Cited by 250Peroxisome Proliferator-Activated ReceptorsCholesterol and Lipid MetabolismLipid metabolism and biosynthesis

The DOI matches its Crossref record; 72 of the 72 references it cites were found in a registry or an index.

Activated Liver X Receptors Stimulate Adipocyte Differentiation through Induction of Peroxisome Proliferator-Activated Receptor γ Expression

Open access

Seo, Jong Bae, Moon, Hyang Mi, Kim, Woo Sik, Lee, Yun Sok, Jeong, Hyun Woo, Yoo, Eung Jae, Ham, Jungyeob, Kang, Heonjoong, Park, Myoung-Gyu, Steffensen, Knut R., Stulnig, Thomas M., Gustafsson, Jan-Åke, Park, Sang Dai, Kim, Jae Bum·2004·Molecular and Cellular Biology

DOI 10.1128/mcb.24.8.3430-3444.2004PMC PMC381668

Open this paper in CoChat — free account

Abstract

Liver X receptors (LXRs) are nuclear hormone receptors that regulate cholesterol and fatty acid metabolism in liver tissue and in macrophages. Although LXR activation enhances lipogenesis, it is not well understood whether LXRs are involved in adipocyte differentiation. Here, we show that LXR activation stimulated the execution of adipogenesis, as determined by lipid droplet accumulation and adipocyte-specific gene expression in vivo and in vitro. In adipocytes, LXR activation with T0901317 primarily enhanced the expression of lipogenic genes such as the ADD1/SREBP1c and FAS genes and substantially increased the expression of the adipocyte-specific genes encoding PPARgamma (peroxisome proliferator-activated receptor gamma) and aP2. Administration of the LXR agonist T0901317 to lean mice promoted the expression of most lipogenic and adipogenic genes in fat and liver tissues. It is of interest that the PPARgamma gene is a novel target gene of LXR, since the PPARgamma promoter contains the conserved binding site of LXR and was transactivated by the expression of LXRalpha. Moreover, activated LXRalpha exhibited an increase of DNA binding to its target gene promoters, such as ADD1/SREBP1c and PPARgamma, which appeared to be closely associated with hyperacetylation of histone H3 in the promoter regions of those genes. Furthermore, the suppression of LXRalpha by small interfering RNA attenuated adipocyte differentiation. Taken together, these results suggest that LXR plays a role in the execution of adipocyte differentiation by regulation of lipogenesis and adipocyte-specific gene expression.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1128/mcb.24.8.3430-3444.2004

Cites

72 of 72 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)
Lehmann, J. M., Moore, L. B., Smith-Oliver, T. A., Wilkison, W. O., Willson, T. M., & Kliewer, S. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.22.12953 · Cited by 3,645
Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor
Tontonoz, P., Hu, E., & Spiegelman, B. M. (1994) · Cell · doi:10.1016/0092-8674(94)90006-x · Cited by 3,564
15-Deoxy-Δ12,14-Prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ
FORMAN, B. M., Tontonoz, P., Chen, J., Brun, R. P., Spiegelman, B. M., & Evans, R. M. (1995) · Cell · doi:10.1016/0092-8674(95)90193-0 · Cited by 2,857
mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer.Preprint
Tontonoz, P., Hu, E., Graves, R. A., Budavari, A. I., & Spiegelman, B. M. (1994) · Genes & Development · doi:10.1101/gad.8.10.1224 · Cited by 2,181
Nuclear Receptors and Lipid Physiology: Opening the X-Files
Chawla, A., Repa, J. J., Evans, R. M., & Mangelsdorf, D. J. (2001) · Science · doi:10.1126/science.294.5548.1866 · Cited by 2,085
PPARγ Is Required for the Differentiation of Adipose Tissue In Vivo and In Vitro
Rosen, E. D., Sarraf, P., Troy, A. E., Bradwin, G., Moore, K. J., Milstone, D. S., Spiegelman, B. M., & Mortensen, R. M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80211-7 · Cited by 2,081
A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation
Kliewer, S. A., Lenhard, J. M., Willson, T. M., Patel, I., Morris, D. C., & Lehmann, J. M. (1995) · Cell · doi:10.1016/0092-8674(95)90194-9 · Cited by 2,028
PPARγ Is Required for Placental, Cardiac, and Adipose Tissue Development
Barak, Y., Nelson, M. C., Ong, E. S., Jones, Y., Ruiz‐Lozano, P., Chien, K. R., Koder, A., & Evans, R. M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80209-9 · Cited by 1,983
Transcriptional regulation of adipogenesisPreprint
Rosen, E. D., Walkey, C. J., Puigserver, P., & Spiegelman, B. M. (2000) · Genes & Development · doi:10.1101/gad.14.11.1293 · Cited by 1,908
Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβPreprint
Repa, J. J., Liang, G., Ou, J., Bashmakov, Y. K., Lobaccaro, J. A., Shimomura, I., Shan, B., Brown, M. S., Goldstein, J. L., & Mangelsdorf, D. J. (2000) · Genes & Development · doi:10.1101/gad.844900 · Cited by 1,724

