R. M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80211-7 · Cited by 2,081

PPARγ Is Required for Placental, Cardiac, and Adipose Tissue Development

Barak, Y., Nelson, M. C., Ong, E. S., Jones, Y., Ruiz‐Lozano, P., Chien, K. R., Koder, A., & Evans, R. M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80209-9 · Cited by 1,983

Cholesterol and Bile Acid Metabolism Are Impaired in Mice Lacking the Nuclear Oxysterol Receptor LXRα

Peet, D. J., Turley, S. D., Ma, W., Janowski, B. A., Lobaccaro, J. A., Hammer, R. E., & Mangelsdorf, D. J. (1998) · Cell · doi:10.1016/s0092-8674(00)81432-4 · Cited by 1,466

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

Staudinger, J. L., Goodwin, B. J., Jones, S. A., Hawkins‐Brown, D., MacKenzie, K. I., Latour, A. M., Liu, Y., Klaassen, C. D., Brown, K. K., Reinhard, J. F., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051551698 · Cited by 1,378

Increased adipose tissue in male and female estrogen receptor-α knockout mice

Heine, P. A., Taylor, J. A., Iwamoto, G. A., Lubahn, D. B., & Cooke, P. S. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.23.12729 · Cited by 1,282

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

Tybulewicz, V. L. J., Crawford, C. E., Jackson, P. K., Bronson, R. T., & Mulligan, R. C. (1991) · Cell · doi:10.1016/0092-8674(91)90011-m · Cited by 1,281

SXR, a novel steroid and xenobioticsensing nuclear receptorPreprint

Blumberg, B., Sabbagh, W., Juguilon, H., Bolado, J., van Meter, C. M., Ong, E. S., & Evans, R. M. (1998) · Genes & Development · doi:10.1101/gad.12.20.3195 · Cited by 912

Transcriptional paradigms in mammalian mitochondrial biogenesis and function

Scarpulla, R. C. (2008) · Physiological Reviews · doi:10.1152/physrev.00025.2007 · Cited by 1,666

Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway

Wrann, C. D., White, J. P., Salogiannnis, J., Laznik-Bogoslavski, D., Wu, J., Ma, D., Lin, J. D., Greenberg, M. E., & Spiegelman, B. M. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.09.008 · Cited by 1,440

Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network

Scarpulla, R. C. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2010.09.019 · Cited by 1,281

Metabolic Regulation of T Lymphocytes

MacIver, N. J., Michalek, R. D., & Rathmell, J. C. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-095956 · Cited by 1,244

The Human Obesity Gene Map: The 2005 Update

Rankinen, T., Zuberi, A., Chagnon, Y. C., Weisnagel, S. J., Argyropoulos, G., Walts, B., Pérusse, L., & Bouchard, C. (2006) · Obesity · doi:10.1038/oby.2006.71 · Cited by 1,119

Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network

Bookout, A. L., Jeong, Y., Downes, M., Yu, R. T., Evans, R. M., & Mangelsdorf, D. J. (2006) · Cell · doi:10.1016/j.cell.2006.06.049 · Cited by 1,015

PGC-1α Deficiency Causes Multi-System Energy Metabolic Derangements: Muscle Dysfunction, Abnormal Weight Control and Hepatic Steatosis

Leone, T. C., Lehman, J. J., Finck, B. N., Schaeffer, P. J., Wende, A. R., Boudina, S., Courtois, M., Wozniak, D. F., Sambandam, N., Bernal-Mizrachi, C., et al. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030101 · Cited by 951

Nuclear Receptor Expression Links the Circadian Clock to Metabolism

Yang, X., Downes, M., Yu, R. T., Bookout, A. L., He, W., Straume, M., Mangelsdorf, D. J., & Evans, R. M. (2006) · Cell · doi:10.1016/j.cell.2006.06.050 · Cited by 946

Transcriptional integration of mitochondrial biogenesis

Scarpulla, R. C., Vega, R. B., & Kelly, D. P. (2012) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2012.06.006 · Cited by 798

Sirtuin 3, a New Target of PGC-1α, Plays an Important Role in the Suppression of ROS and Mitochondrial Biogenesis

Kong, X., Wang, R., Xue, Y., Liu, X., Zhang, H., Chen, Y., Fang, F., & Chang, Y. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011707 · Cited by 718

ERRα and Gabpa/b specify PGC-1α-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle.

