Cited by 327Protein Kinase Regulation and GTPase SignalingCellular transport and secretionProtein Tyrosine Phosphatases

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Signaling Specificity by Ras Family GTPases Is Determined by the Full Spectrum of Effectors They Regulate

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Rodriguez-Viciana, Pablo, Sabatier, Celine, McCormick, Frank·2004·Molecular and Cellular Biology

DOI 10.1128/mcb.24.11.4943-4954.2004PMC PMC416418

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Abstract

Ras family GTPases (RFGs) regulate signaling pathways that control multiple biological processes. How signaling specificity among the closely related family members is achieved is poorly understood. We have taken a proteomics approach to signaling by RFGs, and we have analyzed interactions of a panel of RFGs with a comprehensive group of known and potential effectors. We have found remarkable differences in the ability of RFGs to regulate the various isoforms of known effector families. We have also identified several proteins as novel effectors of RFGs with differential binding specificities to the various RFGs. We propose that specificity among RFGs is achieved by the differential regulation of combinations of effector families as well as by the selective regulation of different isoforms within an effector family. An understanding of this new level of complexity in the signaling pathways regulated by RFGs is necessary to understand how they carry out their many cellular functions. It will also likely have critical implications in the treatment of human diseases such as cancer.

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Background
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Background
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Background
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Background
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BackgroundSelf-citation
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Authors: Rodriguez-Viciana, P., Sabatier, C., & McCormick, F.
Affiliations: Cancer Research Institute and Comprehensive Cancer Center, University of California
University of California, San Francisco (US)
Corresponding author: McCormick, Frank
ORCID: McCormick, Frank
Venue: Molecular and Cellular Biology
Publisher: Informa UK Limited
Published: 2004-06
Volume: 24
Issue: 11
Pages: 4943-4954
ISSN: 0270-7306 (ISSN-L)
1098-5549
DOI: 10.1128/mcb.24.11.4943-4954.2004
PMC: PMC416418
OpenAlex: W2165023373
Cited by: 327
References: 81
Citations by year: 2026: 4 · 2025: 9 · 2024: 16 · 2023: 5 · 2022: 7 · 2021: 12 · 2020: 5 · 2019: 8 · 2018: 18 · 2017: 10 · 2016: 12 · 2015: 12 · 2014: 13 · 2013: 22 · 2012: 24
FWCI: 7.36
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Molecular and Cellular Biology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
Keywords: Ras family GTPases, signaling specificity, effector proteins, protein-protein interaction, signaling pathways, cancer
MeSH terms: Humans, Substrate Specificity, Protein Structure, Tertiary, ras Proteins, Phosphatidylinositol 3-Kinases, Proto-Oncogene Proteins c-raf, Protein Isoforms, GTP Phosphohydrolases

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Signaling Specificity by Ras Family GTPases Is Determined by the Full Spectrum of Effectors They Regulate

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