Flagged first, then by citations

Show all 72 references

Sorted by citations

Items 101–200 of 249

Potential miRNA involvement in the anti-adipogenic effect of resveratrol and its metabolites
Eseberri, I., Lasa, A., Miranda, J., Gracia, A., & Portillo, M. P. (2017) · PLoS ONE · doi:10.1371/journal.pone.0184875 · Cited by 53
Cooperative Synthesis of Ultra Long-Chain Fatty Acid and Ceramide during Keratinocyte Differentiation
Mizutani, Y., Sun, H., Ohno, Y., Sassa, T., Wakashima, T., Obara, M., Yuyama, K., Kihara, A., & Igarashi, Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067317 · Cited by 49
Hes1 stimulates transcriptional activity of Runx2 by increasing protein stabilization during osteoblast differentiation
Suh, J. H., Lee, H. W., Lee, J.-W., & Kim, J. B. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.12.100 · Cited by 47
Self-citation
Toxicogenomics in the 3T3-L1 Cell Line, a New Approach for Screening of Obesogenic Compounds
Pereira-Fernandes, A., Vanparys, C., Vergauwen, L., Knapen, D., Jorens, P. G., & Blust, R. (2014) · Toxicological Sciences · doi:10.1093/toxsci/kfu092 · Cited by 47
Cholesterol-Sensing Receptors, Liver × Receptor α and β, Have Novel and Distinct Roles in Osteoclast Differentiation and Activation
Robertson, K. M.-P., Norgård, M., Windahl, S. H., Hultenby, K. R., Ohlsson, C., Andersson, G. N., & Gustafsson, J.-Α. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.060503 · Cited by 47
Self-citation
Hepatic PPARγ and LXRα independently regulate lipid accumulation in the livers of genetically obese mice
Matsusue, K., Aibara, D., Hayafuchi, R., Matsuo, K., Takiguchi, S., Gonzalez, F. J., & Yamano, S. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.05.012 · Cited by 46
Docosahexaenoic acid regulates serum amyloid A protein to promote lipolysis through down regulation of perilipin
Wang, Y. C., Kuo, W., Chen, C., Lin, H., Wu, H. T., Liu, B. H., Chen, C. H., Mersmann, H. J., Chang, K., & Ding, S. (2009) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2009.01.004 · Cited by 48
Hyperinsulinemia Induces Insulin Resistance on Glucose and Lipid Metabolism in a Human Adipocytic Cell Line: Paracrine Interaction with Myocytes
Fernández‐Veledo, S., Nieto-Vázquez, I., de Castro, J., Ramos, P., Brüderlein, S., Möller, P., & Lorenzo, M. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2472 · Cited by 45
Kaempferol Isolated from Nelumbo nucifera Inhibits Lipid Accumulation and Increases Fatty Acid Oxidation Signaling in Adipocytes
Lee, B., Kwon, M., Choi, J. S., Jeong, H. O., Chung, H. Y., & Kim, H. (2015) · Journal of Medicinal Food · doi:10.1089/jmf.2015.3457 · Cited by 44
Self-citation
Morin, a novel liver X receptor α/β dual antagonist, has potent therapeutic efficacy for nonalcoholic fatty liver diseases
Gu, M., Zhang, Y., Liu, C., Wang, D., Li, F., Fan, S., Yang, B., Tong, Q., Ji, G., & Huang, C. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13933 · Cited by 43
Revisiting the Role of LXRs in PUFA Metabolism and Phospholipid Homeostasis
Jalil, A., Bourgeois, T., Ménégaut, L., Lagrost, L., Thomas, C., & Masson, D. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20153787 · Cited by 44
Daily rhythms of lipid metabolic gene expression in zebra fish liver: Response to light/dark and feeding cycles
Paredes, J. F., López‐Olmeda, J. F., Martínez, F. J. S., & Sánchez‐Vázquez, F. J. (2015) · Chronobiology International · doi:10.3109/07420528.2015.1104327 · Cited by 44
Cold-sensing TRPM8 channel participates in circadian control of the brown adipose tissue
Moraes, M. N., de Assis, L. V. M., Henriques, F. D. S., Júnior, M. L. B., Güler, A. D., & Castrucci, A. M. D. L. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2017.09.011 · Cited by 41
Benzyl Isothiocyanate and Phenethyl Isothiocyanate Inhibit Adipogenesis and Hepatosteatosis in Mice with Obesity Induced by a High-Fat Diet
Chuang, W.-T., Liu, Y.-T., Huang, C., Lo, C., Yao, H., Chen, H., & Lii, C. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b02668 · Cited by 42
Comparison of skeletal and soft tissue pericytes identifies CXCR4+ bone forming mural cells in human tissues
Xu, J., Li, D., Hsu, C.-Y., Tian, Y. E., Zhang, L., Wang, Y., Tower, R. J., Chang, L., Meyers, C. A., Gao, Y., et al. (2020) · Bone Research · doi:10.1038/s41413-020-0097-0 · Cited by 42
Gene Expression Patterns Associated with Peroxisome Proliferator-activated Receptor (PPAR) Signaling in the Longissimus dorsi of Hanwoo (Korean Cattle)