Mootha, V. K., Handschin, C., Arlow, D., Xie, X., St. Pierre, J., Sihag, S., Yang, W., Altshuler, D., Puigserver, P., Patterson, N., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401401101 · Cited by 688

The estrogen-related receptor α (ERRα) functions in PPARγ coactivator 1α (PGC-1α)-induced mitochondrial biogenesis

Schreiber, S., Emter, R., Hock, M. B., Knutti, D., Cardenas, J., Podvinec, M., Oakeley, E. J., & Kralli, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308686101 · Cited by 678

Transcriptional Control of Mitochondrial Biogenesis and Function

Hock, M. B., & Kralli, A. (2009) · Annual Review of Physiology · doi:10.1146/annurev.physiol.010908.163119 · Cited by 626

Transcriptional Control of Energy Homeostasis by the Estrogen-Related Receptors

Giguère, V. (2008) · Endocrine Reviews · doi:10.1210/er.2008-0017 · Cited by 604

The role of mitochondria in the pathogenesis of type 2 diabetes

Patti, M.-E., & Corvera, S. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0027 · Cited by 551

Nuclear control of respiratory gene expression in mammalian cells

Scarpulla, R. C. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20743 · Cited by 489

Estrogen-Related Receptor α Directs Peroxisome Proliferator-Activated Receptor α Signaling in the Transcriptional Control of Energy Metabolism in Cardiac and Skeletal Muscle

Huss, J. M., Pineda‐Torra, I., Staels, B., Giguère, V., & Kelly, D. P. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.20.9079-9091.2004 · Cited by 498

Nuclear Receptor Signaling and Cardiac Energetics

Huss, J. M., & Kelly, D. P. (2004) · Circulation Research · doi:10.1161/01.res.0000141774.29937.e3 · Cited by 474

Genome-wide Orchestration of Cardiac Functions by the Orphan Nuclear Receptors ERRα and γ

Dufour, C. R., Wilson, B. J., Huss, J. M., Kelly, D. P., Alaynick, W. A., Downes, M., Evans, R. M., Blanchette, M., & Giguère, V. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.03.007 · Cited by 431

Nuclear receptor corepressor RIP140 regulates fat accumulation

Leonardsson, G., Steel, J. H., Christian, M., Pocock, V., Milligan, S., Bell, J., So, P.-W., Medina-Gomez, G., Vidal-Puig, A., White, R., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401013101 · Cited by 366

PGC-1α Coactivates PDK4 Gene Expression via the Orphan Nuclear Receptor ERRα: a Mechanism for Transcriptional Control of Muscle Glucose Metabolism

Wende, A. R., Huss, J. M., Schaeffer, P. J., Giguère, V., & Kelly, D. P. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.24.10684-10694.2005 · Cited by 354

The Human Obesity Gene Map: The 2004 Update

Përusse, L., Rankinen, T., Zuberi, A. R., Chagnon, Y. C., Weisnagel, S. J., Argyropoulos, G. A., Walts, B., Snyder, E. E., & Bouchard, C. (2005) · Obesity Research · doi:10.1038/oby.2005.50 · Cited by 328

ERRγ Directs and Maintains the Transition to Oxidative Metabolism in the Postnatal Heart

Alaynick, W. A., Kondo, R. P., Xie, W., He, W., Dufour, C. R., Downes, M., Jonker, J. W., Giles, W. R., Naviaux, R. K., Giguère, V., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.06.007 · Cited by 311

The Drosophila Estrogen-Related Receptor Directs a Metabolic Switch that Supports Developmental Growth

