The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Reverse Transcriptase Encoded by a Human Transposable Element
Abstract
L1 elements are highly repeated mammalian DNA sequences whose structure suggests dispersal by retrotransposition. A consensus L1 element encodes a protein with sequence similarity to known reverse transcriptases. The second open reading frame from the human L1 element L1.2A was expressed as a fusion protein targeted to Ty1 virus-like particles in Saccharomyces cerevisiae and shown to have reverse transcriptase activity. This activity was eliminated by a missense mutation in the highly conserved amino acid motif Y/F-X-D-D. Thus, L1 represents a potential source of the reverse transcriptase activity necessary for dispersion of the many classes of mammalian retroelements.
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Cites
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Isolation of an Active Human Transposable Element
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Self-citationA de novo Alu insertion results in neurofibromatosis type 1
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Self-citationLINE-1 elements in structural variation and disease
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Metadata
- Authors
- Mathias, S. L., Scott, A. F., Kazazian, H. H., Boeke, J. D., & Gabriel, A.
- Venue
- Science
- Published
- 1991-12-20
- Volume
- 254
- Issue
- 5039
- Pages
- 1808-1810
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1986319478
- Cited by
- 773
- References
- 34
- FWCI
- 28.77
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mathias, S. L., Scott, A. F., Kazazian, H. H., Boeke, J. D., & Gabriel, A. (1991). Reverse Transcriptase Encoded by a Human Transposable Element. Science. https://doi.org/10.1126/science.1722352
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