Lim, D., Chai, H., Lee, S. H., Cho, Y.-M., Choi, J.-W., & Kim, N.-K. (2015) · Asian-Australasian Journal of Animal Sciences · doi:10.5713/ajas.14.0811 · Cited by 41
LXRα activation perturbs hepatic insulin signaling and stimulates production of apolipoprotein B-containing lipoproteins
Basciano, H., Miller, A., Baker, C., Naples, M., & Adeli, K. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90546.2008 · Cited by 40
Cloning and Characterization of Lxr and Srebp1, and Their Potential Roles in Regulation of LC‐PUFA Biosynthesis in Rabbitfish Siganus canaliculatus
Zhang, Q., You, C., Liu, F., Zhu, W., Wang, S., Xie, D., Monroig, Ó., Tocher, D. R., & Li, Y. (2016) · Lipids · doi:10.1007/s11745-016-4176-3 · Cited by 39
Examination of nuclear receptor expression in osteoblasts reveals rorβ as an important regulator of osteogenesis
Roforth, M. M., Liu, G., Khosla, S., & Monroe, D. G. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1502 · Cited by 40
Genetics of sexually dimorphic adipose distribution in humans
Hansen, G. T., Sobreira, D. R., Weber, Z., Thornburg, A. G., Aneas, I., Zhang, L., Sakabe, N. J., Joslin, A. C., Haddad, G. A., Strobel, S., et al. (2023) · Nature Genetics · doi:10.1038/s41588-023-01306-0 · Cited by 38
Group X secretory phospholipase A 2 negatively regulates adipogenesis in murine models
Li, X., Shridas, P., Forrest, K. J., Bailey, W. M., & Webb, N. R. (2010) · The FASEB Journal · doi:10.1096/fj.10-154716 · Cited by 39
Role of LXR in trout adipocytes: Target genes, hormonal regulation, adipocyte differentiation and relation to lipolysis
Cruz-Garcia, L., Sánchez-Gurmaches, J., Gutiérrez, J., & Navarro, I. (2012) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2012.05.193 · Cited by 40
Novel Insights into Adipogenesis from Omics Data
Prokesch, A., Hackl, H., Hakim-Weber, R., Bornstein, S. R., & Trajanoski, Z. (2009) · Current Medicinal Chemistry · doi:10.2174/092986709788803132 · Cited by 38
Synthesis and Secretion of ApoC-I and ApoE during Maturation of Human SW872 Liposarcoma Cells
Wassef, H., Bernier, L., Davignon, J., & Cohn, J. S. (2004) · Journal of Nutrition · doi:10.1093/jn/134.11.2935 · Cited by 37
Liver X receptors as regulators of metabolism
Korach-André, M., & Gustafsson, J.-Α. (2015) · BioMolecular Concepts · doi:10.1515/bmc-2015-0007 · Cited by 40
Self-citation
Liver X Receptor Ligands Suppress Ubiquitination and Degradation of LXRα by Displacing BARD1/BRCA1
Kim, K. H., Yoon, J. M., Choi, A. H., Kim, W. S., Lee, G. Y., & Kim, J. B. (2009) · Molecular Endocrinology · doi:10.1210/me.2008-0295 · Cited by 41
Self-citation
High expression of liver histone deacetylase 3 contributes to high-fat-diet-induced metabolic syndrome by suppressing the PPAR-γ and LXR-α-pathways in E3 rats
Li, D., Wang, X., Ren, W., Ren, J., Lan, X., Wang, F., Li, H., Zhang, F., Han, Y., Song, T., et al. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.06.028 · Cited by 37
Adipose and non-adipose perspectives of plant derived natural compounds for mitigation of obesity
Borah, A. K., Sharma, P., Singh, A., Kalita, K. J., Saha, S., & Borah, J. C. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114410 · Cited by 35
Visceral Obesity is Associated with High Levels of Serum Squalene
Peltola, P., Pihlajamäki, J., Koutníková, H., Ruotsalainen, E., Salmenniemi, U., Vauhkonen, I., Kainulainen, S., Gylling, H. K., Miettinen, T. A., Auwerx, J. H., et al. (2006) · Obesity · doi:10.1038/oby.2006.132 · Cited by 35
Antiadipogenic Effects ofAster glehniExtract: In Vivo and In Vitro Effects
Lee, H.-M., Yang, G., Ahn, T.-G., Kim, M.-D., Nugroho, A., Park, H.-J., Lee, K., Park, W., & An, H. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/859624 · Cited by 35
Nuclear Receptors and Clearance of Apoptotic Cells: Stimulating the Macrophage’s Appetite
A-González, N., & Hidalgo, A. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00211 · Cited by 34
MicroRNA-192* impairs adipocyte triglyceride storage
Mysore, R., Zhou, Y., Sädevirta, S., Savolainen-Peltonen, H. M., Haridas, P. A. N., Soronen, J., Leivonen, M., Sarin, A., Fischer‐Posovszky, P., Wabitsch, M., et al. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2015.12.019 · Cited by 34
Palmitic acid-induced apoptosis in pancreatic β-cells is increased by liver X receptor agonist and attenuated by eicosapentaenoate.
Liang, H., Zhong, Y., Zhou, S., & Li, Q. Q. (2011) · PubMed · Cited by 34
Regulation of Insulin Resistance and Adiponectin Signaling in Adipose Tissue by Liver X Receptor Activation Highlights a Cross-Talk with PPARγ