Tennessen, J. M., Baker, K. D., Lam, G., Evans, J. M., & Thummel, C. S. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.01.005 · Cited by 290

The Nuclear Receptor ERRα Is Required for the Bioenergetic and Functional Adaptation to Cardiac Pressure Overload

Huss, J. M., Imahashi, K., Dufour, C. R., Weinheimer, C. J., COURTOIS, M. R., Kovács, A., Giguère, V., Murphy, E., & Kelly, D. P. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.06.005 · Cited by 270

ERRα: a metabolic function for the oldest orphan

Villena, J. A., & Kralli, A. (2008) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2008.07.005 · Cited by 252

PPARs and ERRs: molecular mediators of mitochondrial metabolism

Fan, W., & Evans, R. M. (2014) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2014.11.002 · Cited by 266

PGC1β Mediates PPARγ Activation of Osteoclastogenesis and Rosiglitazone-Induced Bone Loss

Wei, W., Wang, X., Yang, M., Smith, L. C., Dechow, P. C., & Wan, Y. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.04.015 · Cited by 247

International Union of Pharmacology. LXVI. Orphan Nuclear Receptors

Benoit, G., Cooney, A. J., Giguère, V., Ingraham, H. A., Lazar, M., Muscat, G. E. O., Perlmann, T., Renaud, J., Schwabe, J. W. R., Sladek, F. M., et al. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.4.10 · Cited by 247

Suppression of oxidative metabolism and mitochondrial biogenesis by the transcriptional corepressor RIP140 in mouse adipocytes

Powelka, A. M. (2005) · Journal of Clinical Investigation · doi:10.1172/jci26040 · Cited by 236

A Nuclear Receptor Atlas: 3T3-L1 Adipogenesis

Fu, M., Sun, T., Bookout, A. L., Downes, M., Yu, R. T., Evans, R. M., & Mangelsdorf, D. J. (2005) · Molecular Endocrinology · doi:10.1210/me.2004-0539 · Cited by 233

β-adrenoceptor signaling networks in adipocytes for recruiting stored fat and energy expenditure

Collins, S. (2011) · Frontiers in Endocrinology · doi:10.3389/fendo.2011.00102 · Cited by 241

Oestrogen-related receptors in breast cancer: control of cellular metabolism and beyond

Deblois, G., & Giguère, V. (2012) · Nature reviews. Cancer · doi:10.1038/nrc3396 · Cited by 230

Constitutive activities of estrogen-related receptors: Transcriptional regulation of metabolism by the ERR pathways in health and disease

Huss, J. M., Garbacz, W. G., & Xie, W. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.06.016 · Cited by 222

Evidence for Ligand-independent Transcriptional Activation of the Human Estrogen-related Receptor α (ERRα)

Kallen, J. A., Schlaeppi, J.-M., Bitsch, F., Filipuzzi, I., Schilb, A., Riou, V., Graham, A., Strauss, A., Geiser, M., & Fournier, B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407999200 · Cited by 226

Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiation

Michalek, R. D., Gerriets, V. A., Nichols, A. G., Inoue, M., Kazmin, D., Chang, C.-Y., Dwyer, M. A., Nelson, E. R., Pollizzi, K. N., Ilkayeva, O., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1108856108 · Cited by 216

Orphan nuclear receptor estrogen-related receptor α is essential for adaptive thermogenesis

Villena, J. A., Hock, M. B., Chang, W. Y., Barcas, J. E., Giguère, V., & Kralli, A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607696104 · Cited by 215

Integrative regulation of physiology by histone deacetylase 3

Emmett, M. J., & Lazar, M. A. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0076-0 · Cited by 202

Mitochondrial Etiology of Neuropsychiatric Disorders

Pei, L., & Wallace, D. C. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.11.018 · Cited by 203

Estrogen related receptors (ERRs): A new dawn in transcriptional control of mitochondrial gene networks

Eichner, L. J., & Giguère, V. (2011) · Mitochondrion · doi:10.1016/j.mito.2011.03.121 · Cited by 208

