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Classification and purification of proteins of heterogeneous nuclear ribonucleoprotein particles by RNA-binding specificities.
Open accessAbstract
Several proteins of heterogeneous nuclear ribonucleoprotein (hnRNP) particles display very high binding affinities for different ribonucleotide homopolymers. The specificity of some of these proteins at high salt concentrations and in the presence of heparin allows for their rapid one-step purification from HeLa nucleoplasm. We show that the hnRNP C proteins are poly(U)-binding proteins and compare their specificity to that of the previously described cytoplasmic poly(A)-binding protein. These findings provide a useful tool for the classification and purification of hnRNP proteins from various tissues and organisms and indicate that different hnRNP proteins have different RNA-binding specificities.
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Cited by
The protein product of the fragile X gene, FMR1, has characteristics of an RNA-binding protein.
Siomi, H., Siomi, M. C., Nussbaum, R. L., & Dreyfuss, G. (1993) · Cell · doi:10.1016/0092-8674(93)90420-u · Cited by 641
Self-citationFunctional diversity of the hnRNPs: past, present and perspectives
Han, S. P., Tang, Y. H., & Smith, R. (2010) · Biochemical Journal · doi:10.1042/bj20100396 · Cited by 527
Burd, C. G., & Dreyfuss, G. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06369.x · Cited by 488
Self-citationHuelga, S. C., Vu, A. Q., Arnold, J. D., Liang, T. Y., Liu, P. P., Yan, B. Y., Donohue, J. P., Shiue, L., Hoon, S., Brenner, S., et al. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.02.001 · Cited by 470
The poly(C)-binding proteins: A multiplicity of functions and a search for mechanisms
MAKEYEV, A. V., & LIEBHABER, S. A. (2002) · RNA · doi:10.1017/s1355838202024627 · Cited by 470
Metadata
- Authors
- Swanson, M. S., & Dreyfuss, G.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1988-05
- Volume
- 8
- Issue
- 5
- Pages
- 2237-2241
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2150093511
- Cited by
- 332
- References
- 0
- FWCI
- 5.08
- Type
- journal article
- Language
- en
- Open access
- green
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- Swanson, M. S., & Dreyfuss, G. (1988). Classification and purification of proteins of heterogeneous nuclear ribonucleoprotein particles by RNA-binding specificities. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.8.5.2237
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