Zheng, F., Zhang, S., Lu, W., Wu, F., Yin, X., Yu, D., Pan, Q., & Li, H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0101269 · Cited by 32
Group X Secretory Phospholipase A2 Regulates the Expression of Steroidogenic Acute Regulatory Protein (StAR) in Mouse Adrenal Glands
Shridas, P., Bailey, W. M., Boyanovsky, B. B., Oslund, R., Gelb, M. H., & Webb, N. R. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.090423 · Cited by 32
SYNERGISTIC EFFECT OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR-γ AND LIVER X RECEPTOR-α IN THE REGULATION OF INFLAMMATION IN MACROPHAGES
Piraino, G., Cook, J. A., O’Connor, M. P., Hake, P. W., Burroughs, T. J., Teti, D. V., & Zingarelli, B. (2006) · Shock · doi:10.1097/01.shk.0000223121.03523.69 · Cited by 32
Rationale and design of a prospective clinical trial program to evaluate the glucose-lowering effects of colesevelam HCl in patients with type 2 diabetes mellitus
Bays, H. E., & Cohen, D. E. (2007) · Current Medical Research and Opinion · doi:10.1185/030079907x210525 · Cited by 32
Foenumoside B from Lysimachia foenum-graecum inhibits adipocyte differentiation and obesity induced by high-fat diet
Seo, J. B., Park, S. W., Choe, S. S., Jeong, H. W., Park, J. Y., Choi, E.-W., Seen, D., Jeong, J.-Y., & Lee, T. G. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.12.039 · Cited by 31
Self-citation
Chromatin accessibility and gene expression during adipocyte differentiation identify context-dependent effects at cardiometabolic GWAS loci
Perrin, H. J., Currin, K. W., Vadlamudi, S., Pandey, G. K., Ng, K. K. H., Wabitsch, M., Laakso, M., Love, M. I., & Mohlke, K. L. (2021) · PLoS Genetics · doi:10.1371/journal.pgen.1009865 · Cited by 29
Gene expression profiling of 3T3-L1 adipocytes exposed to phloretin
Hassan, M., Yazidi, C. E., Malezet‐Desmoulins, C., Amiot, M. J., & Margotat, A. (2009) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2009.04.006 · Cited by 31
Vitronectin-Based, Biomimetic Encapsulating Hydrogel Scaffolds Support Adipogenesis of Adipose Stem Cells
Clevenger, T. N., Hinman, C., Rubin, R. K. A., Smither, K., Burke, D. J., Hawker, C. J., Messina, D. J., Epps, D. V., & Clegg, D. (2016) · Tissue Engineering Part A · doi:10.1089/ten.tea.2015.0550 · Cited by 30
Berberine-Improved Visceral White Adipose Tissue Insulin Resistance Associated with Altered Sterol Regulatory Element-Binding Proteins, Liver X Receptors, and Peroxisome Proliferator-Activated Receptors Transcriptional Programs in Diabetic Hamsters
Li, G., Liu, X., Zhu, H., Huang, L. J., Liu, Y., Ma, C., & Qin, C. (2011) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.34.644 · Cited by 30
PPARs in Alveolar Macrophage Biology
Smith, M. R., Standiford, T. J., & Reddy, R. C. (2007) · PPAR Research · doi:10.1155/2007/23812 · Cited by 27
Blood Glucose-Lowering Nuclear Receptor Agonists Only Partially Normalize Hepatic Gene Expression in db/db Mice
Löffler, M. G., Bilban, M., Reimers, M., Waldhäusl, W. K., & Stulnig, T. M. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.093831 · Cited by 31
Self-citation
Citrate carrier promoter is target of peroxisome proliferator-activated receptor alpha and gamma in hepatocytes and adipocytes
Damiano, F., Gnoni, G. V., & Siculella, L. (2012) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2012.01.003 · Cited by 27
Adipocyte fatty acid-binding protein (aP2), a newly identified LXR target gene, is induced by LXR agonists in human THP-1 cells
Liu, Q.-Y., Quinet, E. M., & Nambi, P. (2007) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-007-9442-5 · Cited by 27
Metformin Ameliorates Hepatic Steatosis induced by olanzapine through inhibiting LXRα/PCSK9 pathway
Zhu, W., Ding, C., Huang, P., Ran, J., Lian, P., Tang, Y., Dai, W., & Huang, X. (2022) · Scientific Reports · doi:10.1038/s41598-022-09610-1 · Cited by 27
LXRα fuels fatty acid-stimulated oxygen consumption in white adipocytes
Dib, L. H., Bugge, A. K., & Collins, S. (2013) · Journal of Lipid Research · doi:10.1194/jlr.m043422 · Cited by 26
Rose hip exerts antidiabetic effects via a mechanism involving downregulation of the hepatic lipogenic program
Andersson, U., Henriksson, E., Ström, K., Alenfall, J., Göransson, O., & Holm, C. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00268.2010 · Cited by 27
Protein kinase CK2 is necessary for the adipogenic differentiation of human mesenchymal stem cells
Schwind, L., Wilhelm, N., Kartarius, S., Montenarh, M., Gorjup, E., & Götz, C. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.05.023 · Cited by 26