Placental mitochondrial content and function in intrauterine growth restriction and preeclampsia

Mandò, C., De Palma, C., Stampalija, T., Anelli, G. M., Figus, M., Novielli, C., Parisi, F., Clementi, E., Ferrazzi, E., & Cetin, I. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00426.2013 · Cited by 196

Histone deacetylase 3 prepares brown adipose tissue for acute thermogenic challenge

Emmett, M. J., Lim, H., Jager, J., Richter, H. J., Adlanmérini, M., Peed, L. C., Briggs, E. R., Steger, D. J., Ma, T., Sims, C. A., et al. (2017) · Nature · doi:10.1038/nature22819 · Cited by 200

Regulation of PPARγ coactivator 1α (PGC-1α) signaling by an estrogen-related receptor α (ERRα) ligand

Willy, P. J., Murray, I., Qian, J., Busch, B. B., Stevens, W. C., Martin, R., Mohan, R., Zhou, S., Ordentlich, P., Wei, P. Y., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401420101 · Cited by 200

An Acetylation Switch Modulates the Transcriptional Activity of Estrogen-Related Receptor α

Wilson, B. J., Tremblay, A. M., Deblois, G., Sylvain-Drolet, G., & Giguère, V. (2010) · Molecular Endocrinology · doi:10.1210/me.2009-0441 · Cited by 192

Is bisphenol S a safe substitute for bisphenol A in terms of metabolic function? An in vitro study

Héliès‐Toussaint, C., Peyre, L., Costanzo, C., Chagnon, M., & Rahmani, R. (2014) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2014.07.025 · Cited by 192

The Transcriptional Corepressor RIP140 Regulates Oxidative Metabolism in Skeletal Muscle

Seth, A., Steel, J. H., Nichol, D., Pocock, V., Kumaran, M. K., Fritah, A., Mobberley, M. A., Ryder, T. A., Rowlerson, A. M., Scott, J., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.08.004 · Cited by 196

Skeletal muscle and nuclear hormone receptors: Implications for cardiovascular and metabolic disease

Smith, A. G., & Muscat, G. E. O. (2005) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2005.03.002 · Cited by 182

ERRγ Is Required for the Metabolic Maturation of Therapeutically Functional Glucose-Responsive β Cells

Yoshihara, E., Wei, Z., Lin, C. S., Fang, S., Ahmadian, M., Kida, Y. S., Tseng, T. W., Dai, Y. D., Yu, R. T., Liddle, C., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.03.005 · Cited by 183

The multiple universes of estrogen-related receptor α and γ in metabolic control and related diseases

Audet‐Walsh, É., & Giguère, V. (2014) · Acta Pharmacologica Sinica · doi:10.1038/aps.2014.121 · Cited by 186

Estrogen-Related Receptors as Emerging Targets in Cancer and Metabolic Disorders

Ariazi, E. A., & Jordan, V. C. (2006) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026610606030203 · Cited by 169

A Polymorphic Autoregulatory Hormone Response Element in the Human Estrogen-related Receptor α (ERRα) Promoter Dictates Peroxisome Proliferator-activated Receptor γ Coactivator-1α Control of ERRα Expression

Laganière, J., Tremblay, G. B., Dufour, C. R., Giroux, S., Rousseau, F., & Giguère, V. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313543200 · Cited by 162

Nucleus-encoded regulators of mitochondrial function: Integration of respiratory chain expression, nutrient sensing and metabolic stress

Scarpulla, R. C. (2011) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2011.10.011 · Cited by 173

Ligand Activation of ERRα by Cholesterol Mediates Statin and Bisphosphonate Effects

Wei, W., Schwaid, A. G., Wang, X., Wang, X., Chen, S., Chu, Q., Saghatelian, A., & Wan, Y. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2015.12.010 · Cited by 165

Nuclear receptors, mitochondria and lipid metabolism

Alaynick, W. A. (2008) · Mitochondrion · doi:10.1016/j.mito.2008.02.001 · Cited by 163

