The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The sequence of a large L1Md element reveals a tandemly repeated 5' end and several features found in retrotransposons.
Open accessAbstract
The complete nucleotide sequence of a 6,851-base pair (bp) member of the L1Md repetitive family from a selected random isolate of the BALB/c mouse genome is reported here. Five kilobases of the element contains two overlapping reading frames of 1,137 and 3,900 bp. The entire 3,900-bp frame and the 3' 600 bp of the 1,137-bp frame, when compared with a composite consensus primate L1 sequence, show a ratio of replacement to silent site differences characteristic of protein coding sequences. This more closely defines the protein coding capacity of this repetitive family, which was previously shown to possess a large open reading frame of undetermined extent. The relative organization of the 1,137- and 3,900-bp reading frames, which overlap by 14 bp, bears resemblance to protein-coding, mobile genetic elements. Homology can be found between the amino acid sequence of the 3,900-bp frame and selected domains of several reverse transcriptases. The 5' ends of the two L1Md elements described in this report have multiple copies, 4 2/3 copies and 1 2/3 copy, of a 208-bp direct tandem repeat. The sequence of this 208-bp element differs from the sequence of a previously defined 5' end for an L1Md element, indicating that there are at least two different 5' end motifs for L1Md.
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Citations
Cites
SINEs and LINEs: Highly repeated short and long interspersed sequences in mammalian genomes
Singer, M. F. (1982) · Cell · doi:10.1016/0092-8674(82)90194-5 · Cited by 431
Cited by
Origin and evolution of retroelements based upon their reverse transcriptase sequences
Xiong, Y., & Eickbush, T. H. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb07536.x · Cited by 1,374
Reverse Transcriptase Encoded by a Human Transposable Element
Mathias, S. L., Scott, A. F., Kazazian, H. H., Boeke, J. D., & Gabriel, A. (1991) · Science · doi:10.1126/science.1722352 · Cited by 773
Bulut-Karslioglu, A., De La Rosa-Velázquez, I. A., Ramirez, F., Barenboim, M., Onishi-Seebacher, M., Arand, J., Galán, C., Winter, G. E., Engist, B., Gerle, B., et al. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.05.029 · Cited by 368
Characterization of a synthetic human LINE-1 retrotransposon ORFeus-Hs
An, W., Dai, L., Niewiadomska, A. M., Yetil, A., O'Donnell, K. A., Han, J. S., & Boeke, J. D. (2011) · Mobile DNA · doi:10.1186/1759-8753-2-2 · Cited by 67
Li, P. W.-L. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkj490 · Cited by 53
Metadata
- Authors
- Loeb, D. D., Padgett, R. W., Hardies, S. C., Shehee, W. R., Comer, M. B., Edgell, M. H., & Hutchison, C. A.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1986-01
- Volume
- 6
- Issue
- 1
- Pages
- 168-182
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2163157311
- Cited by
- 327
- References
- 1
- FWCI
- 55.37
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: The sequence of a large L1Md element reveals a tandemly repeated 5' end and several features found in retrotransposons. https://app.cochat.ai/papers/10.1128/mcb.6.1.168
- The paper
- Loeb, D. D., Padgett, R. W., Hardies, S. C., Shehee, W. R., Comer, M. B., Edgell, M. H., & Hutchison, C. A. (1986). The sequence of a large L1Md element reveals a tandemly repeated 5' end and several features found in retrotransposons. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.6.1.168
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