Aberrant activation of liver X receptors impairs pancreatic beta cell function through upregulation of sterol regulatory element-binding protein 1c in mouse islets and rodent cell lines
Meng, Z., Yin, Y., Lv, J., Sha, M., Lin, Y., Gao, L., Zhu, Y., Sun, Y., & Han, X. (2012) · Diabetologia · doi:10.1007/s00125-012-2516-2 · Cited by 26
Expression of the LXRα Protein in Human Atherosclerotic Lesions
Watanabe, Y., Jiang, S. S., Takabe, W., Ohashi, R., Tanaka, T., Uchiyama, Y., Katsumi, K., Iwanari, H., Noguchi, N., Naito, M., et al. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000154489.53077.4e · Cited by 27
SIRT7 regulates lipogenesis in adipocytes through deacetylation of PPARγ2
Akter, F., Tsuyama, T., Yoshizawa, T., Sobuz, S. U., & Yamagata, K. (2021) · Journal of Diabetes Investigation · doi:10.1111/jdi.13567 · Cited by 25
Honokiol enhances adipocyte differentiation by potentiating insulin signaling in 3T3-L1 preadipocytes
Choi, S., Cha, B., Iida, K., Sato, M., Lee, Y., Teruya, T., Yonezawa, T., Nagai, K., & Woo, J. (2011) · Journal of Natural Medicines · doi:10.1007/s11418-011-0512-3 · Cited by 26
Self-citation
22‐S‐Hydroxycholesterol protects against ethanol‐induced liver injury by blocking the auto/paracrine activation of MCP ‐1 mediated by LXRα
Na, T., Han, Y., Ka, N., Park, H., Kang, Y. P., Kwon, S. W., Lee, B., & Lee, M. (2014) · The Journal of Pathology · doi:10.1002/path.4494 · Cited by 25
Identification of a novel agonist of peroxisome proliferator-activated receptors α and γ that may contribute to the anti-diabetic activity of guggulipid in Lep/Lep mice
Cornick, C., Strongitharm, B. H., Sassano, G., Rawlins, C., Mayes, A. E., Joseph, A. N., O’Dowd, J. F., Stocker, C. J., Wargent, E. T., Cawthorne, M. A., et al. (2008) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2008.07.010 · Cited by 24
Natural and Synthetic PPARγ Ligands in Tumor Microenvironment: A New Potential Strategy against Breast Cancer
Augimeri, G., Gelsomino, L., Plastina, P., Giordano, C., Barone, I., Catalano, S., Andò, S., & Bonofiglio, D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249721 · Cited by 26
Colesevelam hydrochloride: reducing atherosclerotic coronary heart disease risk factors.
Bays, H. E., & Jones, P. H. (2007) · PubMed Central · Cited by 24
Glucosylceramide synthase regulates adipo‐osteogenic differentiation through synergistic activation of PPARγ with GlcCer
Jang, H., Lim, S., Kim, J., Yoon, S., Lee, C. Y., Hwang, H., Shin, J. W., Shin, K. J., Kim, H. Y., Park, K., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201901437r · Cited by 22
Self-citation
Guardian of corpulence: a hypothesis on p53 signaling in the fat cell
Bazuine, M., Stenkula, K. G., Cam, M., Arroyo, M., & Cushman, S. W. (2009) · Clinical Lipidology · doi:10.2217/clp.09.2 · Cited by 21
The WNT/β-catenin pathway is involved in the anti-adipogenic activity of cerebrosides from the sea cucumber Cucumaria frondosa
Xu, H., Wang, F., Wang, J., Xu, J., Wang, Y., & Xue, C. (2015) · Food & Function · doi:10.1039/c5fo00273g · Cited by 22
Wrestling Rules in Transrepression: As Easy as SUMO-1, -2, -3?
Treuter, E., & Gustafsson, J.-Å. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.01.009 · Cited by 21
Self-citation
Ochratoxin A Inhibits Adipogenesis Through the Extracellular Signal-Related Kinases–Peroxisome Proliferator-Activated Receptor-γ Pathway in Human Adipose Tissue-Derived Mesenchymal Stem Cells
Lim, S., Jang, H., Kim, J. K., Kim, J., Park, E. H., Yang, J. H., Kim, Y., Yea, K., Ryu, S. H., & Suh, P. (2010) · Stem Cells and Development · doi:10.1089/scd.2010.0071 · Cited by 21
Self-citation
Isolation and morphological characterization of ovine amniotic fluid mesenchymal stem cells
Tian, Y., Tao, L., Zhao, S., Tai, D., Liu, D., & Liu, P. (2015) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.15-0031 · Cited by 20
Knockdown of LXRα Inhibits Goat Intramuscular Preadipocyte Differentiation
Xiong, Y., Xu, Q., Lin, S., Wang, Y., Lin, Y., & Zhu, J. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103037 · Cited by 20
ChREBP and LXRα mediate synergistically lipogenesis induced by glucose in porcine adipocytes
Zhang, G. H., Lu, J. X., Chen, Y., Guo, P. H., Qiao, Z. L., Feng, R., Chen, S. E., Bai, J. L., Huo, S. D., & Ren, Z. (2015) · Gene · doi:10.1016/j.gene.2015.03.057 · Cited by 19
Mechanisms of divergent effects of activated peroxisome proliferator-activated receptor-γ on mitochondrial citrate carrier expression in 3T3-L1 fibroblasts and mature adipocytes