Estrogen-Related Receptor α Is Critical for the Growth of Estrogen Receptor–Negative Breast Cancer

Stein, R. A., Chang, C., Kazmin, D. A., Way, J. M., Schroeder, T., Wergin, M., Dewhirst, M. W., & McDonnell, D. P. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-1594 · Cited by 155

Molecular and Genetic Crosstalks between mTOR and ERRα Are Key Determinants of Rapamycin-Induced Nonalcoholic Fatty Liver

Chaveroux, C., Eichner, L. J., Dufour, C. R., Shatnawi, A. A., Khoutorsky, A., Bourque, G., Sonenberg, N., & Giguère, V. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.03.003 · Cited by 156

Cholesterol promotes EGFR-TKIs resistance in NSCLC by inducing EGFR/Src/Erk/SP1 signaling-mediated ERRα re-expression

Pan, Z., Wang, K., Wang, X., Jia, Z., Yang, Y., Duan, Y., Huang, L., Wu, Z., Zhang, J., & Ding, X. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01547-3 · Cited by 158

Identification of Diaryl Ether-Based Ligands for Estrogen-Related Receptor α as Potential Antidiabetic Agents

Patch, R. J., Searle, L. L., Kim, A. J., De, D., Zhu, X., Askari, H. B., O’Neill, J. C., Abad, M. C., Rentzeperis, D., Liu, J., et al. (2011) · Journal of Medicinal Chemistry · doi:10.1021/jm101063h · Cited by 141

Expression and Functional Study of Estrogen Receptor-Related Receptors in Human Prostatic Cells and Tissues

Cheung, C. P., Yu, S., Wong, K., Chan, L. W., Lai, F. M., Wang, X., Suetsugi, M., Chen, S., & Chan, F. L. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1421 · Cited by 136

Functional and physiological genomics of estrogen-related receptors (ERRs) in health and disease

Deblois, G., & Giguère, V. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.12.009 · Cited by 136

The NR3B Subgroup: An Overrview

Tremblay, A., & Giguère, V. (2007) · Nuclear Receptor Signaling · doi:10.1621/nrs.05009 · Cited by 134

Estrogen-Related Receptor α (ERRα) and ERRγ Are Essential Coordinators of Cardiac Metabolism and Function

Wang, T., McDonald, C., Petrenko, N. B., Leblanc, M., Wang, T., Giguère, V., Evans, R. M., Patel, V. V., & Pei, L. (2015) · Molecular and Cellular Biology · doi:10.1128/mcb.01156-14 · Cited by 134

Rat Long Chain Acyl-CoA Synthetase 5 Increases Fatty Acid Uptake and Partitioning to Cellular Triacylglycerol in McArdle-RH7777 Cells

Mashek, D. G., McKenzie, M. A., Van Horn, C. G., & Coleman, R. A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m507646200 · Cited by 129

Positive and negative control of Ucp1 gene transcription and the role of β-adrenergic signaling networks

Collins, S., Yehuda‐Shnaidman, E., & Wang, H. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.180 · Cited by 129

The Signaling Pathways Project, an integrated ‘omics knowledgebase for mammalian cellular signaling pathways

Ochsner, S. A., Abraham, D., Martin, K. A., Ding, W., McOwiti, A., Kankanamge, W. H., Wang, Z., Andreano, K. J., Hamilton, R. A., Chen, Y., et al. (2019) · Scientific Data · doi:10.1038/s41597-019-0193-4 · Cited by 119

PROTAC’ing oncoproteins: targeted protein degradation for cancer therapy

Kelm, J. M., Pandey, D. S., Malin, E., Kansou, H. W., Arora, S., Kumar, R., & Gavande, N. S. (2023) · Molecular Cancer · doi:10.1186/s12943-022-01707-5 · Cited by 122

Bisphenol A induces differentiation of human preadipocytes in the absence of glucocorticoid and is inhibited by an estrogen-receptor antagonist

