A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation
Open accessAbstract
Prostaglandins (PGs) of the J2 series form in vivo and exert effects on a variety of biological processes. While most of PGs mediate their effects through G protein-coupled receptors, the mechanism of action for the J2 series of PGs remains unclear. Here, we report the PGJ2 and its derivatives are efficacious activators of peroxisome proliferator-activated receptors alpha and gamma (PPAR alpha and PPAR gamma, respectively), orphan nuclear receptors implicated in lipid homeostasis and adipocyte differentiation. The PGJ2 metabolite 15-deoxy-delta 12,14-PGJ2 binds directly to PPAR gamma and promotes efficient differentiation of C3H10T1/2 fibroblasts to adipocytes. These data provide strong evidence that a fatty acid metabolite can function as an adipogenic agent through direct interactions with PPAR gamma and furthermore, suggest a novel mechanism of action for PGs of the J2 series.
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P. acnes and its soluble factors may participate in the augmentation of sebaceous lipogenesis by increasing the production of 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2), an endogenous activator of PPARγ.
“Interestingly, P. acnes and its soluble factors may also participate in the augmentation of sebaceous lipogenesis by increasing the production of the 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2), an endogenous activator of PPARγ.74”
From Sebaceous-immunobiology is orchestrated by sebum lipids (2017) · cites this paper as [74]
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“Furthermore, PPAR-a seems to be related to b-oxidation of fatty acids and lipid catabolism.73 Interestingly, P. acnes and its soluble factors may also participate in the augmentation of sebaceous lipogenesis by increasing the production of the 15-deoxyD12,14-prostaglandin J2 (15d-PGJ2), an endogenous activator of PPAR…”
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- Authors
- Kliewer, S. A., Lenhard, J. M., Willson, T. M., Patel, I., Morris, D. C., & Lehmann, J. M.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1995-12
- Volume
- 83
- Issue
- 5
- Pages
- 813-819
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2050717908
- Cited by
- 2,028
- References
- 2
- Citations by year
- 2026: 8 · 2025: 15 · 2024: 15 · 2023: 16 · 2022: 23 · 2021: 26 · 2020: 20 · 2019: 31 · 2018: 38 · 2017: 19 · 2016: 35 · 2015: 34 · 2014: 38 · 2013: 50 · 2012: 66
- FWCI
- 34.67
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Keywords
- prostaglandin J2, 15-deoxy-Δ12,14-prostaglandin J2, PPARγ, PPARα, adipogenesis, nuclear receptor activation, C3H10T1/2 fibroblasts, fatty acid metabolites, mechanism of action, lipid homeostasis
- MeSH terms
- Rosiglitazone, Animals, Binding, Competitive, Cell Differentiation, Cells, Cultured, Fibroblasts, Hypoglycemic Agents, Ligands, Microbodies, Prostaglandins, Pyrimidines, Recombinant Fusion Proteins, Thiazoles, Transcription Factors, Prostaglandin D2, Signal Transduction, Transcriptional Activation, Adipocytes, Receptors, Cytoplasmic and Nuclear, Thiazolidinediones, Mice
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