Bonofiglio, D., Santoro, A., Martello, E., Vizza, D., Rovito, D., Cappello, A. R., Barone, I., Giordano, C., Panza, S., Catalano, S., et al. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.01.014 · Cited by 19
Increasing adipocyte number and reducing adipocyte size: the role of retinoids in adipose tissue development and metabolism
Wang, B., & Du, ‬. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2227258 · Cited by 20
Bile acid signaling to the nucleus: finding new connections in the transcriptional regulation of metabolic pathways
Fabiani, E. D., Mitro, N., Godio, C., Gilardi, F., Caruso, D., & Crestani, M. (2004) · Biochimie · doi:10.1016/j.biochi.2004.09.027 · Cited by 18
PPARgamma: A Potential Intrinsic and Extrinsic Molecular Target for Breast Cancer Therapy
Augimeri, G., & Bonofiglio, D. (2021) · Biomedicines · doi:10.3390/biomedicines9050543 · Cited by 17
Activation of LXRα induces lipogenesis in HaCaT cells
Hong, I., Rho, H. S., Kim, D., & Lee, M. (2010) · Archives of Pharmacal Research · doi:10.1007/s12272-010-0919-5 · Cited by 17
Biochemical and histopathological effects of dietary oxidized cholesterol in rats
Soto-Rodríguez, I., Campillo‐Velázquez, P. J., Alexander-Aguilera, A., Rodríguez‐Estrada, M. T., Lercker, G., & Garcia, H. S. (2009) · Journal of Applied Toxicology · doi:10.1002/jat.1463 · Cited by 17
The orphan nuclear receptor DAX-1 acts as a novel transcriptional corepressor of PPARγ
Kim, G. S., Lee, G. Y., Nedumaran, B., Park, Y., Kim, K. T., Park, S. C., Lee, Y. C., Kim, J. B., & Choi, H. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.03.098 · Cited by 16
Self-citation
High-Fructose Intake Impairs the Hepatic Hypolipidemic Effects of a High-Fat Fish-Oil Diet in C57BL/6 Mice
Wooten, J. S., Nick, T. N., Seija, A., Poole, K. E., & Stout, K. B. (2016) · Journal of Clinical and Experimental Hepatology · doi:10.1016/j.jceh.2016.09.001 · Cited by 16
Nodakenin represses obesity and its complications via the inhibition of the VLDLR signalling pathway in vivo and in vitro
Jin, B., Lee, M., & An, H. (2021) · Cell Proliferation · doi:10.1111/cpr.13083 · Cited by 16
Antioxidant-rich Tamarindus indica L. leaf extract reduced high-fat diet-induced obesity in rat through modulation of gene expression
Kuddus, S. A., Bhuiyan, M. I., Subhan, N., Shohag, M. H., Rahman, A. S. M. Z., Hossain, M., Alam, M. A., & Khan, F. (2020) · Clinical Phytoscience · doi:10.1186/s40816-020-00213-9 · Cited by 15
Deoxynivalenol Exposure Suppresses Adipogenesis by Inhibiting the Expression of Peroxisome Proliferator-Activated Receptor Gamma 2 (PPARγ2) in 3T3-L1 Cells
Zhao, Y., Tang, S., Lin, R., Zheng, T., Li, D., Chen, X., Zhu, J., Wen, J., & Deng, Y. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176300 · Cited by 15
An RNAi Screening of Clinically Relevant Transcription Factors Regulating Human Adipogenesis and Adipocyte Metabolism
Björk, C., Subramanian, N., Liu, J., Acosta, J. R., Tavira, B., Eriksson, A. B., Arner, P., & Laurencikiene, J. (2021) · Endocrinology · doi:10.1210/endocr/bqab096 · Cited by 16
Microarray Evidences the Role of Pathologic Adipose Tissue in Insulin Resistance and Their Clinical Implications
Mathur, S. K., Jain, P., & Mathur, P. (2011) · Journal of Obesity · doi:10.1155/2011/587495 · Cited by 15
Selective LXRα inhibitory effects observed in plant extracts of MEH184 (Parthenocissua tricuspidata) and MEH185 (Euscaphis japonica)
Kim, K. H., Choi, S. H., Lee, T. S., Oh, W. K., Kim, D. S., & Kim, J. B. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.08.092 · Cited by 18
Self-citation
Osteoinductive effects of glyceollins on adult mesenchymal stromal/stem cells from adipose tissue and bone marrow
Bateman, M. E., Strong, A. L., Hunter, R. S., Bratton, M. R., Komati, R., Sridhar, J., Riley, K. E., Wang, G., Hayes, D. J., Boué, S. M., et al. (2017) · Phytomedicine · doi:10.1016/j.phymed.2017.02.003 · Cited by 14
Geranylgeranyl pyrophosphate performs as an endogenous regulator of adipocyte function via suppressing the LXR pathway
Yeh, Y., Goto, T., Takahashi, N., Egawa, K., Takahashi, H., Jheng, H., Kim, Y., & Kawada, T. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.08.119 · Cited by 14
[Obesity, inflammation and diabetes].
Miranda-Garduño, L. M., & Reza‐Albarrán, A. (2008) · PubMed · Cited by 14
Dietary oleic acid drives obesogenic adipogenesis via modulation of LXRα signaling
Wing, A., Jeffery, E. C., CHURCH, C. D., Goodell, J., Saavedra-Peña, R. D. M., Saha, M., Holtrup, B., Voisin, M., Alavi, N. S., Floody, M., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115527 · Cited by 15