Boucher, J. G., Boudreau, A., & Atlas, E. (2014) · Nutrition and Diabetes · doi:10.1038/nutd.2013.43 · Cited by 114

Estrogen-related receptor α as a therapeutic target in cancer

Stein, R. A., & McDonnell, D. P. (2006) · Endocrine Related Cancer · doi:10.1677/erc.1.01292 · Cited by 114

Receptor-Interacting Protein 140 Differentially Regulates Estrogen Receptor-Related Receptor Transactivation Depending on Target Genes

Castet‐Nicolas, A., Herlédan, A., Bonnet, S., Jalaguier, S., Vanacker, J.-M., & Cavaillès, V. (2006) · Molecular Endocrinology · doi:10.1210/me.2005-0227 · Cited by 111

Maternal high-fat intake during pregnancy programs metabolic-syndrome-related phenotypes through liver mitochondrial DNA copy number and transcriptional activity of liver PPARGC1A

Burgueño, A. L., Cabrerizo, R., Mansilla, N. G., Sookoian, S. C., & Pirola, C. J. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2011.12.008 · Cited by 110

Effects of estradiol, benzophenone-2 and benzophenone-3 on the expression pattern of the estrogen receptors (ER) alpha and beta, the estrogen receptor-related receptor 1 (ERR1) and the aryl hydrocarbon receptor (AhR) in adult ovariectomized rats

Schlecht, C., Klammer, H., Jarry, H., & Wuttke, W. (2004) · Toxicology · doi:10.1016/j.tox.2004.06.044 · Cited by 110

Chronic AMPK activation via loss of FLCN induces functional beige adipose tissue through PGC-1α/ERRαPreprint

Yan, M., Audet‐Walsh, É., Manteghi, S., Dufour, C. R., Walker, B., Baba, M., St‐Pierre, J., Giguère, V., & Pause, A. (2016) · Genes & Development · doi:10.1101/gad.281410.116 · Cited by 111

Estrogen dependent signaling in reproductive tissues—A role for estrogen receptors and estrogen related receptors

Gibson, D. A., & Saunders, P. T. K. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.09.026 · Cited by 107

Metabolic regulation by the nuclear receptor corepressor RIP140

Christian, M., White, R., & Parker, M. G. (2006) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2006.06.008 · Cited by 106

Estrogen-related Receptor α (ERRα) Is a Transcriptional Regulator of Apolipoprotein A-IV and Controls Lipid Handling in the Intestine

Carrier, J. C., Deblois, G., Champigny, C., Levy, E. H., & Giguère, V. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m410337200 · Cited by 107

Phosphorylation-Dependent Sumoylation Regulates Estrogen-Related Receptor-α and -γ Transcriptional Activity through a Synergy Control Motif

Tremblay, A., Wilson, B. J., Yang, X., & Giguère, V. (2007) · Molecular Endocrinology · doi:10.1210/me.2007-0357 · Cited by 114

Nuclear Orphan Receptor TAK1/TR4-Deficient Mice Are Protected Against Obesity-Linked Inflammation, Hepatic Steatosis, and Insulin Resistance

Kang, H. S., Okamoto, K., Kim, Y.-S., Takeda, Y., Bortner, C. D., Dang, H., Wada, T., Xie, W., Yang, X.-P., Liao, G., et al. (2010) · Diabetes · doi:10.2337/db10-0628 · Cited by 105

Molecular determinants for the polarization of macrophage and osteoclast

Yang, D., & Wan, Y. (2019) · Seminars in Immunopathology · doi:10.1007/s00281-019-00754-3 · Cited by 104

Genomic Convergence among ERRα, PROX1, and BMAL1 in the Control of Metabolic Clock Outputs

Dufour, C. R., Levasseur, M.-P., Pham, N. H. H., Eichner, L. J., Wilson, B. J., Charest-Marcotte, A., Duguay, D., Poirier-Héon, J.-F., Cermakian, N., & Giguère, V. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002143 · Cited by 107

