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Cited by 380

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Gene-Targeted Mice Lacking the Trex1 (DNase III) 3′→5′ DNA Exonuclease Develop Inflammatory Myocarditis

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Morita, Masashi, Stamp, Gordon, Robins, Peter, Dulic, Anna, Rosewell, Ian, Hrivnak, Geza, Daly, Graham, Lindahl, Tomas, Barnes, Deborah E.·2004·Molecular and Cellular Biology
DOI 10.1128/mcb.24.15.6719-6727.2004
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Abstract

TREX1, originally designated DNase III, was isolated as a major nuclear DNA-specific 3'-->5' exonuclease that is widely distributed in both proliferating and nonproliferating mammalian tissues. The cognate cDNA shows homology to the editing subunit of the Escherichia coli replicative DNA polymerase III holoenzyme and encodes an exonuclease which was able to serve a DNA-editing function in vitro, promoting rejoining of a 3' mismatched residue in a reconstituted DNA base excision repair system. Here we report the generation of gene-targeted Trex1(-/-) mice. The null mice are viable and do not show the increase in spontaneous mutation frequency or cancer incidence that would be predicted if Trex1 served an obligatory role of editing mismatched 3' termini generated during DNA repair or DNA replication in vivo. Unexpectedly, Trex1(-/-) mice exhibit a dramatically reduced survival and develop inflammatory myocarditis leading to progressive, often dilated, cardiomyopathy and circulatory failure.

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Metadata

Authors
Morita, M., Stamp, G., Robins, P., Dulic, A., Rosewell, I., Hrivnak, G., Daly, G., Lindahl, T., & Barnes, D. E.
Venue
Molecular and Cellular Biology
Publisher
Informa UK Limited
Published
2004-08-01
Volume
24
Issue
15
Pages
6719-6727
ISSN
  • 0270-7306 (ISSN-L)
  • 1098-5549
DOI
10.1128/mcb.24.15.6719-6727.2004
OpenAlex
W2145812105
Cited by
380
References
4
FWCI
3.72
Type
journal article
Language
en
Open access
green
Licence
journals.asm.org/non-commercial-tdm-license (tdm)

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CoChat. (2026). Citation check: Gene-Targeted Mice Lacking the Trex1 (DNase III) 3′→5′ DNA Exonuclease Develop Inflammatory Myocarditis. https://app.cochat.ai/papers/10.1128/mcb.24.15.6719-6727.2004
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Morita, M., Stamp, G., Robins, P., Dulic, A., Rosewell, I., Hrivnak, G., Daly, G., Lindahl, T., & Barnes, D. E. (2004). Gene-Targeted Mice Lacking the Trex1 (DNase III) 3′→5′ DNA Exonuclease Develop Inflammatory Myocarditis. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.24.15.6719-6727.2004

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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