Transcriptome analysis of hen preadipocytes treated with an adipogenic cocktail (DMIOA) with or without 20(S)-hydroxylcholesterol
Regassa, A., & Kim, W. K. (2015) · BMC Genomics · doi:10.1186/s12864-015-1231-z · Cited by 14
Self-citation
Thermogenic Fat as a New Obesity Management Tool: From Pharmaceutical Reagents to Cell Therapies
Cheng, Y., Liang, S., Zhang, S., & Hui, X. H. (2024) · Biomedicines · doi:10.3390/biomedicines12071474 · Cited by 13
An Update on the Metabolic Landscape of Oncogenic Viruses
Gaballah, A. H., & Bartosch, B. (2022) · Cancers · doi:10.3390/cancers14235742 · Cited by 13
Lipid signaling in the atherogenesis context
Smirnov, A. N. (2010) · Biochemistry (Moscow) · doi:10.1134/s0006297910070011 · Cited by 12
Association of combined genetic variations in PPARγ, PGC-1α, and LXRα with coronary artery disease and severity in Thai population
Yongsakulchai, P., Settasatian, C., Settasatian, N., Komanasin, N., Kukongviriyapan, U., Coté, M. L., Intharapetch, P., & Senthong, V. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2016.03.005 · Cited by 13
Glucose and Insulin Stimulate Lipogenesis in Porcine Adipocytes: Dissimilar and Identical Regulation Pathway for Key Transcription Factors
Hua, Z. G., Xiong, L. J., Chen, Y., Wei, D. H., YingPai, Z., Qing, Z. Y., Lin, Q., Fei, F. R., Ling, W. Y., & Ren, M. Z. (2016) · Molecules and Cells · doi:10.14348/molcells.2016.0144 · Cited by 13
Critical roles of transcriptional coactivator MED1 in the formation and function of mouse adipose tissuesPreprint
Ito, K., Schneeberger, M., Gerber, A., Jishage, M., Marchildon, F., Maganti, A. V., Cohen, P., Friedman, J. M., & Roeder, R. G. (2021) · Genes & Development · doi:10.1101/gad.346791.120 · Cited by 13
Myeloid Elf‐1‐like factor stimulates adipogenic differentiation through the induction of peroxisome proliferator‐activated receptor γ expression in bone marrow
Baek, K., Cho, J., Hwang, H. R., Kwon, A., Lee, H., Park, H., Qadir, A. S., Ryoo, H., Woo, K. M., & Baek, J. (2012) · Journal of Cellular Physiology · doi:10.1002/jcp.24064 · Cited by 12
Proteome analysis in adipose tissue of ob/ob mice in response to chitosan oligosaccharides treatment
Rahman, M. A., Kumar, S. G., & Yun, J. W. (2010) · Biotechnology and Bioprocess Engineering · doi:10.1007/s12257-009-3135-8 · Cited by 12
The Antagonist Effect of Arachidonic Acid on GLUT4 Gene Expression by Nuclear Receptor Type II Regulation
Moreno‐Santos, I., García‐Serrano, S., Boughanem, H., Garrido‐Sánchez, L., Tinahones, F. J., García‐Fuentes, E., & Macías‐González, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20040963 · Cited by 12
Effects of Vitamin A on Yanbian Yellow Cattle and Their Preadipocytes by Activating AKT/mTOR Signaling Pathway and Intestinal Microflora
Zhang, X., Xu, H., Zhang, C., Bai, J., Ji-xuan, S., Hao, B., Zhang, L., & Xia, G. (2022) · Animals · doi:10.3390/ani12121477 · Cited by 12
Time-dependent alterations in mRNA, protein and microRNA during in vitro adipogenesis
Krishna, M. S., Kumar, A. A., & Jaleel, A. (2018) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-018-3307-y · Cited by 11
CNX-013-B2, a unique pan tissue acting rexinoid, modulates several nuclear receptors and controls multiple risk factors of the metabolic syndrome without risk of hypertriglyceridemia, hepatomegaly and body weight gain in animal models
Sadasivuni, M. K., Reddy, B. M., Singh, J. K., Oommen, A. M., Venkategowda, S., Lakshmi, M. N., Yogeshwari, S., Chacko, S. K., Pooja, T. L., Dandu, A., et al. (2014) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-6-83 · Cited by 11
Differential interactions of antiretroviral agents with LXR , ER and GR nuclear receptors: potential contributing factors to adverse events
Svärd, J., Blanco, F., Nevin, D. K., Fayne, D., Mulcahy, F. M., Hennessy, M., & Spiers, P. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12480 · Cited by 11
A Nonthiazolidinedione Peroxisome Proliferator-Activated Receptor α/γ Dual Agonist CG301360 Alleviates Insulin Resistance and Lipid Dysregulation in db/db Mice
Jeong, H. W., Lee, J.-W., Kim, W. S., Choe, S. S., Shin, H. J., Lee, G. Y., Shin, D., Lee, J. H., Choi, E. B., Lee, H., et al. (2010) · Molecular Pharmacology · doi:10.1124/mol.110.065748 · Cited by 9
Self-citation
Transcriptional regulation of peroxisome proliferator-activated receptors and liver X receptors
Villacorta, L., Garcia-Barrio, M. T., & Chen, Y. E. (2007) · Current Atherosclerosis Reports · doi:10.1007/s11883-007-0024-5 · Cited by 9