Identification of Neuronal Enhancers of the Proopiomelanocortin Gene by Transgenic Mouse Analysis and Phylogenetic Footprinting

de Souza, F. S. J., Santangelo, A. M., Bumaschny, V. F., Avale, M. E., Smart, J. L., Low, M. J., & Rubinstein, M. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.8.3076-3086.2005 · Cited by 98

Liver X Receptor α Is a Transcriptional Repressor of the Uncoupling Protein 1 Gene and the Brown Fat Phenotype

Wang, H., Zhang, Y., Yehuda‐Shnaidman, E., Medvedev, A. V., Kumar, N., Daniel, K. W., Robidoux, J., Czech, M., Mangelsdorf, D. J., & Collins, S. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01479-07 · Cited by 101

Estrogen-Related Receptor Alpha: An Under-Appreciated Potential Target for the Treatment of Metabolic Diseases

Tripathi, M., Yen, P. M., & Singh, B. K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051645 · Cited by 98

Population whole-genome bisulfite sequencing across two tissues highlights the environment as the principal source of human methylome variation

Resource, T. M. T. H. E., Busche, S., Shao, X., Caron, M., Kwan, T., Allum, F., Cheung, W., Ge, B., Westfall, S., Simon, M.-M., et al. (2015) · Genome biology · doi:10.1186/s13059-015-0856-1 · Cited by 95

Crystal Structure of Human Estrogen-related Receptor α in Complex with a Synthetic Inverse Agonist Reveals Its Novel Molecular Mechanism

Kallen, J. A., Lattmann, R., Beerli, R., Blechschmidt, A., Blommers, M. J. J., Geiser, M., Ottl, J., Schlaeppi, J.-M., Strauss, A., & Fournier, B. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m703337200 · Cited by 96

Modulating Estrogen Receptor-related Receptor-α Activity Inhibits Cell Proliferation

Bianco, S., Lanvin, O., Tribollet, V., Macari, C., North, S., & Vanacker, J.-M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.028191 · Cited by 95

ERRα as a Bridge Between Transcription and Function: Role in Liver Metabolism and Disease

Xia, H., Dufour, C. R., & Giguère, V. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00206 · Cited by 98

Receptor Interacting Protein 140 Regulates Expression of Uncoupling Protein 1 in Adipocytes through Specific Peroxisome Proliferator Activated Receptor Isoforms and Estrogen-Related Receptor α

Debevec, D., Christian, M., Morganstein, D. L., Seth, A., Herzog, B., Parker, M. G., & White, R. (2007) · Molecular Endocrinology · doi:10.1210/me.2007-0103 · Cited by 96

Oestrogen receptor-related receptor alpha (ERRα) and oestrogen receptors (ERα and ERβ) exhibit different gene expression in human colorectal tumour progression

Cavallini, A., Notarnicola, M., Giannini, R., Montemurro, S., Lorusso, D., Visconti, A., Minervini, F., & Caruso, M. G. (2005) · European Journal of Cancer · doi:10.1016/j.ejca.2005.04.008 · Cited by 91

Esrrb, an estrogen‐related receptor involved in early development, pluripotency, and reprogramming

Festuccia, N., Owens, N. D. L., & Navarro, P. (2017) · FEBS Letters · doi:10.1002/1873-3468.12826 · Cited by 85

Orphan nuclear receptor estrogen-related receptor-β suppresses in vitro and in vivo growth of prostate cancer cells via p21WAF1/CIP1 induction and as a potential therapeutic target in prostate cancer

Yu, S., Wong, Y. C., Wang, X. H., Ling, M. T., Ng, C., Chen, S., & Chan, F. L. (2007) · Oncogene · doi:10.1038/sj.onc.1210986 · Cited by 88

Epidermal Growth Factor–Induced Signaling in Breast Cancer Cells Results in Selective Target Gene Activation by Orphan Nuclear Receptor Estrogen-Related Receptor α

Barry, J. B., & Giguère, V. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0922 · Cited by 88

