McCormick, Frank

β-Catenin regulates expression of cyclin D1 in colon carcinoma cells

Tetsu, O., & McCormick, F. (1999) · Nature

Wnt/β-catenin signaling in development and cancerSignaling Pathways in Disease

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The GTPase superfamily: conserved structure and molecular mechanism

Bourne, H. R., Sanders, D. A., & McCormick, F. (1991) · Nature

Protein Kinase Regulation and GTPase SignalingReceptor Mechanisms and Signaling

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Oncogenic Signaling Pathways in The Cancer Genome Atlas

Sanchez-Vega, F., Mina, M., Armenia, J., Chatila, W. K., Luna, A., La, K. C., Dimitriadoy, S., Liu, D. L., Kantheti, H. S., Saghafinia, S., et al. (2018) · Cell

Cancer Genomics and DiagnosticsChromatin Remodeling and Cancer

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RAS Proteins and Their Regulators in Human Disease

Simanshu, D. K., Nissley, D. V., & McCormick, F. (2017) · Cell

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

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Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition

Hangauer, M. J., Viswanathan, V. S., Ryan, M. J., Bole, D., Eaton, J. K., Matov, A., Galeas, J., Dhruv, H. D., Berens, M. E., Schreiber, S. L., et al. (2017) · Nature

Ferroptosis and cancer prognosisCancer Cells and Metastasis

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The RB and p53 pathways in cancer

Sherr, C. J., & McCormick, F. (2002) · Cancer Cell

Cancer-related Molecular PathwaysPI3K/AKT/mTOR signaling in cancer

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A Cytoplasmic Protein Stimulates Normal N- ras p21 GTPase, But Does Not Affect Oncogenic Mutants

Trahey, M., & McCormick, F. (1987) · Science

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

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RAS-targeted therapies: is the undruggable drugged?

Moore, A. R., Rosenberg, S. C., McCormick, F., & Malek, S. (2020) · Nature Reviews Drug Discovery

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

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Chromosome aberrations in solid tumors

Albertson, D. G., Collins, C., McCormick, F., & Gray, J. W. (2003) · Nature Genetics

Genomic variations and chromosomal abnormalitiesCancer Genomics and Diagnostics

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Dragging ras back in the ring

Stephen, A. G., Esposito, D., Bagni, R. K., & McCormick, F. (2014) · Cancer Cell

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

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Glutamine Sensitivity Analysis Identifies the xCT Antiporter as a Common Triple-Negative Breast Tumor Therapeutic Target

Timmerman, L. A., Holton, T., Yuneva, M., Louie, R. J., Padró, M., Daemen, A., Hu, M., Chan, D. A., Ethier, S. P., van ‘t Veer, L. J., et al. (2013) · Cancer Cell

Cancer, Hypoxia, and MetabolismAmino Acid Enzymes and Metabolism

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A role for Rho in Ras transformation

Qiu, R. G., Chen, J., McCormick, F., & Symons, M. (1995) · Proceedings of the National Academy of Sciences

Protein Kinase Regulation and GTPase SignalingCellular Mechanics and Interactions

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SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer

He, B., You, L., Uematsu, K., Zang, K., Xu, Z., Lee, A. Y., Costello, J. F., McCormick, F., & Jablons, D. M. (2003) · Proceedings of the National Academy of Sciences

Cytokine Signaling Pathways and InteractionsEpigenetics and DNA Methylation

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Signaling Specificity by Ras Family GTPases Is Determined by the Full Spectrum of Effectors They Regulate

Rodriguez-Viciana, P., Sabatier, C., & McCormick, F. (2004) · Molecular and Cellular Biology

Protein Kinase Regulation and GTPase SignalingCellular transport and secretion

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KRAS as a Therapeutic Target

McCormick, F. (2015) · Clinical Cancer Research

Protein Kinase Regulation and GTPase SignalingMelanoma and MAPK Pathways

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The metabolic landscape of RAS-driven cancers from biology to therapy

Mukhopadhyay, S., Vander Heiden, M. G., & McCormick, F. (2021) · Nature Cancer

Cancer, Hypoxia, and MetabolismProtein Kinase Regulation and GTPase Signaling

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Aurora kinase A drives the evolution of resistance to third-generation EGFR inhibitors in lung cancer

Shah, K. N., Bhatt, R., Rotow, J., Rohrberg, J., Olivas, V., Wang, V. E., Hemmati, G., Martins, M. M., Maynard, A., Kuhn, J., et al. (2019) · Nature Medicine

Lung Cancer Treatments and MutationsHER2/EGFR in Cancer Research

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Undermining Glutaminolysis Bolsters Chemotherapy While NRF2 Promotes Chemoresistance in KRAS-Driven Pancreatic Cancers

Mukhopadhyay, S., Goswami, D., Adiseshaiah, P. P., Burgan, W., Yi, M., Guerin, T. M., Kozlov, S. V., Nissley, D. V., & McCormick, F. (2020) · Cancer Research

Pancreatic and Hepatic Oncology ResearchGenomics, phytochemicals, and oxidative stress

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Ras-GTP dimers activate the Mitogen-Activated Protein Kinase (MAPK) pathway

Nan, X., Tamgüney, T. M., Collisson, E. A., Lin, L.-J., Pitt, C., Galeas, J., Lewis, S., Gray, J. W., McCormick, F., & Chu, S. (2015) · Proceedings of the National Academy of Sciences

Protein Kinase Regulation and GTPase SignalingCellular transport and secretion

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Combinatorial patterns of somatic gene mutations in cancer

Yeang, C.-H., McCormick, F., & Levine, A. (2008) · The FASEB Journal

Cancer Genomics and DiagnosticsChromatin Remodeling and Cancer

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A Phosphatase Holoenzyme Comprised of Shoc2/Sur8 and the Catalytic Subunit of PP1 Functions as an M-Ras Effector to Modulate Raf Activity

Rodriguez-Viciana, P., Oses-Prieto, J., Burlingame, A., Fried, M., & McCormick, F. (2006) · Molecular Cell

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Oncogenic and Wild-type Ras Play Divergent Roles in the Regulation of Mitogen-Activated Protein Kinase Signaling

Young, A., Lou, D., & McCormick, F. (2013) · Cancer Discovery

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K-Ras promotes tumorigenicity through suppression of non-canonical Wnt signaling

Wang, M.-T., Holderfield, M., Galeas, J., Delrosario, R., To, M. D., Balmain, A., & McCormick, F. (2015) · Cell

Protein Kinase Regulation and GTPase SignalingWnt/β-catenin signaling in development and cancer

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Differential effector engagement by oncogenic KRAS

Yuan, T. L., Amzallag, A., Bagni, R., Yi, M., Afghani, S., Burgan, W., Fer, N., Strathern, L. A., Powell, K., Smith, B., et al. (2018) · Cell Reports

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