Authors: Seo, J. B., Moon, H. M., Kim, W. S., Lee, Y. S., Jeong, H. W., Yoo, E. J., Ham, J., Kang, H., Park, M.-G., Steffensen, K. R., Stulnig, T. M., Gustafsson, J.-Å., Park, S. D., & Kim, J. B.
Affiliations: Seoul National University (KR)
MDBioAlpha R&D Center
Karolinska Institutet (SE)
Department of Biosciences at Novum, Karolinska Institutet
International Vaccine Institute (KR)
Corresponding author: Kim, Jae Bum
ORCID: Seo, Jong Bae
Moon, Hyang Mi
Kim, Woo Sik
Lee, Yun Sok
Jeong, Hyun Woo
Ham, Jungyeob
Kang, Heonjoong
Steffensen, Knut R.
Stulnig, Thomas M.
Kim, Jae Bum
Venue: Molecular and Cellular Biology
Publisher: Informa UK Limited
Published: 2004-04
Volume: 24
Issue: 8
Pages: 3430-3444
ISSN: 0270-7306 (ISSN-L)
1098-5549
DOI: 10.1128/mcb.24.8.3430-3444.2004
PMC: PMC381668
OpenAlex: W2100448400
Cited by: 250
References: 72
Citations by year: 2026: 1 · 2025: 5 · 2024: 5 · 2023: 5 · 2022: 4 · 2021: 10 · 2020: 5 · 2019: 9 · 2018: 9 · 2017: 7 · 2016: 11 · 2015: 16 · 2014: 16 · 2013: 18 · 2012: 11
FWCI: 6.88
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Molecular and Cellular Biology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Keywords: liver X receptor, adipogenesis, PPARγ, T0901317, lipogenesis, SREBP-1c, Fas, AP-2, histone H3 acetylation, liver X receptor alpha, nuclear receptors, transcriptional regulation
MeSH terms: Liver X Receptors, Adipose Tissue, Animals, Cell Differentiation, Cells, Cultured, DNA-Binding Proteins, Gene Expression Regulation, Humans, Liver, Promoter Regions, Genetic, Protein Binding, RNA, Messenger, Transcription Factors, Stromal Cells, Adipocytes, Receptors, Cytoplasmic and Nuclear, Oligonucleotide Array Sequence Analysis, CCAAT-Enhancer-Binding Proteins, RNA, Small Interfering, Mice, Sterol Regulatory Element Binding Protein 1, Orphan Nuclear Receptors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Activated Liver X Receptors Stimulate Adipocyte Differentiation through Induction of Peroxisome Proliferator-Activated Receptor γ Expression

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks