Cited by 2,028Peroxisome Proliferator-Activated ReceptorsAdipose Tissue and MetabolismFatty Acid Research and Health

A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation

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Kliewer, Steven A., Lenhard, James M., Willson, Timothy M., Patel, Inder, Morris, David C., Lehmann, Jürgen M.·1995·Cell

Abstract

Prostaglandins (PGs) of the J2 series form in vivo and exert effects on a variety of biological processes. While most of PGs mediate their effects through G protein-coupled receptors, the mechanism of action for the J2 series of PGs remains unclear. Here, we report the PGJ2 and its derivatives are efficacious activators of peroxisome proliferator-activated receptors alpha and gamma (PPAR alpha and PPAR gamma, respectively), orphan nuclear receptors implicated in lipid homeostasis and adipocyte differentiation. The PGJ2 metabolite 15-deoxy-delta 12,14-PGJ2 binds directly to PPAR gamma and promotes efficient differentiation of C3H10T1/2 fibroblasts to adipocytes. These data provide strong evidence that a fatty acid metabolite can function as an adipogenic agent through direct interactions with PPAR gamma and furthermore, suggest a novel mechanism of action for PGs of the J2 series.

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Crossref · 10.1016/0092-8674(95)90194-9

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2 of 2 references verified0 citation errors · 0 not checkable

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  • P. acnes and its soluble factors may participate in the augmentation of sebaceous lipogenesis by increasing the production of 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2), an endogenous activator of PPARγ.

    “Interestingly, P. acnes and its soluble factors may also participate in the augmentation of sebaceous lipogenesis by increasing the production of the 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2), an endogenous activator of PPARγ.74”

    From Sebaceous-immunobiology is orchestrated by sebum lipids (2017) · cites this paper as [74]

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Authors
Kliewer, S. A., Lenhard, J. M., Willson, T. M., Patel, I., Morris, D. C., & Lehmann, J. M.
Venue
Cell
Publisher
Elsevier BV
Published
1995-12
Volume
83
Issue
5
Pages
813-819
ISSN
0092-8674 (ISSN-L)
OpenAlex
W2050717908
Cited by
2,028
References
2
Citations by year
2026: 8 · 2025: 15 · 2024: 15 · 2023: 16 · 2022: 23 · 2021: 26 · 2020: 20 · 2019: 31 · 2018: 38 · 2017: 19 · 2016: 35 · 2015: 34 · 2014: 38 · 2013: 50 · 2012: 66
FWCI
34.67
Type
journal article
Language
en
Open access
Locations
  • Cell (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Keywords
prostaglandin J2, 15-deoxy-Δ12,14-prostaglandin J2, PPARγ, PPARα, adipogenesis, nuclear receptor activation, C3H10T1/2 fibroblasts, fatty acid metabolites, mechanism of action, lipid homeostasis
MeSH terms
Rosiglitazone, Animals, Binding, Competitive, Cell Differentiation, Cells, Cultured, Fibroblasts, Hypoglycemic Agents, Ligands, Microbodies, Prostaglandins, Pyrimidines, Recombinant Fusion Proteins, Thiazoles, Transcription Factors, Prostaglandin D2, Signal Transduction, Transcriptional Activation, Adipocytes, Receptors, Cytoplasmic and Nuclear, Thiazolidinediones, Mice

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