Estrogen-related Receptor α Is a Repressor of Phosphoenolpyruvate Carboxykinase Gene Transcription

Herzog, B., Cardenas, J., Hall, R. K., Villena, J. A., Budge, P. J., Giguère, V., Granner, D. K., & Kralli, A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509276200 · Cited by 93

Treatment of cellulite

Khan, M., Victor, F., Rao, B. K., & Sadick, N. S. (2010) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2009.10.041 · Cited by 87

Dual Function of ERRα in Breast Cancer and Bone Metastasis Formation: Implication of VEGF and Osteoprotegerin

Fradet, A., Sorel, H., Bouazza, L., Goehrig, D., Dépalle, B., Bellahcène, A., Castronovo, V., Follet, H., Descôtes, F., Aubin, J. E., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-1431 · Cited by 87

Novel drugs that target the estrogen-related receptor alpha: their therapeutic potential in breast cancer

May, F. E. B. (2014) · Cancer Management and Research · doi:10.2147/cmar.s35024 · Cited by 91

Rosiglitazone-Induced Mitochondrial Biogenesis in White Adipose Tissue Is Independent of Peroxisome Proliferator-Activated Receptor γ Coactivator-1α

Pardo, R., Enguix, N., Lasheras, J., Felíu, J. E., Kralli, A., & Villena, J. A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026989 · Cited by 86

Eating disorder predisposition is associated with ESRRA and HDAC4 mutations

Cui, H., Moore, J., Ashimi, S. S., Mason, B. L., Drawbridge, J. N., Han, S., Hing, B. W. Q., Matthews, A. L., McAdams, C. J., Darbro, B. W., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci71400 · Cited by 85

Loss of PGC-specific expression of the orphan nuclear receptor ERR-β results in reduction of germ cell number in mouse embryos

Mitsunaga, K., Araki, K., Mizusaki, H., Morohashi, K.-I., Haruna, K., Nakagata, N., Giguère, V., Yamamura, K., & Abe, K. (2004) · Mechanisms of Development · doi:10.1016/j.mod.2004.01.006 · Cited by 85

Dysfunction of estrogen-related receptor alpha-dependent hepatic VLDL secretion contributes to sex disparity in NAFLD/NASH development

Yang, M., Liu, Q., Huang, T., Tan, W., Qu, L., Chen, T., Pan, H., Chen, L., Liu, J., Wong, C., et al. (2020) · Theranostics · doi:10.7150/thno.47037 · Cited by 88

Increased expression of estrogen‐related receptor α (ERRα) is a negative prognostic predictor in human prostate cancer

Fujimura, T., Takahashi, S., Urano, T., Kumagai, J., Ogushi, T., Horie‐Inoue, K., Ouchi, Y., Kitamura, T., Muramatsu, M., & Inoue, S. (2007) · International Journal of Cancer · doi:10.1002/ijc.22363 · Cited by 83

ERRα: a metabolic function for the oldest orphan

Villena, J. A., & Kralli, A. (2008) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2008.07.005 · Cited by 252

Divergent Role of Estrogen-Related Receptor α in Lipid- and Fasting-Induced Hepatic Steatosis in Mice

B'Chir, W., Dufour, C. R., Ouellet, C., Yan, M., Tam, I. S., Andrzejewski, S., Xia, H., Nabata, K. J., St‐Pierre, J., & Giguère, V. (2018) · Endocrinology · doi:10.1210/en.2018-00115 · Cited by 40

The estrogen-related receptor alpha: the oldest, yet an energetic orphan with robust biological functions

Ranhotra, H. S. (2010) · Journal of Receptors and Signal Transduction · doi:10.3109/10799893.2010.487493 · Cited by 50

Studying non-mammalian models? Not a fool's ERRand!

Bardet, P., Laudet, V., & Vanacker, J.-M. (2006) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2006.03.005 · Cited by 38

The nuclear Estrogen-Related receptorα (ERRα) modulates intestinal fat metabolism in mice

Carrier, J. C., & Giguère, V. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)80693-5